Steven Shafer
Publications
- In silico genetics: identification of a functional element regulating H2-Ealpha gene expression. Science. 2004; (5696): 690-5
- Mixed-effects modeling of the intrinsic ventilatory depressant potency of propofol in the non-steady state. Anesthesiology. 2004; (2): 240-50
- Pharmacodynamic interaction between propofol and remifentanil regarding hypnosis, tolerance of laryngoscopy, bispectral index, and electroencephalographic approximate entropy. Anesthesiology. 2004; (6): 1353-72
- A model of the ventilatory depressant potency of remifentanil in the non-steady state. Anesthesiology. 2003; (4): 779-87
- Using the time of maximum effect site concentration to combine pharmacokinetics and pharmacodynamics. Anesthesiology. 2003; (2): 324-33
- Propofol dosing regimens for ICU sedation based upon an integrated pharmacokinetic-pharmacodynamic model. Anesthesiology. 2001; (2): 324-33
- Response surface model for anesthetic drug interactions. Anesthesiology. 2000; (6): 1603-16
- The influence of age on propofol pharmacodynamics. Anesthesiology. 1999; (6): 1502-16
- Cerebrospinal fluid pharmacokinetics and pharmacodynamics of intrathecal neostigmine methylsulfate in humans. Anesthesiology. 1998; (5): 1074-88
- Population pharmacodynamics of midazolam administered by target controlled infusion in SICU patients after CABG surgery. Anesthesiology. 1998; (6): 1430-43
- Population pharmacokinetics of midazolam administered by target controlled infusion for sedation following coronary artery bypass grafting. Anesthesiology. 1998; (6): 1418-29
- The influence of method of administration and covariates on the pharmacokinetics of propofol in adult volunteers. Anesthesiology. 1998; (5): 1170-82
- Influence of age and gender on the pharmacokinetics and pharmacodynamics of remifentanil. I. Model development. Anesthesiology. 1997; (1): 10-23
- Pharmacokinetics and pharmacodynamics of remifentanil. II. Model application. Anesthesiology. 1997; (1): 24-33
- Remifentanil versus alfentanil: comparative pharmacokinetics and pharmacodynamics in healthy adult male volunteers. Anesthesiology. 1996; (4): 821-33
- Computer-controlled epidural infusion to targeted cerebrospinal fluid concentrations in humans. Clonidine. Anesthesiology. 1995; (1): 33-47
- Linearity of pharmacokinetics and model estimation of sufentanil. Anesthesiology. 1995; (6): 1194-204
- The pharmacokinetics of propofol in children using three different data analysis approaches. Anesthesiology. 1994; (1): 104-22
- The pharmacokinetics of the new short-acting opioid remifentanil (GI87084B) in healthy adult male volunteers. Anesthesiology. 1993; (5): 881-92
- Algorithms to rapidly achieve and maintain stable drug concentrations at the site of drug effect with a computer-controlled infusion pump. J Pharmacokinet Biopharm. 1992; (2): 147-69
- Application of semilinear canonical correlation to the measurement of opioid drug effect. J Pharmacokinet Biopharm. 1992; (6): 611-35
- Measuring the predictive performance of computer-controlled infusion pumps. J Pharmacokinet Biopharm. 1992; (1): 63-94
- Pharmacokinetics, pharmacodynamics, and rational opioid selection. Anesthesiology. 1991; (1): 53-63
- Pharmacokinetics of fentanyl administered by computer-controlled infusion pump. Anesthesiology. 1990; (6): 1091-102
- The prospective use of population pharmacokinetics in a computer-driven infusion system for alfentanil. Anesthesiology. 1990; (1): 66-72
- Absorption characteristics of transdermally administered fentanyl. Anesthesiology. 1989; (6): 928-34
- Influence of administration rate on propofol plasma-effect site equilibration. Anesthesiology. 2007; (3): 386-96
- A phase I, two-center study of the pharmacokinetics and pharmacodynamics of dexmedetomidine in children. Anesthesiology. 2006; (6): 1098-110
