C. Garrison Fathman
Publications
- Reduced DEAF1 function during type 1 diabetes inhibits translation in lymph node stromal cells by suppressing Eif4g3. J Mol Cell Biol. 2013; (2): 99-110
- Differential mTOR and ERK pathway utilization by effector CD4 T cells suggests combinatorial drug therapy of arthritis. Clin Immunol. 2012; (2): 127-38
- Exploiting a natural conformational switch to engineer an interleukin-2 'superkine'. Nature. 2012; (7395): 529-33
- New tools for classification and monitoring of autoimmune diseases. Nat Rev Rheumatol. 2012; (6): 317-28
- Therapeutic effects of systemic administration of chaperone αB-crystallin associated with binding proinflammatory plasma proteins. J Biol Chem. 2012; (13): 9708-21
- GRAIL: a unique mediator of CD4 T-lymphocyte unresponsiveness. FEBS J. 2011; (1): 47-58
- A model for harmonizing flow cytometry in clinical trials. Nat Immunol. 2010; (11): 975-8
- A short pulse of IL-4 delivered by DCs electroporated with modified mRNA can both prevent and treat autoimmune diabetes in NOD mice. Mol Ther. 2010; (12): 2112-20
- New technologies for autoimmune disease monitoring. Curr Opin Endocrinol Diabetes Obes. 2010; (4): 322-8
- Deaf1 isoforms control the expression of genes encoding peripheral tissue antigens in the pancreatic lymph nodes during type 1 diabetes. Nat Immunol. 2009; (9): 1026-33
- Lymphoid-tissue-specific homing of bone-marrow-derived dendritic cells. Blood. 2009; (26): 6638-47
- Naive CD4 t cell proliferation is controlled by mammalian target of rapamycin regulation of GRAIL expression. J Immunol. 2009; (10): 5919-28
- The transmembrane E3 ligase GRAIL ubiquitinates and degrades CD83 on CD4 T cells. J Immunol. 2009; (1): 438-44
- Cutting edge: The transmembrane E3 ligase GRAIL ubiquitinates the costimulatory molecule CD40 ligand during the induction of T cell anergy. J Immunol. 2008; (3): 1622-6
- The single subunit transmembrane E3 ligase gene related to anergy in lymphocytes (GRAIL) captures and then ubiquitinates transmembrane proteins across the cell membrane. J Biol Chem. 2008; (42): 28497-505
- Tissue- and age-specific changes in gene expression during disease induction and progression in NOD mice. Clin Immunol. 2008; (2): 195-201
- Tissue-targeted therapy of autoimmune diabetes using dendritic cells transduced to express IL-4 in NOD mice. Clin Immunol. 2008; (2): 176-87
- Multimodality imaging of T-cell hybridoma trafficking in collagen-induced arthritic mice: image-based estimation of the number of cells accumulating in mouse paws. J Biomed Opt. 2007 Nov-Dec; (6): 064025
- Molecular mechanisms of CD4+ T-cell anergy. Nat Rev Immunol. 2007; (8): 599-609
- Naive and memory T cells induce different types of graft-versus-host disease. J Immunol. 2007; (10): 6547-54
- A novel E3 ubiquitin ligase substrate screen identifies Rho guanine dissociation inhibitor as a substrate of gene related to anergy in lymphocytes. J Immunol. 2006; (11): 7559-66
- CYLD: deubiquitination-induced TCR signaling. Nat Immunol. 2006; (4): 369-70
- Cd4+Cd25+ regulatory T cells and their therapeutic potential. Annu Rev Med. 2006: 381-402
- Developing the concept of adoptive cellular gene therapy of rheumatoid arthritis. Autoimmun Rev. 2006; (2): 148-52
- T cell anergy: where it's LAT. Immunity. 2006; (5): 501-3
- An array of possibilities for the study of autoimmunity. Nature. 2005; (7042): 605-11
- Fostering interdisciplinary immunology Clinical Immunology. 2005: 1-2
