Amato J. Giaccia
Publication Details
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Angiogenesis is required for successful bone induction during distraction osteogenesis.
J Bone Miner Res. 2005; (7): 1114-24
The role of angiogenesis during mechanically induced bone formation is incompletely understood. The relationship between the mechanical environment, angiogenesis, and bone formation was determined in a rat distraction osteogenesis model. Disruption of either the mechanical environment or endothelial cell proliferation blocked angiogenesis and bone formation. This study further defines the role of the mechanical environment and angiogenesis during distraction osteogenesis.
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