Philip Beachy
Publications
- Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell. 2013; (1): 23-34
- Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. Proc Natl Acad Sci U S A. 2011; (11): 4453-8
- Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder. Nature. 2011; (7341): 110-4
- Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proc Natl Acad Sci U S A. 2010; (30): 13432-7
- Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Proc Natl Acad Sci U S A. 2010; (13): 5869-74
- Genetic and biochemical definition of the Hedgehog receptor. Genes Dev. 2010; (1): 57-71
- Interactions between Hedgehog proteins and their binding partners come into view. Genes Dev. 2010; (18): 2001-12
- Itraconazole, a commonly used antifungal that inhibits Hedgehog pathway activity and cancer growth. Cancer Cell. 2010; (4): 388-99
- Patterning axon targeting of olfactory receptor neurons by coupled hedgehog signaling at two distinct steps. Cell. 2010; (6): 954-66
- Gli2 trafficking links Hedgehog-dependent activation of Smoothened in the primary cilium to transcriptional activation in the nucleus. Proc Natl Acad Sci U S A. 2009; (51): 21666-71
- Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice. Gastroenterology. 2012; (5): 1195-1205.e6
- Scube/You activity mediates release of dually lipid-modified Hedgehog signal in soluble form. Genes Dev. 2012; (12): 1312-25
- Hedgehogs, flies, Wnts and MYCs: the time has come for many things in medulloblastoma. J Clin Oncol. 2011; (11): 1395-8
- Structure of the protein core of the glypican Dally-like and localization of a region important for hedgehog signaling. Proc Natl Acad Sci U S A. 2011; (32): 13112-7
- Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia. Nature. 2009; (7239): 776-9
- Truncating loss-of-function mutations of DISP1 contribute to holoprosencephaly-like microform features in humans. Hum Genet. 2009; (4): 393-400
- Targeted inhibition of hedgehog signaling by cyclopamine prodrugs for advanced prostate cancer. Bioorg Med Chem. 2008; (6): 2764-8
- The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla. Nature. 2008; (7215): 979-83
- Disruption of the basal body compromises proteasomal function and perturbs intracellular Wnt response. Nat Genet. 2007; (11): 1350-60
- Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc. Natl. Acad. Sci. U.S.A.. 2007: 4048-4053
- Hedgehog signaling maintains a tumor stem cell compartment in multiple myeloma. Proc Natl Acad Sci U S A. 2007; (10): 4048-53
- Misexpression of Sox9 in mouse limb bud mesenchyme induces polydactyly and rescues hypodactyly mice. Matrix Biol. 2007; (4): 224-33
- Oxysterols are novel activators of the hedgehog signaling pathway in pluripotent mesenchymal cells. J Biol Chem. 2007; (12): 8959-68
- A genomewide screen for components of the RNAi pathway in Drosophila cultured cells. Proc Natl Acad Sci U S A. 2006; (32): 11880-5
- Defective cerebellar response to mitogenic Hedgehog signaling in Down [corrected] syndrome mice. Proc Natl Acad Sci U S A. 2006; (5): 1452-6
- Defective cerebellar response to mitogenic Hedgehog signaling in Down syndrome mice. Proc. Natl. Acad. Sci. U.S.A.. 2006: 1452-1456
- Minimizing the risk of reporting false positives in large-scale RNAi screens. Nat Methods. 2006; (10): 777-9
- Prevalence of off-target effects in Drosophila RNA interference screens. Nature. 2006; (7109): 359-63
- Structure of a heparin-dependent complex of Hedgehog and Ihog. Proc Natl Acad Sci U S A. 2006; (46): 17208-13
- Structure of a heparin-dependent complex of Hedgehog and Ihog. Proc. Natl. Acad. Sci. U.S.A.. 2006: 17208-17213
- The ihog cell-surface proteins bind Hedgehog and mediate pathway activation Cell. 2006: 343-357
- Transcriptional activation by extradenticle in the Drosophila visceral mesoderm. Dev Biol. 2006; (2): 482-94
- Molecular mechanisms of Sonic hedgehog mutant effects in holoprosencephaly. Proc Natl Acad Sci U S A. 2005; (47): 17026-31
- Activity-dependent internalization of smoothened mediated by beta-arrestin 2 and GRK2. Science. 2004; (5705): 2257-60
- Extensive phosphorylation of Smoothened in Hedgehog pathway activation. Proc Natl Acad Sci U S A. 2004; (52): 17900-7