- L-selectin and beta7 integrin on donor CD4 T cells are required for the early migration to host mesenteric lymph nodes and acute colitis of graft-versus-host disease. Blood. 2005; (12): 4009-15
- Molecular imaging using labeled donor tissues reveals patterns of engraftment, rejection, and survival in transplantation. Transplantation. 2005; (1): 134-9
- Only the CD62L+ subpopulation of CD4+CD25+ regulatory T cells protects from lethal acute GVHD. Blood. 2005; (5): 2220-6
- Protein microarrays for multiplex analysis of signal transduction pathways Nature Medicine. 2005: 1390-1396
- Targeted gene therapy of autoimmune diseases: advances and prospects. Expert Rev Clin Immunol. 2005; (3): 385-404
- Gene therapy for type 1 diabetes: a novel approach for targeted treatment of autoimmunity. J Clin Invest. 2004; (7): 892-4
- Murine CD4+CD25+ regulatory T cells fail to undergo chromatin remodeling across the proximal promoter region of the IL-2 gene. J Immunol. 2004; (8): 4994-5001
- Protein microarrays for multiplex analysis of signal transduction pathways. Nat Med. 2004; (12): 1390-6
- The gene related to anergy in lymphocytes, an E3 ubiquitin ligase, is necessary for anergy induction in CD4 T cells. J Immunol. 2004; (1): 79-85
- Two isoforms of otubain 1 regulate T cell anergy via GRAIL. Nat Immunol. 2004; (1): 45-54
- CD4+CD25+ regulatory T cells preserve graft-versus-tumor activity while inhibiting graft-versus-host disease after bone marrow transplantation. Nat Med. 2003; (9): 1144-50
- Costimulatory signals controlling regulatory T cells. Proc Natl Acad Sci U S A. 2003; (26): 15292-3
- GRAIL: an E3 ubiquitin ligase that inhibits cytokine gene transcription is expressed in anergic CD4+ T cells. Immunity. 2003; (4): 535-47
- Localized expression of an anti-TNF single-chain antibody prevents development of collagen-induced arthritis. Gene Ther. 2003; (15): 1248-57
- Scratching the (T cell) surface. Genome Biol. 2003; (1): 202
- Treatment of autoimmune disease by adoptive cellular gene therapy. Ann N Y Acad Sci. 2003: 512-9
- A complicated relationship: fulfilling the interactive needs of the T lymphocyte and the dendritic cell. Pharmacogenomics J. 2002; (6): 367-76
- Adoptive cellular gene therapy of autoimmune disease. Autoimmun Rev. 2002; (4): 213-9
- CD4 T-helper cells engineered to produce IL-10 prevent allergen-induced airway hyperreactivity and inflammation. J Allergy Clin Immunol. 2002; (3): 460-8
- Donor-type CD4(+)CD25(+) regulatory T cells suppress lethal acute graft-versus-host disease after allogeneic bone marrow transplantation. J Exp Med. 2002; (3): 389-99
- Immunomodulatory vaccination in autoimmune disease. Endocrinol Metab Clin North Am. 2002; (2): 441-56, viii-ix
- Retroviral gene therapy of collagen-induced arthritis by local delivery of IL-4. Clin Immunol. 2002; (3): 304-14
- Short polymers of arginine rapidly translocate into vascular cells: effects on nitric oxide synthesis. Circ J. 2002; (12): 1155-60
- The potential for gene therapy in the treatment of autoimmune disease. Clin Immunol. 2002; (3): 204-16
- The subpopulation of CD4+CD25+ splenocytes that delays adoptive transfer of diabetes expresses L-selectin and high levels of CCR7. J Immunol. 2002; (5): 2461-5
- Adoptive immunotherapy of experimental autoimmune encephalomyelitis via T cell delivery of the IL-12 p40 subunit. J Immunol. 2001; (4): 2379-87
- Antigen-specific T cell-mediated gene therapy in collagen-induced arthritis. J Clin Invest. 2001; (10): 1293-301
