Peter Parham
Publication Details
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Overlap in the repertoires of peptides bound in vivo by a group of related class I HLA-B allotypes.
Curr Biol. 1995; (2): 179-90
Polymorphism among class I molecules of the major histocompatibility complex (MHC) confers allotypic specificity on the peptides that these molecules bind and present to cytotoxic T lymphocytes. Evolution of new human HLA class I alleles usually involves gene recombination events that replace a segment of one allele with the homologous region of another. In this study, the impact of these evolutionary changes has been assessed by comparison of the peptide-binding specificities of six related HLA-B allotypes.
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