- Arterial and venous pharmacokinetics of ropivacaine with and without epinephrine after thoracic paravertebral block. Anesthesiology. 2005; (4): 704-11
- Differential activation of trigeminal C or Adelta nociceptors by infrared diode laser in rats: behavioral evidence. Brain Res. 2005; (1-2): 148-56
- Pharmacogenomics and drug development. Pharmacogenomics. 2005; (8): 857-64
- Variability of target-controlled infusion is less than the variability after bolus injection. Anesthesiology. 2005; (3): 639-45
- Application of Bispectral Index and Narcotrend index to the measurement of the electroencephalographic effects of isoflurane with and without burst suppression. Anesthesiology. 2004; (4): 847-54
- Determination of the pharmacodynamic interaction of propofol and remifentanil during esophagogastroduodenoscopy in children. Anesthesiology. 2004; (6): 1382-6
- Induction speed is not a determinant of propofol pharmacodynamics. Anesthesiology. 2004; (5): 1112-21
- Picking safe combinations. Anesthesiology. 2004; (6): 1260-1
- Shock values. Anesthesiology. 2004; (3): 567-8
- Spectral entropy as an electroencephalographic measure of anesthetic drug effect: a comparison with bispectral index and processed midlatency auditory evoked response. Anesthesiology. 2004; (1): 34-42
- Target controlled infusions: targeting the effect site while limiting peak plasma concentration. IEEE Trans Biomed Eng. 2004; (11): 1869-75
- Teaching application of clinical pharmacology skills using unusual observations from clozapine overdoses. J Clin Pharmacol. 2004; (2): 141-9
- Use of population modeling to define rational monitoring of amiodarone hepatic effects. Clin Pharmacol Ther. 2004; (4): 342-51
- Cephalad movement of morphine and fentanyl in humans after intrathecal injection. Anesthesiology. 2003; (1): 166-73
- Correlation of approximate entropy, bispectral index, and spectral edge frequency 95 (SEF95) with clinical signs of "anesthetic depth" during coadministration of propofol and remifentanil. Anesthesiology. 2003; (3): 621-7
- Isoflurane antagonizes the capacity of flurothyl or 1,2-dichlorohexafluorocyclobutane to impair fear conditioning to context and tone. Anesth Analg. 2003; (4): 1010-8, table of contents
- MAC Attack? Anesthesiology. 2003; (6): 1249-50
- Mathematical analysis of a pharmacodynamic model without plasma concentrations to extend its applicability. Med Hypotheses. 2003; (3): 453-7
- Piritramide and alfentanil display similar respiratory depressant potency. Acta Anaesthesiol Scand. 2003; (10): 1231-41
- Target-controlled infusions for intravenous anesthetics: surfing USA not! Anesthesiology. 2003; (5): 1039-41
- Artifact robustness, inter- and intraindividual baseline stability, and rational EEG parameter selection. Anesthesiology. 2002; (1): 54-9
- Efficient trial design for eliciting a pharmacokinetic-pharmacodynamic model-based response surface describing the interaction between two intravenous anesthetic drugs. Anesthesiology. 2002; (2): 400-8
- Non-steady state analysis of the pharmacokinetic interaction between propofol and remifentanil. Anesthesiology. 2002; (6): 1350-62
- Pharmacokinetic study of FFP photochemically treated with amotosalen (S-59) and UV light compared to FFP in healthy volunteers anticoagulated with warfarin. Transfusion. 2002; (10): 1302-7
- A double-blind, randomized comparison of i.v. lorazepam versus midazolam for sedation of ICU patients via a pharmacologic model. Anesthesiology. 2001; (2): 286-98
- Onset of propofol-induced burst suppression may be correctly detected as deepening of anaesthesia by approximate entropy but not by bispectral index. Br J Anaesth. 2001; (3): 505-7
- Bispectral index (BIS) and burst suppression: revealing a part of the BIS algorithm. J Clin Monit Comput. 2000; (8): 593-6