- Autoimmune diseases: genes, bugs and failed regulation. Nat Immunol. 2001; (9): 759-61
- Bioluminescence imaging of lymphocyte trafficking in vivo. Exp Hematol. 2001; (12): 1353-60
- CD4(+)CD25(+) T cells facilitate the induction of T cell anergy. J Immunol. 2001; (8): 4271-5
- Gene therapy in autoimmune disease. Curr Opin Immunol. 2001; (6): 676-82
- Immunization with DNA encoding an immunodominant peptide of insulin prevents diabetes in NOD mice. Clin Immunol. 2001; (2): 164-71
- Application of gene therapy in autoimmune disease. Curr Dir Autoimmun. 2000: 189-202
- Gene therapy for autoimmune disease. Clin Immunol. 2000; (1 Pt 2): S39-43
- Identification and characterization of the antigen-specific subpopulation of alloreactive CD4+ T cells in vitro and in vivo. Transplantation. 2000; (4): 605-9
- Polyarginine enters cells more efficiently than other polycationic homopolymers. J Pept Res. 2000; (5): 318-25
- Rapid and efficient vascular transport of arginine polymers inhibits myointimal hyperplasia. Circulation. 2000; (21): 2629-35
- T cell receptor (TCR)-mediated repertoire selection and loss of TCR vbeta diversity during the initiation of a CD4(+) T cell response in vivo. J Exp Med. 2000; (12): 1719-30
- Targeting rare populations of murine antigen-specific T lymphocytes by retroviral transduction for potential application in gene therapy for autoimmune disease. J Immunol. 2000; (7): 3581-90
- The application of gene therapy in autoimmune diseases. Gene Ther. 2000; (1): 9-13
- A new look at MHC and autoimmune disease. Science. 1999; (5415): 749, 751
- Isolation of self antigen-reactive cells from inflamed islets of nonobese diabetic mice using CD4high expression as a marker. J Immunol. 1999; (10): 5708-14
- Local delivery of TNF by retrovirus-transduced T lymphocytes exacerbates experimental autoimmune encephalomyelitis. Clin Immunol. 1999; (1): 10-4
- Suppressive immunization with DNA encoding a self-peptide prevents autoimmune disease: modulation of T cell costimulation. J Immunol. 1999; (6): 3336-41
- A gene therapy approach to treatment of autoimmune disease. Immunol Res. 1998; (1): 15-26
- Analysis of the role of variation of major histocompatibility complex class II expression on nonobese diabetic (NOD) peripheral T cell response. J Exp Med. 1998; (12): 2267-75
- Following antigen challenge, T cells up-regulate cell surface expression of CD4 in vitro and in vivo. J Immunol. 1998; (2): 714-20
- Prolongation of cardiac graft survival with anti-CD4Ig plus hCTLA4Ig in primates. J Surg Res. 1998; (2): 174-8
- Regulation of programmed cell death following T cell activation in vivo. Int Immunol. 1998; (2): 175-83
- T cell receptor (TCR) engagement leads to activation-induced splicing of tumor necrosis factor (TNF) nuclear pre-mRNA. J Exp Med. 1998; (2): 247-54
- The association of MHC with autoimmune diseases: understanding the pathogenesis of autoimmune diabetes. Clin Immunol Immunopathol. 1998; (1): 3-10
- CD45RBhigh CD4+ T cells from IFN-gamma knockout mice do not induce wasting disease. J Autoimmun. 1997; (5): 455-9
- Introduction of soluble proteins into the MHC class I pathway by conjugation to an HIV tat peptide. J Immunol. 1997; (4): 1666-8
- Local delivery of interleukin 4 by retrovirus-transduced T lymphocytes ameliorates experimental autoimmune encephalomyelitis. J Exp Med. 1997; (9): 1711-4
- Rat pancreatic islet and skin xenograft survival in CD4 and CD8 knockout mice. J Autoimmun. 1997; (3): 309-15
