Michael F. Clarke, M.D.
Publications
- MicroRNA-30c inhibits human breast tumour chemotherapy resistance by regulating TWF1 and IL-11. Nat Commun. 2013: 1393
- Identification of a cKit(+) colonic crypt base secretory cell that supports Lgr5(+) stem cells in mice. Gastroenterology. 2012; (5): 1195-1205.e6
- Innate immune response to homologous rotavirus infection in the small intestinal villous epithelium at single-cell resolution. Proc Natl Acad Sci U S A. 2012; (50): 20667-72
- Remodeling of endogenous mammary epithelium by breast cancer stem cells. Stem Cells. 2012; (10): 2114-27
- Stimulation of natural killer cells with a CD137-specific antibody enhances trastuzumab efficacy in xenotransplant models of breast cancer. J Clin Invest. 2012; (3): 1066-75
- The CD47-signal regulatory protein alpha (SIRPa) interaction is a therapeutic target for human solid tumors. Proc Natl Acad Sci U S A. 2012; (17): 6662-7
- Removal of lactate dehydrogenase-elevating virus from human-in-mouse breast tumor xenografts by cell-sorting. J Virol Methods. 2011; (2): 266-70
- Single-cell dissection of transcriptional heterogeneity in human colon tumors. Nat Biotechnol. 2011; (12): 1120-7
- Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models. Proc Natl Acad Sci U S A. 2010; (42): 18115-20
- The Myc connection: ES cells and cancer. Cell. 2010; (2): 184-6
- Association of reactive oxygen species levels and radioresistance in cancer stem cells. Nature. 2009; (7239): 780-3
- Automated microfluidic chromatin immunoprecipitation from 2,000 cells. Lab Chip. 2009; (10): 1365-70
- DLL4 blockade inhibits tumor growth and reduces tumor-initiating cell frequency. Cell Stem Cell. 2009; (2): 168-77
- Downregulation of miRNA-200c links breast cancer stem cells with normal stem cells. Cell. 2009; (3): 592-603
- Dysregulated gene expression networks in human acute myelogenous leukemia stem cells. Proc Natl Acad Sci U S A. 2009; (9): 3396-401
- Radiation Therapy Oncology Group translational research program stem cell symposium: incorporating stem cell hypotheses into clinical trials. Int J Radiat Oncol Biol Phys. 2009; (5): 1580-91
- Therapeutic implications of the cancer stem cell hypothesis. Semin Radiat Oncol. 2009; (2): 78-86
- Colorectal cancer stem cells are enriched in xenogeneic tumors following chemotherapy. PLoS One. 2008; (6): e2428
- Isolation and molecular characterization of cancer stem cells in MMTV-Wnt-1 murine breast tumors. Stem Cells. 2008; (2): 364-71
- Long-term haematopoietic reconstitution by Trp53-/-p16Ink4a-/-p19Arf-/- multipotent progenitors. Nature. 2008; (7192): 228-32
- Recent advances in cancer stem cells. Curr Opin Genet Dev. 2008; (1): 48-53
- What can we learn about breast cancer from stem cells? Adv Exp Med Biol. 2008: 17-22
- Bmi-1-green fluorescent protein-knock-in mice reveal the dynamic regulation of bmi-1 expression in normal and leukemic hematopoietic cells. Stem Cells. 2007; (7): 1635-44
- Cancer stem cells and tumor metastasis: first steps into uncharted territory. Cell Stem Cell. 2007; (3): 241-2
- Cancer stem cells: models and concepts. Annu Rev Med. 2007: 267-84
- Chromosome 5q deletion and epigenetic suppression of the gene encoding alpha-catenin (CTNNA1) in myeloid cell transformation. Nat Med. 2007; (1): 78-83
- Identification of a subpopulation of cells with cancer stem cell properties in head and neck squamous cell carcinoma. Proc Natl Acad Sci U S A. 2007; (3): 973-8
- Identification of pancreatic cancer stem cells. Cancer Res. 2007; (3): 1030-7
- Phenotypic characterization of human colorectal cancer stem cells. Proc Natl Acad Sci U S A. 2007; (24): 10158-63
- The biology of cancer stem cells. Annu Rev Cell Dev Biol. 2007: 675-99
- The prognostic role of a gene signature from tumorigenic breast-cancer cells. N Engl J Med. 2007; (3): 217-26
- Cancer stem cells and radiotherapy: new insights into tumor radioresistance. J Natl Cancer Inst. 2006; (24): 1755-7
- Cancer stem cells--perspectives on current status and future directions: AACR Workshop on cancer stem cells. Cancer Res. 2006; (19): 9339-44
- Hematopoietic stem cell self-renewal. Curr Opin Genet Dev. 2006; (5): 496-501
- Oncogenes, self-renewal and cancer. Pathol Biol (Paris). 2006; (2): 109-11
- Stem cells and cancer: two faces of eve. Cell. 2006; (6): 1111-5
