Jeffrey Axelrod

Publications

• Microtubules enable the planar cell polarity of airway cilia. Vladar EK, Bayly RD, Sangoram AM, Scott MP, Axelrod JD. Curr Biol. 2012; 22 (23): 2203-12
• Multicilin promotes centriole assembly and ciliogenesis during multiciliate cell differentiation. Stubbs JL, Vladar EK, Axelrod JD, Kintner C. Nat Cell Biol. 2012; 14 (2): 140-7
• Planar polarized protrusions break the symmetry of EGFR signaling during Drosophila bract cell fate induction. Peng Y, Han C, Axelrod JD. Dev Cell. 2012; 23 (3): 507-18
• Asymmetric homotypic interactions of the atypical cadherin flamingo mediate intercellular polarity signaling. Chen WS, Antic D, Matis M, Logan CY, Povelones M, Anderson GA, Nusse R, Axelrod JD. Cell. 2008; 133 (6): 1093-105
• Cell packing influences planar cell polarity signaling. Ma D, Amonlirdviman K, Raffard RL, Abate A, Tomlin CJ, Axelrod JD. Proc Natl Acad Sci U S A. 2008; 105 (48): 18800-5
• Mathematical modeling of planar cell polarity to understand domineering nonautonomy. Amonlirdviman K, Khare NA, Tree DR, Chen WS, Axelrod JD, Tomlin CJ. Science. 2005; 307 (5708): 423-6
• A mathematical model to study the dynamics of epithelial cellular networks. Abate A, Vincent S, Dobbe R, Silletti A, Master N, Axelrod JD, Tomlin CJ. IEEE/ACM Trans Comput Biol Bioinform. 2012 Nov-Dec; 9 (6): 1607-20
• A universal analysis tool for the detection of asymmetric signal distribution in microscopic images. Matis M, Axelrod JD, Galic M. Dev Dyn. 2012; 241 (8): 1301-9
• Asymmetric protein localization in planar cell polarity: mechanisms, puzzles, and challenges. Peng Y, Axelrod JD. Curr Top Dev Biol. 2012: 101 33-53
• Nuclear localization of Prickle2 is required to establish cell polarity during early mouse embryogenesis. Tao H, Inoue K, Kiyonari H, Bassuk AG, Axelrod JD, Sasaki H, Aizawa S, Ueno N. Dev Biol. 2012; 364 (2): 138-48
• Remodeling a tissue: subtraction adds insight. Axelrod JD, Sci Signal. 2012; 5 (252): pe52
• Modeling the control of planar cell polarity. Axelrod JD, Tomlin CJ. Wiley Interdiscip Rev Syst Biol Med. 2011 Sep-Oct; 3 (5): 588-605
• Mutations in prickle orthologs cause seizures in flies, mice, and humans. Tao H, Manak JR, Sowers L, Mei X, Kiyonari H, Abe T, Dahdaleh NS, Yang T, Wu S, Chen S, Fox MH, Gurnett C, Montine T, Bird T, Shaffer LG, Rosenfeld JA, McConnell J, Madan-Khetarpal S, Berry-Kravis E, Griesbach H, Saneto RP, Scott MP, Antic D, Reed J, Boland R, Ehaideb SN, El-Shanti H, Mahajan VB, Ferguson PJ, Axelrod JD, Lehesjoki AE, Fritzsch B, Slusarski DC, Wemmie J, Ueno N, Bassuk AG. Am J Hum Genet. 2011; 88 (2): 138-49
• Pointing in the right direction: new developments in the field of planar cell polarity. Bayly R, Axelrod JD. Nat Rev Genet. 2011; 12 (6): 385-91
• Versatile spectral methods for point set matching Silletti, A., Abate, A., Axlrod, J.D., Tomlin, C.J.. Pattern Recognition Letters. 2011; 32 (5): 731-739
• Delivering the lateral inhibition punchline: it's all about the timing. Axelrod JD, Sci Signal. 2010; 3 (145): pe38
• Planar cell polarity enables posterior localization of nodal cilia and left-right axis determination during mouse and Xenopus embryogenesis. Antic D, Stubbs JL, Suyama K, Kintner C, Scott MP, Axelrod JD. PLoS One. 2010; 5 (2): e8999
• Bone morphogenetic protein 2 induces pulmonary angiogenesis via Wnt-beta-catenin and Wnt-RhoA-Rac1 pathways. de Jesus Perez VA, Alastalo TP, Wu JC, Axelrod JD, Cooke JP, Amieva M, Rabinovitch M. J Cell Biol. 2009; 184 (1): 83-99