- The use of CD4 and CD8 knockout mice to study the role of T-cell subsets in allotransplant rejection. J Heart Lung Transplant. 1997; (3): 263-7
- Beta-cell destruction may be a late consequence of the autoimmune process in nonobese diabetic mice. Diabetes. 1996; (8): 1063-7
- Breaking self-tolerance in nonobese diabetic mice. J Exp Med. 1996; (4): 1657-62
- CD4+ but not CD8+ cells are essential for allorejection. J Exp Med. 1996; (5): 2013-8
- Immune regulation in type 1 diabetes. J Autoimmun. 1996; (2): 263-9
- Induction of tolerance to small bowel allografts in high-responder rats by combining anti-CD4 with CTLA4Ig. Transplantation. 1996; (11): 1537-9
- Mice with a disrupted IFN-gamma gene are susceptible to the induction of experimental autoimmune encephalomyelitis (EAE). J Immunol. 1996; (1): 5-7
- Monoclonal T cells identified in early NOD islet infiltrates. Immunity. 1996; (2): 189-94
- Pathogenic and protective roles of CD45RB(low) CD4+ cells correlate with cytokine profiles in the spontaneously autoimmune diabetic mouse. Diabetes. 1996; (1): 71-8
- Quantitative analysis of T cell activation: role of TCR/ligand density and TCR affinity. J Immunol. 1996; (8): 2737-42
- Treatment of experimental encephalomyelitis with a peptide analogue of myelin basic protein. Nature. 1996; (6563): 343-6
- CD4-positive suppressor cells block allotransplant rejection. J Immunol. 1995; (12): 6339-45
- Induction of tolerance to heart allografts in high responder rats by combining anti-CD4 with CTLA4Ig. J Immunol. 1995; (4): 1655-9
- Islet-infiltrating lymphocytes from prediabetic NOD mice rapidly transfer diabetes to NOD-scid/scid mice. Diabetes. 1995; (5): 550-4
- Ternary complex therapy for autoimmune disease. Hosp Pract (1995). 1995; (8): 57-8, 60-2, 64-5
- Tissue-specific effects of anti-CD4 therapy in induction of allograft unresponsiveness in high and low responder rats. Transpl Immunol. 1995; (3): 258-64
- CD4-positive/heat-stable antigen-positive thymocytes cause graft-versus-host disease across non-major histocompatibility complex incompatibilities. Eur J Immunol. 1994; (7): 1706-9
- Immunotherapeutic strategies directed at the trimolecular complex. Adv Immunol. 1994: 219-65
- Mechanisms of transplantation tolerance. Annu Rev Immunol. 1994: 707-34
- Prevention of diabetes and insulitis by neonatal intrathymic islet administration in NOD mice. J Autoimmun. 1994; (5): 549-60
- Regulation of autoimmune response. Curr Opin Immunol. 1994; (6): 946-55
- Anti-CD4 antibodies in diabetes. Immunol Ser. 1993: 237-52
- Evidence that anti-CD8 abrogates anti-CD4-mediated clonal anergy but allows allograft survival in mice. Transplantation. 1993; (1): 133-9
- Evidence that clonal anergy is induced in thymic migrant cells after anti-CD4-mediated transplantation tolerance. Transplantation. 1993; (3): 633-8
- Induction of relapsing paralysis in experimental autoimmune encephalomyelitis by bacterial superantigen. Nature. 1993; (6447): 642-4
- Peptides as therapy of autoimmune disease. Diabetes Metab Rev. 1993; (4): 239-44
- Requirement for CD8+ cells in T cell receptor peptide-induced clonal unresponsiveness. Science. 1993; (5091): 91-4
- SEB induced anergy: modulation of immune response to T cell determinants of myoglobin and myelin basic protein. J Immunol. 1993; (7): 3062-9
- Selection for amino acid sequence and J beta element usage in the beta chain of DBA/2V beta b- and DBA/2V beta a-derived myoglobin-specific T cell clones. J Immunol. 1993; (11): 6185-94
