Frank M. Longo, M.D., Ph.D.
Publications
- A small molecule p75(NTR) ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model. Neurobiol Aging. 2013; (8): 2052-63
- Oral administration of a small molecule targeted to block proNGF binding to p75 promotes myelin sparing and functional recovery after spinal cord injury. J Neurosci. 2013; (2): 397-410
- A TrkB small molecule partial agonist rescues TrkB phosphorylation deficits and improves respiratory function in a mouse model of Rett syndrome. J Neurosci. 2012; (5): 1803-10
- Delayed administration of a small molecule tropomyosin-related kinase B ligand promotes recovery after hypoxic-ischemic stroke. Stroke. 2012; (7): 1918-24
- Suppression of immunodeficiency virus-associated neural damage by the p75 neurotrophin receptor ligand, LM11A-31, in an in vitro feline model. J Neuroimmune Pharmacol. 2012; (2): 388-400
- Thy1-hAPP(Lond/Swe+) mouse model of Alzheimer's disease displays broad behavioral deficits in sensorimotor, cognitive and social function. Brain Behav. 2012; (2): 142-54
- Leukocyte common antigen-related phosphatase is a functional receptor for chondroitin sulfate proteoglycan axon growth inhibitors. J Neurosci. 2011; (40): 14051-66
- Small molecule BDNF mimetics activate TrkB signaling and prevent neuronal degeneration in rodents. J Clin Invest. 2010; (5): 1774-85
- The p75 neurotrophin receptor is expressed by adult mouse dentate progenitor cells and regulates neuronal and non-neuronal cell genesis. BMC Neurosci. 2010: 136
- Signaling through Rho GTPase pathway as viable drug target. Curr Med Chem. 2009; (11): 1355-65
- The p75 neurotrophin receptor promotes amyloid-beta(1-42)-induced neuritic dystrophy in vitro and in vivo. J Neurosci. 2009; (34): 10627-37
- A common motif targets huntingtin and the androgen receptor to the proteasome. J Biol Chem. 2008; (35): 23950-5
- Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants. Neurotoxicology. 2008; (4): 605-12
- Small molecule modulation of p75 neurotrophin receptor functions. CNS Neurol Disord Drug Targets. 2008; (1): 63-70
- Small molecule, non-peptide p75 ligands inhibit Abeta-induced neurodegeneration and synaptic impairment. PLoS One. 2008; (11): e3604
- E-cadherin promotes retinal ganglion cell neurite outgrowth in a protein tyrosine phosphatase-mu-dependent manner. Mol Cell Neurosci. 2007; (3): 481-92
- Small molecule neurotrophin receptor ligands: novel strategies for targeting Alzheimer's disease mechanisms. Curr Alzheimer Res. 2007; (5): 503-6
- Downregulation of the LAR protein tyrosine phosphatase receptor is associated with increased dentate gyrus neurogenesis and an increased number of granule cell layer neurons. Mol Cell Neurosci. 2006; (4): 723-38
- LAR protein tyrosine phosphatase receptor associates with TrkB and modulates neurotrophic signaling pathways. J Neurobiol. 2006; (13): 1420-36
- Modulation of p75-dependent motor neuron death by a small non-peptidyl mimetic of the neurotrophin loop 1 domain. Eur J Neurosci. 2006; (6): 1575-80
- Protein-tyrosine phosphatase (PTP) wedge domain peptides: a novel approach for inhibition of PTP function and augmentation of protein-tyrosine kinase function. J Biol Chem. 2006; (24): 16482-92
- Small molecule approaches for promoting neurogenesis. Curr Alzheimer Res. 2006; (1): 5-10
- Small, nonpeptide p75NTR ligands induce survival signaling and inhibit proNGF-induced death. J Neurosci. 2006; (20): 5288-300
- Identification of an ectodomain within the LAR protein tyrosine phosphatase receptor that binds homophilically and activates signalling pathways promoting neurite outgrowth. Eur J Neurosci. 2005; (9): 2159-70
- Neurotrophin Small Molecule Mimetics: Candidate Therapeutic Agents for Neurological Disorders Curr Med Chem - CNS Agents. 2005: 29-41
- Neurotrophin receptor-based strategies for Alzheimer's disease. Curr Alzheimer Res. 2005; (2): 167-9
- Neuroprotective strategies in Alzheimer's disease. NeuroRx. 2004; (1): 117-27
- Neurotrophin-based strategies for neuroprotection. J Alzheimers Dis. 2004; (6 Suppl): S13-7