• Planar cell polarity signaling: the developing cell's compass. Vladar EK, Antic D, Axelrod JD. Cold Spring Harb Perspect Biol. 2009; 1 (3): a002964
• Progress and challenges in understanding planar cell polarity signaling. Axelrod JD, Semin Cell Dev Biol. 2009; 20 (8): 964-71
• Studies of epithelial PCP. Axelrod JD, Semin Cell Dev Biol. 2009; 20 (8): 956
• A homozygous mutation in human PRICKLE1 causes an autosomal-recessive progressive myoclonus epilepsy-ataxia syndrome. Bassuk AG, Wallace RH, Buhr A, Buller AR, Afawi Z, Shimojo M, Miyata S, Chen S, Gonzalez-Alegre P, Griesbach HL, Wu S, Nashelsky M, Vladar EK, Antic D, Ferguson PJ, Cirak S, Voit T, Scott MP, Axelrod JD, Gurnett C, Daoud AS, Kivity S, Neufeld MY, Mazarib A, Straussberg R, Walid S, Korczyn AD, Slusarski DC, Berkovic SF, El-Shanti HI. Am J Hum Genet. 2008; 83 (5): 572-81
• An Adjoint-based Parameter Identifcation Algorithm applied to Planar Cell Polarity Signaling Raffard, R., Amonlirdviman, K., Axelrod, J.D., Tomlin, C.J.. Joint Issue of IEEE Transactions on Circuits and Systems and IEEE Transactions on Automatic Control. 2008: January 109-121
• Bad hair days for mouse PCP mutants. Axelrod JD, Nat Cell Biol. 2008; 10 (11): 1251-3
• Basal bodies, kinocilia and planar cell polarity. Axelrod JD, Nat Genet. 2008; 40 (1): 10-1
• Dishevelled links basal body docking and orientation in ciliated epithelial cells. Vladar EK, Axelrod JD. Trends Cell Biol. 2008; 18 (11): 517-20
• Hedgehog and Wingless stabilize but do not induce cell fate during Drosophila dorsal embryonic epidermal patterning. Vincent S, Perrimon N, Axelrod JD. Development. 2008; 135 (16): 2767-75
• Asymmetric distribution of prickle-like 2 reveals an early underlying polarization of vestibular sensory epithelia in the inner ear. Deans MR, Antic D, Suyama K, Scott MP, Axelrod JD, Goodrich LV. J Neurosci. 2007; 27 (12): 3139-47
• Biology by numbers: mathematical modelling in developmental biology. Tomlin CJ, Axelrod JD. Nat Rev Genet. 2007; 8 (5): 331-40
• The Drosophila casein kinase Iepsilon/delta Discs overgrown promotes cell survival via activation of DIAP1 expression. Guan J, Li H, Rogulja A, Axelrod JD, Cadigan KM. Dev Biol. 2007; 303 (1): 16-28
• A WNTer wonderland in Snowbird. He X, Axelrod JD. Development. 2006; 133 (14): 2597-603
• Cell shape in proliferating epithelia: a multifaceted problem. Axelrod JD, Cell. 2006; 126 (4): 643-5
• D2 dopamine receptors colocalize regulator of G-protein signaling 9-2 (RGS9-2) via the RGS9 DEP domain, and RGS9 knock-out mice develop dyskinesias associated with dopamine pathways. Kovoor A, Seyffarth P, Ebert J, Barghshoon S, Chen CK, Schwarz S, Axelrod JD, Cheyette BN, Simon MI, Lester HA, Schwarz J. J Neurosci. 2005; 25 (8): 2157-65
• Understanding biology by reverse engineering the control. Tomlin CJ, Axelrod JD. Proc Natl Acad Sci U S A. 2005; 102 (12): 4219-20
• A second canon. Functions and mechanisms of beta-catenin-independent Wnt signaling. Veeman MT, Axelrod JD, Moon RT. Dev Cell. 2003; 5 (3): 367-77
• Fidelity in planar cell polarity signalling. Ma D, Yang CH, McNeill H, Simon MA, Axelrod JD. Nature. 2003; 421 (6922): 543-7
• A three-tiered mechanism for regulation of planar cell polarity. Tree DR, Ma D, Axelrod JD. Semin Cell Dev Biol. 2002; 13 (3): 217-24