- Characterization of benzodiazepine receptors in the cerebellum. Prog Neuropsychopharmacol Biol Psychiatry. 2000; (6): 979-91
- Comparison of plasma compartment versus two methods for effect compartment--controlled target-controlled infusion for propofol. Anesthesiology. 2000; (2): 399-406
- Electromyographic activity falsely elevates the bispectral index. Anesthesiology. 2000; (5): 1485-7
- Hot air or full steam ahead? An empirical pharmacokinetic model of potent inhalational agents. Br J Anaesth. 2000; (4): 429-31
- Location, location, location. Anesthesiology. 2000; (3): 641-3
- Pharmacokinetics and pharmacodynamics of inhaled versus intravenous morphine in healthy volunteers. Anesthesiology. 2000; (3): 619-28
- Population pharmacokinetics of long-term oral amiodarone therapy. Clin Pharmacol Ther. 2000; (6): 642-52
- The pharmacology of anesthetic drugs in elderly patients. Anesthesiol Clin North America. 2000; (1): 1-29, v
- Unraveling the identity of benzodiazepine binding sites in rat hipppocampus and olfactory bulb. Eur J Pharmacol. 2000; (2-3): 167-76
- Drug interactions. Applications in fast-track anesthesia. Acta Anaesthesiol Belg. 1999; (4): 153-60
- Does size matter? Anesthesiology. 1998; (3): 557-60
- Pharmacokinetics and pharmacodynamics in anesthetic drug development. Acta Anaesthesiol Belg. 1998; (2): 65-78
- Pharmacokinetics of intravenous dynorphin A(1-13) in opioid-naive and opioid-treated human volunteers. Clin Pharmacol Ther. 1998; (1): 27-38
- Pharmacokinetics, cortisol release, and hemodynamics after intravenous and subcutaneous injection of human corticotropin-releasing factor in humans. Clin Pharmacol Ther. 1998; (5): 499-510
- Writing successful research proposals for medical science. Anesthesiology. 1998; (6): 1660-6
- A comparison of spectral edge, delta power, and bispectral index as EEG measures of alfentanil, propofol, and midazolam drug effect. Clin Pharmacol Ther. 1997; (1): 45-58
- Nomenclature for computer-assisted infusion devices. Anesthesiology. 1997; (6): 1430-1
- Urine and plasma catecholamine and cortisol concentrations after myocardial revascularization. Modulation by continuous sedation. Multicenter Study of Perioperative Ischemia (McSPI) Research Group, and the Ischemia Research and Education Foundation (IREF). Anesthesiology. 1997; (4): 785-96
- Comparative absorption kinetics of intramuscular midazolam and diazepam. Can J Anaesth. 1996; (5 Pt 1): 450-5
- Derivation and cross-validation of pharmacokinetic parameters for computer-controlled infusion of lidocaine in pain therapy. Anesthesiology. 1996; (5): 1043-50
- Inhalation versus intravenous anesthesia: a fictitious debate between E.I. Eger II and P.F. White. J Clin Anesth. 1996; (3 Suppl): 38S-41S
- Pharmacokinetic model-driven infusion of fentanyl in children. Anesthesiology. 1996; (6): 1268-75
- Pharmacokinetics of propofol in adult patients undergoing coronary revascularization. The Multicenter Study of Perioperative Ischemia Research Group. Anesthesiology. 1996; (6): 1288-97
- Semilinear canonical correlation applied to the measurement of the electroencephalographic effects of midazolam and flumazenil reversal. Anesthesiology. 1996; (3): 510-9
- Allometry of pharmacokinetics and pharmacodynamics of the muscle relaxant metocurine in mammals. Am J Physiol. 1995; (1 Pt 2): R85-91
- Biopharmaceutics of a new transdermal fentanyl device. Anesthesiology. 1995; (3): 459-69
- Clinical drug level predictions and practice. Int Anesthesiol Clin. 1995; (3): 91-100
- Evolving clinically useful predictors of recovery from intravenous anesthetics. Anesthesiology. 1995; (5): 902-5
- Pharmacodynamic modeling of the electroencephalographic effects of flumazenil in healthy volunteers sedated with midazolam. Clin Pharmacol Ther. 1995; (5): 567-82
