Laura C. Lazzeroni, Ph.D.
Publication Details
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Aversive and reinforcing opioid effects: a pharmacogenomic twin study.
Anesthesiology. 2012; (1): 22-37
The clinical utility of opioids is limited by adverse drug effects including respiratory depression, sedation, nausea, and pruritus. In addition, abuse of prescription opioids is problematic. Gaining a better understanding of the genetic and environmental mechanisms contributing to an individual's susceptibility to adverse opioid effects is essential to identify patients at risk.
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