- Hedgehog signalling in prostate regeneration, neoplasia and metastasis. Nature. 2004; (7009): 707-12
- Mending and malignancy. Nature. 2004; (7007): 402
- Novel lipid modifications of secreted protein signals. Annu Rev Biochem. 2004: 891-923
- Roles for Hedgehog signaling in androgen production and prostate ductal morphogenesis. Dev Biol. 2004; (2): 387-98
- The Hedgehog response network: sensors, switches, and routers. Science. 2004; (5678): 1755-9
- The SmoA1 mouse model reveals that notch signaling is critical for the growth and survival of sonic hedgehog-induced medulloblastomas. Cancer Res. 2004; (21): 7794-800
- Tissue repair and stem cell renewal in carcinogenesis. Nature. 2004; (7015): 324-31
- A defective response to Hedgehog signaling in disorders of cholesterol biosynthesis. Nat Genet. 2003; (4): 508-13
- Hedgehog signal transduction via Smoothened association with a cytoplasmic complex scaffolded by the atypical kinesin, Costal-2. Mol Cell. 2003; (5): 1261-74
- Hedgehog signalling within airway epithelial progenitors and in small-cell lung cancer. Nature. 2003; (6929): 313-7
- Identification of Hedgehog pathway components by RNAi in Drosophila cultured cells. Science. 2003; (5615): 2039-45
- Widespread requirement for Hedgehog ligand stimulation in growth of digestive tract tumours. Nature. 2003; (6960): 846-51
- Differential requirements for shh in mammary tissue and hair follicle morphogenesis. Dev Biol. 2002; (1): 131-9
- Hedgehog-mediated patterning of the mammalian embryo requires transporter-like function of dispatched. Cell. 2002; (1): 63-75
- Inhibition of Hedgehog signaling by direct binding of cyclopamine to Smoothened. Genes Dev. 2002; (21): 2743-8
- Medulloblastoma growth inhibition by hedgehog pathway blockade. Science. 2002; (5586): 1559-61
- Patched acts catalytically to suppress the activity of Smoothened. Nature. 2002; (6900): 892-7
- Small molecule modulation of Smoothened activity. Proc Natl Acad Sci U S A. 2002; (22): 14071-6
- Expression and regulation of chicken fibroblast growth factor homologous factor (FHF)-4 during craniofacial morphogenesis. Dev Dyn. 2001; (3): 238-45
- Manifestation of the limb prepattern: limb development in the absence of sonic hedgehog function. Dev Biol. 2001; (2): 421-35
- Skinny hedgehog, an acyltransferase required for palmitoylation and activity of the hedgehog signal. Science. 2001; (5537): 2080-4
- The Hedgehog and Wnt signalling pathways in cancer. Nature. 2001; (6835): 349-54
- Cholesterol modification of proteins. Biochim Biophys Acta. 2000; (1-3): 188-202
- Effects of oncogenic mutations in Smoothened and Patched can be reversed by cyclopamine. Nature. 2000; (6799): 1005-9
- Genetics of ventral forebrain development and holoprosencephaly. Curr Opin Genet Dev. 2000; (3): 262-9
- Hedgehog-regulated processing of Gli3 produces an anterior/posterior repressor gradient in the developing vertebrate limb. Cell. 2000; (4): 423-34
- Essential role for Sonic hedgehog during hair follicle morphogenesis. Dev Biol. 1999; (1): 1-9
- Nuclear trafficking of Cubitus interruptus in the transcriptional regulation of Hedgehog target gene expression. Cell. 1999; (3): 305-16
- Sonic hedgehog protein signals not as a hydrolytic enzyme but as an apparent ligand for patched. Proc Natl Acad Sci U S A. 1999; (20): 10992-9
- Patterning of the embryonic forebrain. Curr Opin Neurobiol. 1998; (1): 18-26
- Teratogen-mediated inhibition of target tissue response to Shh signaling. Science. 1998; (5369): 1603-7
- Crystal structure of a Hedgehog autoprocessing domain: homology between Hedgehog and self-splicing proteins. Cell. 1997; (1): 85-97
- Mediation of Sonic hedgehog-induced expression of COUP-TFII by a protein phosphatase. Science. 1997; (5345): 1947-50
- Multiple roles of cholesterol in hedgehog protein biogenesis and signaling. Cold Spring Harb Symp Quant Biol. 1997: 191-204
- Cholesterol modification of hedgehog signaling proteins in animal development. Science. 1996; (5285): 255-9
- Cyclopia and defective axial patterning in mice lacking Sonic hedgehog gene function. Nature. 1996; (6599): 407-13