- Pharmacokinetics of computer-controlled alfentanil administration in children undergoing cardiac surgery. Anesthesiology. 1995; (5): 944-55
- Pharmacokinetics of inhaled liposome-encapsulated fentanyl. Anesthesiology. 1995; (2): 277-84
- Prolonged alleviation of tactile allodynia by intravenous lidocaine in neuropathic rats. Anesthesiology. 1995; (4): 775-85
- Quantifying anesthetic drug interaction. Implications for drug dosing. Anesthesiology. 1995; (1): 1-5
- The pharmacokinetics of 8-methoxypsoralen following i.v. administration in humans. Br J Clin Pharmacol. 1995; (4): 347-60
- Validation of the alfentanil canonical univariate parameter as a measure of opioid effect on the electroencephalogram. Anesthesiology. 1995; (4): 747-56
- An efficient control strategy for dosage regimens. J Pharmacokinet Biopharm. 1994; (1): 73-94
- Comparison of some control strategies for three-compartment PK/PD models. J Pharmacokinet Biopharm. 1994; (6): 525-50
- Pharmacokinetic parameters relevant to recovery from opioids. Anesthesiology. 1994; (4): 833-42
- Pharmacokinetic-pharmacodynamic modeling in drug development: application to the investigational opioid trefentanil. Clin Pharmacol Ther. 1994; (3): 261-71
- Pharmacokinetics and pharmacodynamics of intraspinal dexmedetomidine in sheep. Anesthesiology. 1994; (6): 1349-59
- Cardiopulmonary and behavioral responses to computer-driven infusion of detomidine in standing horses. Am J Vet Res. 1993; (12): 2075-82
- Computer-controlled infusion of intravenous dexmedetomidine hydrochloride in adult human volunteers. Anesthesiology. 1993; (5): 821-8
- Constant versus optimal plasma concentrations. Anesth Analg. 1993; (3): 467-9
- Dexmedetomidine decreases cerebral blood flow velocity in humans. J Cereb Blood Flow Metab. 1993; (2): 350-3
- The pharmacokinetics and hemodynamic effects of intravenous and intramuscular dexmedetomidine hydrochloride in adult human volunteers. Anesthesiology. 1993; (5): 813-20
- Improving the clinical utility of anesthetic drug pharmacokinetics. Anesthesiology. 1992; (3): 327-30
- Plasma concentration clamping in the rat using a computer-controlled infusion pump. Pharm Res. 1992; (6): 800-7
- Thiopental pharmacodynamics. I. Defining the pseudo-steady-state serum concentration-EEG effect relationship. Anesthesiology. 1992; (2): 226-36
- Thiopental pharmacodynamics. II. Quantitation of clinical and electroencephalographic depth of anesthesia. Anesthesiology. 1992; (2): 237-44
- A simple analytical solution to the three-compartment pharmacokinetic model suitable for computer-controlled infusion pumps. IEEE Trans Biomed Eng. 1991; (6): 522-5
- A simple pocket calculator approach to predict anesthetic drug concentrations from pharmacokinetic data. Anesthesiology. 1990; (2): 332-6
- Estimating the rate of thiopental blood-brain equilibration using pseudo steady state serum concentrations. J Pharmacokinet Biopharm. 1990; (3): 175-87
- Quantitation of thiopental anesthetic depth with clinical stimuli. Can J Anaesth. 1990; (4 Pt 2): S18
- Two equally valid interpretations of the linear multicompartment mammillary pharmacokinetic model. J Pharm Sci. 1990; (4): 331-3
- A comparison of parametric with semiparametric analysis of the concentration versus effect relationship of metocurine in dogs and pigs. J Pharmacokinet Biopharm. 1989; (3): 291-304
- Exercise produces sensitivity to metocurine. Anesthesiology. 1989; (6): 973-7
- The longitudinal distribution of pulmonary vascular resistance during unilateral hypoxia. Anesthesiology. 1989; (3): 527-32
- Pharmacokinetics and pharmacodynamics of propofol infusions during general anesthesia. Anesthesiology. 1988; (3): 348-56
- Testing computer-controlled infusion pumps by simulation. Anesthesiology. 1988; (2): 261-6
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