- A candidate chimeric mammalian mRNA transcript is derived from distinct chromosomes and is associated with nonconsensus splice junction motifs. DNA Cell Biol. 2003; (5): 303-15
- Alzheimer's therapeutics: neurotrophin domain small molecule mimetics. J Mol Neurosci. 2003; (3): 323-6
- Leukocyte antigen-related protein tyrosine phosphatase receptor: a small ectodomain isoform functions as a homophilic ligand and promotes neurite outgrowth. J Neurosci. 2003; (8): 3353-63
- Alzheimer's therapeutics: neurotrophin small molecule mimetics. J Mol Neurosci. 2002 Aug-Oct; (1-2): 107-11
- Modulation of Alzheimer-like synaptic and cholinergic deficits in transgenic mice by human apolipoprotein E depends on isoform, aging, and overexpression of amyloid beta peptides but not on plaque formation. J Neurosci. 2002; (24): 10539-48
- ProNGF induces p75-mediated death of oligodendrocytes following spinal cord injury. Neuron. 2002; (3): 375-86
- Psychological impact of news of genetic risk for Huntington disease. Am J Med Genet. 2001; (3): 188-92
- The leukocyte common antigen-related protein tyrosine phosphatase receptor regulates regenerative neurite outgrowth in vivo. J Neurosci. 2001; (14): 5130-8
- Downregulation of LAR tyrosine phosphatase prevents apoptosis and augments NGF-induced neurite outgrowth. J Neurobiol. 2000; (4): 477-86
- Leukocyte common-antigen-related tyrosine phosphatase receptor: altered expression of mRNA and protein in the New England Deaconess Hospital rat line exhibiting spontaneous pheochromocytoma. Carcinogenesis. 2000; (2): 125-31
- Nerve growth factor (NGF) loop 4 dimeric mimetics activate ERK and AKT and promote NGF-like neurotrophic effects. J Biol Chem. 2000; (38): 29868-74
- Neurotrophin small-molecule mimetics. Prog Brain Res. 2000: 333-47
- Stress induces zinc finger immediate early genes in the rat adrenal gland. Brain Res. 2000; (2): 203-8
- Electromagnetic fields influence NGF activity and levels following sciatic nerve transection. J Neurosci Res. 1999; (2): 230-7
- Gene expression along the cerebral-spinal axis after regional gene delivery. Hum Gene Ther. 1999; (16): 2689-700
- Leukocyte common antigen-related tyrosine phosphatase receptor: increased expression and neuronal-type splicing in breast cancer cells and tissue. Mol Carcinog. 1999; (2): 139-49
- LAR Tyrosine Phosphatase Receptor: A Developmental Isoform Is Present in Neurites and Growth Cones and Its Expression Is Regional- and Cell-Specific. Mol Cell Neurosci. 1998; (5/6): 271-86
- LAR tyrosine phosphatase receptor: a developmental isoform is present in neurites and growth cones and its expression is regional- and cell-specific. Mol Cell Neurosci. 1998; (5-6): 271-86
- LAR tyrosine phosphatase receptor: proximal membrane alternative splicing is coordinated with regional expression and intraneuronal localization. Brain Res Mol Brain Res. 1998; (1): 1-12
- Absence of p75NTR causes increased basal forebrain cholinergic neuron size, choline acetyltransferase activity, and target innervation. J Neurosci. 1997; (20): 7594-605
- Aldose reductase inhibition increases CNTF-like bioactivity and protein in sciatic nerves from galactose-fed and normal rats. Diabetes. 1997; (4): 647-52
- Deficient LAR expression decreases basal forebrain cholinergic neuronal size and hippocampal cholinergic innervation. J Neurosci Res. 1997; (3): 348-60
- Synthetic NGF peptide derivatives prevent neuronal death via a p75 receptor-dependent mechanism. J Neurosci Res. 1997; (1): 1-17
- Minimized hormones grow in stature. Nat Biotechnol. 1996; (9): 1092
- Cloning of rat grp75, an hsp70-family member, and its expression in normal and ischemic brain. J Neurosci Res. 1995; (6): 807-19
- LAR tyrosine phosphatase receptor: alternative splicing is preferential to the nervous system, coordinated with cell growth and generates novel isoforms containing extensive CAG repeats. J Cell Biol. 1995; (3): 415-31
- Will ciliary neurotrophic factor slow progression of motor neuron disease? Ann Neurol. 1994; (2): 125-7
- Heat shock proteins used to show that haloperidol prevents neuronal injury produced by ketamine, MK801, and phencyclidine. Ann N Y Acad Sci. 1993: 288-90
