Anthony Oro MD/PhD
Publication Details
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Mammalian variations on a theme: a Smo and Sufu surprise.
Dev Cell. 2006; (2): 156-8
Hedgehog signaling plays a critical role during development and tumorigenesis. While much mechanistic insight has come from pathway investigations in the fruit fly, recent studies suggest a distinct mammalian strategy for signaling from Smoothened to Gli through the novel protein Suppressor of Fused that may have therapeutic implications.
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