• Coupling planar cell polarity signaling to morphogenesis. Axelrod JD, McNeill H. ScientificWorldJournal. 2002: 2 434-54
• Prickle mediates feedback amplification to generate asymmetric planar cell polarity signaling. Tree DR, Shulman JM, Rousset R, Scott MP, Gubb D, Axelrod JD. Cell. 2002; 109 (3): 371-81
• Regulation of Frizzled by fat-like cadherins during planar polarity signaling in the Drosophila compound eye. Yang CH, Axelrod JD, Simon MA. Cell. 2002; 108 (5): 675-88
• Strabismus comes into focus. Axelrod JD, Nat Cell Biol. 2002; 4 (1): E6-8
• Drosophila Rho-associated kinase (Drok) links Frizzled-mediated planar cell polarity signaling to the actin cytoskeleton. Winter CG, Wang B, Ballew A, Royou A, Karess R, Axelrod JD, Luo L. Cell. 2001; 105 (1): 81-91
• Naked cuticle targets dishevelled to antagonize Wnt signal transduction. Rousset R, Mack JA, Wharton KA, Axelrod JD, Cadigan KM, Fish MP, Nusse R, Scott MP. Genes Dev. 2001; 15 (6): 658-71
• Unipolar membrane association of Dishevelled mediates Frizzled planar cell polarity signaling. Axelrod JD, Genes Dev. 2001; 15 (10): 1182-7
• Differential recruitment of Dishevelled provides signaling specificity in the planar cell polarity and Wingless signaling pathways. Axelrod JD, Miller JR, Shulman JM, Moon RT, Perrimon N. Genes Dev. 1998; 12 (16): 2610-22
• Frizzled signaling and the developmental control of cell polarity. Shulman JM, Perrimon N, Axelrod JD. Trends Genet. 1998; 14 (11): 452-8
• Conservation of dishevelled structure and function between flies and mice: isolation and characterization of Dvl2. Klingensmith J, Yang Y, Axelrod JD, Beier DR, Perrimon N, Sussman DJ. Mech Dev. 1996; 58 (1-2): 15-26
• Interaction between Wingless and Notch signaling pathways mediated by dishevelled. Axelrod JD, Matsuno K, Artavanis-Tsakonas S, Perrimon N. Science. 1996; 271 (5257): 1826-32
• The wingless signaling pathway is directly involved in Drosophila heart development. Park M, Wu X, Golden K, Axelrod JD, Bodmer R. Dev Biol. 1996; 177 (1): 104-16
• wingless refines its own expression domain on the Drosophila wing margin. Rulifson EJ, Micchelli CA, Axelrod JD, Perrimon N, Blair SS. Nature. 1996; 384 (6604): 72-4
• The collection and evaluation of peripheral blood progenitor cells sufficient for repetitive cycles of high-dose chemotherapy support. Benjamin RJ, Linsley L, Axelrod JD, Churchill WH, Sieff C, Shulman LN, Elias A, Ayash L, Malachowski ME, Uhl L. Transfusion. 1995; 35 (10): 837-44
• GAL4 disrupts a repressing nucleosome during activation of GAL1 transcription in vivo. Axelrod JD, Reagan MS, Majors J. Genes Dev. 1993; 7 (5): 857-69
• Proline-independent binding of PUT3 transcriptional activator protein detected by footprinting in vivo. Axelrod JD, Majors J, Brandriss MC. Mol Cell Biol. 1991; 11 (1): 564-7
• An improved method for photofootprinting yeast genes in vivo using Taq polymerase. Axelrod JD, Majors J. Nucleic Acids Res. 1989; 17 (1): 171-83
• Vitamin D affects proliferation of a murine T helper cell clone. Lacey DL, Axelrod J, Chappel JC, Kahn AJ, Teitelbaum SL. J Immunol. 1987; 138 (6): 1680-6
• Unique cytochalasin B binding characteristics of the hepatic glucose carrier. Axelrod JD, Pilch PF. Biochemistry. 1983; 22 (9): 2222-7
• Unimpaired signal transduction by the adipocyte insulin receptor following its partial proteolytic fragmentation. Pilch PF, Axelrod JD, Colello J, Czech MP. J Biol Chem. 1981; 256 (4): 1570-5