Publication Details

Non-invasive bioluminescence imaging of myoblast-mediated hypoxia-inducible factor-1 alpha gene transfer.

Gheysens O, Chen IY, Rodriguez-Porcel M, Chan C, Rasooly J, Vaerenberg C, Paulmurugan R, Willmann JK, Deroose C, Wu J, Gambhir SS. Mol Imaging Biol. 2011; 13 (6): 1124-32

We tested a novel imaging strategy, in which both the survival of transplanted myoblasts and their therapeutic transgene expression, a recombinant hypoxia-inducible factor-1α (HIF-1α-VP2), can be monitored using firefly luciferase (fluc) and Renilla luciferase (hrl) bioluminescence reporter genes, respectively.

PubMedID: 21267661