Seung K. Kim M.D., Ph.D.
Publications
- Neonatal β cell development in mice and humans is regulated by calcineurin/NFAT. Dev Cell. 2012; (1): 21-34
- PDGF signalling controls age-dependent proliferation in pancreatic β-cells. Nature. 2011; (7369): 349-55
- Specification of Drosophila corpora cardiaca neuroendocrine cells from mesoderm is regulated by Notch signaling. PLoS Genet. 2011; (8): e1002241
- Targeting SOX17 in human embryonic stem cells creates unique strategies for isolating and analyzing developing endoderm. Cell Stem Cell. 2011; (3): 335-46
- Calcineurin/NFAT signalling regulates pancreatic beta-cell growth and function. Nature. 2006; (7109): 345-9
- Conserved mechanisms of glucose sensing and regulation by Drosophila corpora cardiaca cells. Nature. 2004; (7006): 316-20
- Gene regulatory networks governing pancreas development. Dev Cell. 2013; (1): 5-13
- A molecular signature for purified definitive endoderm guides differentiation and isolation of endoderm from mouse and human embryonic stem cells. Stem Cells Dev. 2012; (12): 2273-87
- Deconstructing pancreas developmental biology. Cold Spring Harb Perspect Biol. 2012; (6)
- Gut insulin from Foxo1 loss. Nat Genet. 2012; (4): 363-4
- Extensive and coordinated transcription of noncoding RNAs within cell-cycle promoters. Nat Genet. 2011; (7): 621-9
- Deconstructing pancreas development to reconstruct human islets from pluripotent stem cells. Cell Stem Cell. 2010; (4): 300-8
- Polycomb protein Ezh2 regulates pancreatic beta-cell Ink4a/Arf expression and regeneration in diabetes mellitus. Genes Dev. 2009; (8): 975-85
- Characterization of six new human embryonic stem cell lines (HSF7, -8, -9, -10, -12, and -13) derived under minimal-animal component conditions. Stem Cells Dev. 2008; (3): 535-46
- Fluorescence-activated cell sorting purification of pancreatic progenitor cells. Diabetes Obes Metab. 2008: 179-85
- Conserved markers of fetal pancreatic epithelium permit prospective isolation of islet progenitor cells by FACS. Proc Natl Acad Sci U S A. 2007; (1): 175-80
- Glucose infusion in mice: a new model to induce beta-cell replication. Diabetes. 2007; (7): 1792-801
- Menin controls growth of pancreatic beta-cells in pregnant mice and promotes gestational diabetes mellitus. Science. 2007; (5851): 806-9
- Menin-mediated caspase 8 expression in suppressing multiple endocrine neoplasia type 1. J Biol Chem. 2007; (43): 31332-40
- Wnt signaling regulates pancreatic beta cell proliferation. Proc Natl Acad Sci U S A. 2007; (15): 6247-52
- Conditional expression of Smad7 in pancreatic beta cells disrupts TGF-beta signaling and induces reversible diabetes mellitus. PLoS Biol. 2006; (2): e39
- Intrinsic regulators of pancreatic beta-cell proliferation. Annu Rev Cell Dev Biol. 2006: 311-38
- NFAT dysregulation by increased dosage of DSCR1 and DYRK1A on chromosome 21. Nature. 2006; (7093): 595-600
- The ATP-sensitive potassium (KATP) channel-encoded dSUR gene is required for Drosophila heart function and is regulated by tinman. Proc Natl Acad Sci U S A. 2006; (32): 11999-2004
- Differentiation of insulin-producing cells from human neural progenitor cells. PLoS Med. 2005; (4): e103
- Menin regulates pancreatic islet growth by promoting histone methylation and expression of genes encoding p27Kip1 and p18INK4c. Proc Natl Acad Sci U S A. 2005; (41): 14659-64
- Embryonic stem cells and islet replacement in diabetes mellitus. Pediatr Diabetes. 2004: 5-15
- GDF11 modulates NGN3+ islet progenitor cell number and promotes beta-cell differentiation in pancreas development. Development. 2004; (24): 6163-74
- Ablation of insulin-producing neurons in flies: growth and diabetic phenotypes. Science. 2002; (5570): 1118-20
- Growth inhibitors promote differentiation of insulin-producing tissue from embryonic stem cells. Proc Natl Acad Sci U S A. 2002; (25): 16105-10
- Hedgehog signaling in gastrointestinal development and disease. Curr Mol Med. 2002; (1): 67-82
- Pancreatic islet cell replacement: successes and opportunities. Ann N Y Acad Sci. 2002: 41-3
- Pbx1 inactivation disrupts pancreas development and in Ipf1-deficient mice promotes diabetes mellitus. Nat Genet. 2002; (4): 430-5
- Signaling and transcriptional control of pancreatic organogenesis. Curr Opin Genet Dev. 2002; (5): 540-7
- Intercellular signals regulating pancreas development and function. Genes Dev. 2001; (2): 111-27
- Activin receptor patterning of foregut organogenesis. Genes Dev. 2000; (15): 1866-71
- Regulation of pancreas development by hedgehog signaling. Development. 2000; (22): 4905-13
- Screening for novel pancreatic genes expressed during embryogenesis. Diabetes. 1999; (8): 1550-6
- Notochord repression of endodermal Sonic hedgehog permits pancreas development. Genes Dev. 1998; (11): 1705-13
- Pancreas development is promoted by cyclopamine, a hedgehog signaling inhibitor. Proc Natl Acad Sci U S A. 1998; (22): 13036-41
- Notochord to endoderm signaling is required for pancreas development. Development. 1997; (21): 4243-52
- Pancreas development in the chick embryo. Cold Spring Harb Symp Quant Biol. 1997: 377-83
- Chemotherapy and neutropenia. Hematol Oncol Clin North Am. 1996; (2): 377-95
- Control of cell density and pattern by intercellular signaling in Myxococcus development. Annu Rev Microbiol. 1992: 117-39
- Intercellular signaling in Myxococcus development: the role of C factor. Trends Genet. 1991 Nov-Dec; (11-12): 361-5
- C-factor has distinct aggregation and sporulation thresholds during Myxococcus development. J Bacteriol. 1991; (5): 1722-8
- C-factor: a cell-cell signaling protein required for fruiting body morphogenesis of M. xanthus. Cell. 1990; (1): 19-26
- Cell alignment required in differentiation of Myxococcus xanthus. Science. 1990; (4971): 926-8
- Cell motility is required for the transmission of C-factor, an intercellular signal that coordinates fruiting body morphogenesis of Myxococcus xanthus. Genes Dev. 1990; (6): 896-904
- Purification and properties of Myxococcus xanthus C-factor, an intercellular signaling protein. Proc Natl Acad Sci U S A. 1990; (10): 3635-9
- Rho-dependent transcription termination of a bacterial operon is antagonized by an extrachromosomal gene product. Proc Natl Acad Sci U S A. 1986; (24): 9561-5
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