- Stem cells: the real culprits in cancer? Sci Am. 2006; (1): 52-9
- A self-renewal assay for cancer stem cells. Cancer Chemother Pharmacol. 2005: 64-8
- Epigenetic regulation of normal and cancer stem cells. Ann N Y Acad Sci. 2005: 90-3
- Self-renewal and solid-tumor stem cells. Biol Blood Marrow Transplant. 2005; (2 Suppl 2): 14-6
- Bmi1, stem cells, and senescence regulation. J Clin Invest. 2004; (2): 175-9
- Chronic myelogenous leukemia--identifying the hydra's heads. N Engl J Med. 2004; (7): 634-6
- Neurobiology: at the root of brain cancer. Nature. 2004; (7015): 281-2
- Self-renewal and solid tumor stem cells. Oncogene. 2004; (43): 7274-82
- Therapeutic implications of cancer stem cells. Curr Opin Genet Dev. 2004; (1): 43-7
- Applying the principles of stem-cell biology to cancer. Nat Rev Cancer. 2003; (12): 895-902
- Bmi-1 dependence distinguishes neural stem cell self-renewal from progenitor proliferation. Nature. 2003; (6961): 962-7
- Bmi-1 is required for maintenance of adult self-renewing haematopoietic stem cells. Nature. 2003; (6937): 302-5
- In vitro propagation and transcriptional profiling of human mammary stem/progenitor cells. Genes Dev. 2003; (10): 1253-70
- Prospective identification of tumorigenic breast cancer cells. Proc Natl Acad Sci U S A. 2003; (7): 3983-8
- Stem cells in normal breast development and breast cancer. Cell Prolif. 2003: 59-72
- A genetic determinant that specifically regulates the frequency of hematopoietic stem cells. J Immunol. 2002; (2): 635-42
- Differential gene expression profiling of adult murine hematopoietic stem cells. Blood. 2002; (2): 488-98
- New oncolytic adenoviruses with hypoxia- and estrogen receptor-regulated replication. Hum Gene Ther. 2002; (14): 1737-50
- SLUGging away at cell death. Cancer Cell. 2002; (4): 249-51
- Clinical protocol. Purging of autologous stem cell sources with bcl-x(s) adenovirus for women undergoing high-dose chemotherapy for stage IV breast carcinoma. Hum Gene Ther. 2001; (16): 2023-5
- Double dose-intensive chemotherapy with autologous stem cell support for relapsed and refractory testicular cancer: the University of Michigan experience and literature review. Bone Marrow Transplant. 2001; (9): 939-47
- Evaluation of a new dual-specificity promoter for selective induction of apoptosis in breast cancer cells. Cancer Gene Ther. 2001; (4): 298-307
- Molecular cloning and characterization of a novel regulator of G-protein signaling from mouse hematopoietic stem cells. J Biol Chem. 2001; (2): 915-23
- Regulation of p53 localization. Eur J Biochem. 2001; (10): 2779-83
- Stem cells, cancer, and cancer stem cells. Nature. 2001; (6859): 105-11
- A novel, conditionally replicative adenovirus for the treatment of breast cancer that allows controlled replication of E1a-deleted adenoviral vectors. Hum Gene Ther. 2000; (14): 2009-24
- A bipartite nuclear localization signal is required for p53 nuclear import regulated by a carboxyl-terminal domain. J Biol Chem. 1999; (46): 32699-703
- Germ cell tumor: differentiation of viable tumor, mature teratoma, and necrotic tissue with FDG PET and kinetic modeling. Radiology. 1999; (1): 249-56
- The nuclear import of p53 is determined by the presence of a basic domain and its relative position to the nuclear localization signal. Oncogene. 1999; (12): 2163-6
- A method of limited replication for the efficient in vivo delivery of adenovirus to cancer cells. Hum Gene Ther. 1998; (8): 1209-16
- Cooperation of a single lysine mutation and a C-terminal domain in the cytoplasmic sequestration of the p53 protein. J Biol Chem. 1998; (31): 19817-21
- Role of p53 in the regulation of irradiation-induced apoptosis in neuroblastoma cells. Mol Genet Metab. 1998; (2): 155-64
- Targeting cancer cell death with a bcl-XS adenovirus. Springer Semin Immunopathol. 1998; (3): 279-88
- Prevention of fluorodeoxyuridine-induced cytotoxicity and DNA damage in HT29 colon carcinoma cells by conditional expression of wild-type p53 phenotype. Mol Pharmacol. 1997; (4): 600-5
- Bcl-xS enhances adenoviral vector-induced apoptosis in neuroblastoma cells. Cancer Res. 1996; (24): 5734-40
- Retroviral infection is limited by Brownian motion. Hum Gene Ther. 1996; (13): 1527-34
- bcl-xs gene therapy induces apoptosis of human mammary tumors in nude mice. Cancer Res. 1996; (9): 1965-9