- The use of granzyme A as a marker of heart transplant rejection in cyclosporine or anti-CD4 monoclonal antibody-treated rats. Transplantation. 1993; (1): 146-53
- Amelioration of autoimmune encephalomyelitis by myelin basic protein synthetic peptide-induced anergy. Science. 1992; (5087): 1491-4
- Anti-CD4 monoclonal antibodies in therapy: creation of nonclassical tolerance in the adult. Immunol Rev. 1992: 105-30
- Immunotherapy of rheumatic diseases based on understanding genetic predisposition to the development of these diseases. Rheum Dis Clin North Am. 1992; (4): 915-26
- Limited T cell receptor beta-chain usage in the sperm whale myoglobin 110-121/E alpha dA beta d response by H-2d congenic mouse strains. J Immunol. 1992; (7): 2323-7
- Presentation of antigen by mixed isotype class II molecules in normal H-2d mice. J Exp Med. 1992; (1): 157-62
- What a rheumatologist needs to know about T cell receptor structure and function. J Rheumatol Suppl. 1992: 12-5; discussion 15-7
- Analysis of the ternary complex of antigen, MHC and T-cell receptor: the influence of the T-cell receptor V beta repertoire on the V beta gene element usage. Res Immunol. 1991 Jun-Aug; (5-6): 491-3
- Anti-CD4 mediates clonal anergy during transplantation tolerance induction. J Exp Med. 1991; (2): 491-4
- Anti-CD8 abrogates effect of anti-CD4-mediated islet allograft survival in rat model. Diabetes. 1991; (11): 1430-4
- Genetic analysis of diabetes in the nonobese diabetic mouse. I. MHC and T cell receptor beta gene expression. J Immunol. 1991; (2): 529-34
- Genetic dissection of T cell receptor V beta gene requirements for spontaneous murine diabetes. J Exp Med. 1991; (3): 633-8
- Molecular analysis of the role of the HLA class II genes DRB1, DQA1, DQB1, and DPB1 in susceptibility to Lyme arthritis. Hum Immunol. 1991; (1): 20-7
- The T cell receptor repertoire influences V beta element usage in response to myoglobin. J Exp Med. 1991; (1): 83-92
- Induction of donor-specific unresponsiveness to cardiac allografts in rats by pretransplant anti-CD4 monoclonal antibody therapy. Transplantation. 1990; (3): 366-73
- Shared molecular markers of genetic predisposition to seropositive rheumatoid arthritis. Hum Immunol. 1990; (2): 90-9
- T cell receptor-mediated negative selection of autoreactive T lymphocyte precursors occurs after commitment to the CD4 or CD8 lineages. J Exp Med. 1990; (3): 835-45
- The presumptive CDR3 regions of both T cell receptor alpha and beta chains determine T cell specificity for myoglobin peptides. J Exp Med. 1990; (1): 27-33
- A subset of memory CD4+ helper T lymphocytes identified by expression of Pgp-1. J Exp Med. 1989; (4): 1461-6
- Cardiac allograft prolongation in mice treated with combined posttransplantation total-lymphoid irradiation and anti-L3T4 antibody therapy. Transplantation. 1989; (4): 587-91
- Enhanced cell-mediated protection against fatal Escherichia coli septicemia induced by treatment with recombinant IL-2. J Immunol. 1989; (4): 1134-8
- A new look at the shared epitope hypothesis. Am J Med. 1988; (6A): 20-2
- Immunotherapy of the nonobese diabetic mouse: treatment with an antibody to T-helper lymphocytes. Science. 1988; (4852): 659-62
- Use of anti-L3T4 and anti-Ia treatments for prolongation of xenogeneic islet transplants. Transplantation. 1988; (2): 210-5
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