Alan M. Krensky, M.D.
Publication Details
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Induction of granulysin and perforin cytolytic mediator expression in 10-week-old infants vaccinated with BCG at birth.
Clin Dev Immunol. 2011: 438463
While vaccination at birth with Mycobacterium bovis Bacilli Calmette-Guérin (BCG) protects against severe childhood tuberculosis, there is no consensus as to which components of the BCG-induced immune response mediate this protection. However, granulysin and perforin, found in the granules of cytotoxic T lymphocytes and Natural Killer (NK) cells, can kill intracellular mycobacteria and are implicated in protection against Mycobacterium tuberculosis.
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