- A recombinant bcl-x s adenovirus selectively induces apoptosis in cancer cells but not in normal bone marrow cells. Proc Natl Acad Sci U S A. 1995; (24): 11024-8
- Bcl-2 protects murine erythroleukemia cells from p53-dependent and -independent radiation-induced cell death. Carcinogenesis. 1995; (8): 1761-7
- Bcl-XL protects cancer cells from p53-mediated apoptosis. Oncogene. 1995; (7): 1389-94
- In vitro expansion of hematopoietic cells for clinical application. Cancer Treat Res. 1995: 215-23
- Overexpression of Bcl-XS sensitizes MCF-7 cells to chemotherapy-induced apoptosis. Cancer Res. 1995; (12): 2507-10
- Retroviral-mediated gene transfer in human bone marrow cells growth in continuous perfusion culture vessels. Blood. 1995; (10): 3754-62
- Alteration of p53 conformation and induction of apoptosis in a murine erythroleukemia cell line by dimethylsulfoxide. Leuk Res. 1994; (8): 617-21
- The Bcl-2 family of proteins: regulators of cell death and survival. Trends Cell Biol. 1994; (11): 399-403
- c-myc and bcl-2 modulate p53 function by altering p53 subcellular trafficking during the cell cycle. Proc Natl Acad Sci U S A. 1994; (13): 5878-82
- Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells. Mol Cell Biol. 1993; (1): 711-9
- Can Dexter cultures support stem cell proliferation? Exp Hematol. 1992; (1): 87-91
- Malignant transformation of NIH 3T3 fibroblasts by human c-sis is dependent upon the level of oncogene expression. Mol Carcinog. 1992; (4): 311-9
- The influence of extra-cellular matrix and stroma remodeling on the productivity of long-term human bone marrow cultures. Cytotechnology. 1992; (3): 217-24
- c-myb effects on kinetic events during MEL cell differentiation. Oncogene. 1992; (5): 901-7
- Biotinylated granulocyte/macrophage colony-stimulating factor analogues: effect of linkage chemistry on activity and binding. Bioconjug Chem. 1991 Nov-Dec; (6): 466-74
- Influence of medium exchange schedules on metabolic, growth, and GM-CSF secretion rates of genetically engineered NIH-3T3 cells. Biotechnol Prog. 1991 Jan-Feb; (1): 1-8
- In vitro myelopoiesis stimulated by rapid medium exchange and supplementation with hematopoietic growth factors. Blood. 1991; (12): 3155-61
- The construction of high efficiency human bone marrow tissue ex vivo. J Cell Biochem. 1991; (3): 268-72
- Alternative splicing of the human c-myb gene. Oncogene. 1990; (8): 1117-24
- Differentiation of mouse erythroleukemia cells enhanced by alternatively spliced c-myb mRNA. Science. 1990; (4974): 1291-3
- The proliferation of AML-193 is regulated by multiple hematopoietic growth factors and cytokines. Leukemia. 1989; (4): 314-5
- Constitutive expression of a c-myb cDNA blocks Friend murine erythroleukemia cell differentiation. Mol Cell Biol. 1988; (2): 884-92
- Activation of a novel KpnI transcript by downstream integration of a human T-lymphotropic virus type I provirus. J Biol Chem. 1986; (10): 4615-9
- Sequence-specific interaction of histones with the simian virus 40 enhancer region in vitro. J Biol Chem. 1985; (23): 12394-7
- Transformation of NIH 3T3 cells by a human c-sis cDNA clone. Nature. 1984 Mar 29-Apr 4; (5958): 464-7
- DNA methylation and expression of HLA-DR alpha. Mol Cell Biol. 1984; (5): 890-7
- Differential methylation of class I histocompatibility antigen genes in T-cell lines derived from two different types of T-cell malignancies. Leuk Res. 1984; (6): 965-73
- Identification of the human T cell lymphoma virus in B cell lines established from patients with adult T cell leukemia. J Clin Invest. 1984; (1): 56-62
- Methylation of human T-cell leukemia virus proviral DNA and viral RNA expression in short- and long-term cultures of infected cells. Virology. 1984; (1): 97-104
- Transforming potential of human c-sis nucleotide sequences encoding platelet-derived growth factor. Science. 1984; (4662): 636-9
- Homology of human T-cell leukaemia virus envelope gene with class I HLA gene. Nature. 1983 Sep 1-7; (5929): 60-2
- Presence of HTLV in a subset of T cells from an infected patient: some immunochemical properties of the infected cells. Haematol Blood Transfus. 1983: 459-61
- Relation of respiratory burst and arachidonate metabolism during phagocytosis by guinea pig alveolar macrophages. J Lab Clin Med. 1982; (6): 908-16
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