John Ioannidis
Publication Details
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What should the genome-wide significance threshold be? Empirical replication of borderline genetic associations.
Int J Epidemiol. 2012; (1): 273-86
Robust replication is a sine qua non for the rigorous documentation of proposed associations in the genome-wide association (GWA) setting. Currently, associations of common variants reaching P ≤ 5 × 10(-8) are considered replicated. However, there is some ambiguity about the most suitable threshold for claiming genome-wide significance.
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