- Induction of glucose regulated protein (grp78) and inducible heat shock protein (hsp70) mRNAs in rat brain after kainic acid seizures and focal ischemia. Neurochem Int. 1993; (6): 575-82
- Leukocyte common antigen-related receptor-linked tyrosine phosphatase. Regulation of mRNA expression. J Biol Chem. 1993; (35): 26503-11
- Prolonged increases in neurotrophic activity associated with kainate-induced hippocampal synaptic reorganization. Neuroscience. 1993; (3): 597-604
- cDNA cloning and expression of stress-inducible rat hsp70 in normal and injured rat brain. J Neurosci Res. 1993; (3): 325-35
- Haloperidol prevents induction of the hsp70 heat shock gene in neurons injured by phencyclidine (PCP), MK801, and ketamine. J Neurosci Res. 1992; (4): 605-16
- Direct sequencing of PCR products using the Maxam-Gilbert method. Genet Anal Tech Appl. 1990; (5): 142-3
- Nerve growth factor induces gene expression of the prion protein and beta-amyloid protein precursor in the developing hamster central nervous system. Prog Brain Res. 1990: 227-38
- The in vitro biological effect of nerve growth factor is inhibited by synthetic peptides. Cell Regul. 1990; (2): 189-95
- Trophic actions of recombinant human nerve growth factor on cultured rat embryonic CNS cells. Exp Neurol. 1990; (3): 274-83
- Developmental regulation of nerve growth factor and its receptor in the rat caudate-putamen. Neuron. 1989; (5): 655-64
- Nerve regeneration through artificial tubular implants. Prog Neurobiol. 1989; (2): 87-134
- White matter disease in AIDS: findings at MR imaging. Radiology. 1988; (2): 445-8
- Abnormal nerve regeneration in galactose neuropathy. J Neuropathol Exp Neurol. 1986; (2): 151-60
- Delayed nerve regeneration in streptozotocin diabetic rats. Muscle Nerve. 1986; (5): 385-93
- Neurite-promoting factors and extracellular matrix components accumulating in vivo within nerve regeneration chambers. Brain Res. 1984; (1): 105-17
- Neuronotrophic activities in cerebrospinal fluid of head trauma patients. Exp Neurol. 1984; (1): 207-18
- Endogenous and exogenous factors support neuronal survival and choline acetyltransferase activity in embryonic spinal cord cultures. Brain Res. 1983; (1): 57-66
- Laminin promotes neuritic regeneration from cultured peripheral and central neurons. J Cell Biol. 1983; (6): 1882-90
- Neuronotrophic activities accumulate in vivo within silicone nerve regeneration chambers. Brain Res. 1983; (1): 109-16
- Neuronotrophic activity in brain wounds of the developing rat. Correlation with implant survival in the wound cavity. Brain Res. 1983; (1): 47-56
- Spatial-temporal progress of peripheral nerve regeneration within a silicone chamber: parameters for a bioassay. J Comp Neurol. 1983; (4): 460-70
- Temporal changes of neuronotrophic activities accumulating in vivo within nerve regeneration chambers. Exp Neurol. 1983; (3): 756-69
- Brain injury causes a time-dependent increase in neuronotrophic activity at the lesion site. Science. 1982; (4562): 860-1
- Comparative features of spinal neuronotrophic factors in fluids collected in vitro and in vivo. J Neurosci Res. 1982; (2-3): 241-50
- Growth factors and motor neurons. Adv Neurol. 1982: 453-72
- In vivo regeneration of cut nerves encased in silicone tubes: growth across a six-millimeter gap. J Neuropathol Exp Neurol. 1982; (4): 412-22
- Nerve regeneration across an extended gap: a neurobiological view of nerve repair and the possible involvement of neuronotrophic factors. J Hand Surg Am. 1982; (6): 580-7
- Nerve regeneration in silicone chambers: influence of gap length and of distal stump components. Exp Neurol. 1982; (2): 361-75
- Nerve regeneration model and trophic factors in vivo. Brain Res. 1982; (1): 157-61
- Spinal cord neuronotrophic factors (SCNTFs): I. Bioassay of schwannoma and other conditioned media. Brain Res. 1982; (2): 277-94
- Relation of somal lipid synthesis to the fast axonal transport of protein and lipid. Brain Res. 1980; (2): 471-85
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