- Hedgehog patterning activity: role of a lipophilic modification mediated by the carboxy-terminal autoprocessing domain. Cell. 1996; (1): 21-34
- Overexpression of a Rrp1 transgene reduces the somatic mutation and recombination frequency induced by oxidative DNA damage in Drosophila melanogaster. Proc Natl Acad Sci U S A. 1996; (4): 1607-12
- pH-dependent enhancement of DNA binding by the ultrabithorax homeodomain. Biochemistry. 1996; (30): 9832-9
- A potential catalytic site revealed by the 1.7-A crystal structure of the amino-terminal signalling domain of Sonic hedgehog. Nature. 1995; (6553): 212-6
- Control of Drosophila tracheal branching by the novel homeodomain gene unplugged, a regulatory target for genes of the bithorax complex. Development. 1995; (11): 3901-12
- Distinct expression and shared activities of members of the hedgehog gene family of Xenopus laevis. Development. 1995; (8): 2337-47
- Floor plate and motor neuron induction by different concentrations of the amino-terminal cleavage product of sonic hedgehog autoproteolysis. Cell. 1995; (3): 445-55
- Induction of midbrain dopaminergic neurons by Sonic hedgehog. Neuron. 1995; (1): 35-44
- Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage. Curr Biol. 1995; (7): 791-6
- Long-range sclerotome induction by sonic hedgehog: direct role of the amino-terminal cleavage product and modulation by the cyclic AMP signaling pathway. Cell. 1995; (3): 457-65
- Patterning activities of vertebrate hedgehog proteins in the developing eye and brain. Curr Biol. 1995; (8): 944-55
- Patterning of the neural ectoderm of Xenopus laevis by the amino-terminal product of hedgehog autoproteolytic cleavage. Development. 1995; (8): 2349-60
- The product of hedgehog autoproteolytic cleavage active in local and long-range signalling. Nature. 1995; (6520): 363-6
- Ultrabithorax protein is necessary but not sufficient for full activation of decapentaplegic expression in the visceral mesoderm. EMBO J. 1995; (3): 520-35
- Autoproteolysis in hedgehog protein biogenesis. Science. 1994; (5190): 1528-37
- Expression of a novel Toll-like gene spans the parasegment boundary and contributes to hedgehog function in the adult eye of Drosophila. Mech Dev. 1994; (3): 225-39
- Products, genetic linkage and limb patterning activity of a murine hedgehog gene. Development. 1994; (11): 3339-53
- The degree of variation in DNA sequence recognition among four Drosophila homeotic proteins. EMBO J. 1994; (15): 3551-60
- The novel homeodomain gene buttonless specifies differentiation and axonal guidance functions of Drosophila dorsal median cells. Development. 1994; (12): 3581-93
- Cooperative binding of an Ultrabithorax homeodomain protein to nearby and distant DNA sites. Mol Cell Biol. 1993; (11): 6941-56
- The segment polarity gene hedgehog is required for progression of the morphogenetic furrow in the developing Drosophila eye. Cell. 1993; (5): 927-38
- Differential DNA sequence recognition is a determinant of specificity in homeotic gene action. EMBO J. 1992; (11): 4059-72
- Secretion and localized transcription suggest a role in positional signaling for products of the segmentation gene hedgehog. Cell. 1992; (1): 33-50
- Optimal DNA sequence recognition by the Ultrabithorax homeodomain of Drosophila. EMBO J. 1991; (5): 1179-86
- A molecular view of the Ultrabithorax homeotic gene of Drosophila. Trends Genet. 1990; (2): 46-51
- Structure and expression of a family of Ultrabithorax mRNAs generated by alternative splicing and polyadenylation in Drosophila. Genes Dev. 1989; (2): 243-58
- An Ultrabithorax protein binds sequences near its own and the Antennapedia P1 promoters. Cell. 1988; (6): 1069-81
- Segmental distribution of bithorax complex proteins during Drosophila development. Nature. 1985 Feb 14-20; (6003): 545-51
- Regulation and products of the Ubx domain of the bithorax complex. Cold Spring Harb Symp Quant Biol. 1985: 181-94
- Molecular Genetics of the Bithorax Complex in Drosophila melanogaster. Science. 1983; (4605): 23-9
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