Stephen Galli
Publications
- Evidence that mast cells are not required for healing of splinted cutaneous excisional wounds in mice. PLoS One. 2013; (3): e59167
- Mast cell anaphylatoxin receptor expression can enhance IgE-dependent skin inflammation in mice. J Allergy Clin Immunol. 2013; (2): 541-8.e1-9
- PLA2G3 promotes mast cell maturation and function. Nat Immunol. 2013; (6): 527-9
- Critical role of P1-Runx1 in mouse basophil development. Blood. 2012; (1): 76-85
- Evidence questioning cromolyn's effectiveness and selectivity as a 'mast cell stabilizer' in mice. Lab Invest. 2012; (10): 1472-82
- IgE and mast cells in allergic disease. Nat Med. 2012; (5): 693-704
- Modulation of mTOR effector phosphoproteins in blood basophils from allergic patients. J Clin Immunol. 2012; (3): 565-73
- New models for analyzing mast cell functions in vivo. Trends Immunol. 2012; (12): 613-25
- The chymase mouse mast cell protease 4 degrades TNF, limits inflammation, and promotes survival in a model of sepsis. Am J Pathol. 2012; (3): 875-86
- Antiinflammatory and immunosuppressive functions of mast cells. Methods Mol Biol. 2011: 207-20
- Basophil CD203c levels are increased at baseline and can be used to monitor omalizumab treatment in subjects with nut allergy. Int Arch Allergy Immunol. 2011; (4): 318-27
- Identification of an IFN-γ/mast cell axis in a mouse model of chronic asthma. J Clin Invest. 2011; (8): 3133-43
- Mast cell chymase reduces the toxicity of Gila monster venom, scorpion venom, and vasoactive intestinal polypeptide in mice. J Clin Invest. 2011; (10): 4180-91
- Mast cells and immunoregulation/immunomodulation. Adv Exp Med Biol. 2011: 186-211
- Phenotypic and functional plasticity of cells of innate immunity: macrophages, mast cells and neutrophils. Nat Immunol. 2011; (11): 1035-44
- Reduced mast cell and basophil numbers and function in Cpa3-Cre; Mcl-1fl/fl mice. Blood. 2011; (26): 6930-8
- Anaphylaxis: mechanisms of mast cell activation. Chem Immunol Allergy. 2010: 45-66
- Distinguishing mast cell and granulocyte differentiation at the single-cell level. Cell Stem Cell. 2010; (4): 361-8
- Evidence that vitamin D(3) promotes mast cell-dependent reduction of chronic UVB-induced skin pathology in mice. J Exp Med. 2010; (3): 455-63
- Mast cell-derived TNF can exacerbate mortality during severe bacterial infections in C57BL/6-KitW-sh/W-sh mice. Am J Pathol. 2010; (2): 926-38
- Mast cells in allergy and infection: versatile effector and regulatory cells in innate and adaptive immunity. Eur J Immunol. 2010; (7): 1843-51
- Regulation of secretory granule size by the precise generation and fusion of unit granules. J Cell Mol Med. 2010; (7): 1904-16
- The role of recipient mast cells in acute and chronic cardiac allograft rejection in C57BL/6-KitW-sh/W-sh mice. J Heart Lung Transplant. 2010; (4): 401-9
- Thymic stromal lymphopoietin contributes to myeloid hyperplasia and increased immunoglobulins, but not epidermal hyperplasia, in RabGEF1-deficient mice. Am J Pathol. 2010; (5): 2411-20
- Pillars article: fate of bone marrow-derived cultured mast cells after intracutaneous, intraperitoneal, and intravenous transfer into genetically mast cell-deficient w/wv mice. Evidence that cultured mast cells can give rise to both connective tissue type and mucosal mast cells. J Immunol. 2009; (11): 6863-81
- Basophils are back! Immunity. 2008; (4): 495-7
- IL-3 is required for increases in blood basophils in nematode infection in mice and can enhance IgE-dependent IL-4 production by basophils in vitro. Lab Invest. 2008; (11): 1134-42
- Immunomodulatory mast cells: negative, as well as positive, regulators of immunity. Nat Rev Immunol. 2008; (6): 478-86
- Mast cell-expressed orphan receptor CCRL2 binds chemerin and is required for optimal induction of IgE-mediated passive cutaneous anaphylaxis. J Exp Med. 2008; (10): 2207-20
- Mast cells: versatile regulators of inflammation, tissue remodeling, host defense and homeostasis. J Dermatol Sci. 2008; (1): 7-19
- Neurotensin increases mortality and mast cells reduce neurotensin levels in a mouse model of sepsis. Nat Med. 2008; (4): 392-8
- New developments in mast cell biology. Nat Immunol. 2008; (11): 1215-23
- Rabaptin-5 regulates receptor expression and functional activation in mast cells. Blood. 2008; (10): 4148-57
- The development of allergic inflammation. Nature. 2008; (7203): 445-54
- IL-33 can promote survival, adhesion and cytokine production in human mast cells. Lab Invest. 2007; (10): 971-8
- IL-33 induces IL-13 production by mouse mast cells independently of IgE-FcepsilonRI signals. J Leukoc Biol. 2007; (6): 1481-90
- Mast cell-derived TNF can promote Th17 cell-dependent neutrophil recruitment in ovalbumin-challenged OTII mice. Blood. 2007; (9): 3640-8
- Mast cell-derived TNF contributes to airway hyperreactivity, inflammation, and TH2 cytokine production in an asthma model in mice. J Allergy Clin Immunol. 2007; (1): 48-55
- Mast cell-derived interleukin 10 limits skin pathology in contact dermatitis and chronic irradiation with ultraviolet B. Nat Immunol. 2007; (10): 1095-104
- Mast cells in the promotion and limitation of chronic inflammation. Immunol Rev. 2007: 304-28
- Roles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI surface expression and Fc epsilon RI-dependent responses in mast cells. Blood. 2007; (12): 5308-17
- TIM-1 and TIM-3 enhancement of Th2 cytokine production by mast cells. Blood. 2007; (7): 2565-8
- TNF can contribute to multiple features of ovalbumin-induced allergic inflammation of the airways in mice. J Allergy Clin Immunol. 2007; (3): 680-6
- A key regulatory role for histamine in experimental autoimmune encephalomyelitis: disease exacerbation in histidine decarboxylase-deficient mice. J Immunol. 2006; (1): 17-26
- Effector and potential immunoregulatory roles of mast cells in IgE-associated acquired immune responses. Curr Opin Immunol. 2006; (6): 751-60
- Mast cell-associated TNF promotes dendritic cell migration. J Immunol. 2006; (7): 4102-12
- Mast cell-derived tumor necrosis factor can promote nerve fiber elongation in the skin during contact hypersensitivity in mice. Am J Pathol. 2006; (5): 1713-21
- Mast cells can enhance resistance to snake and honeybee venoms. Science. 2006; (5786): 526-30
- Mast cells can promote the development of multiple features of chronic asthma in mice. J Clin Invest. 2006; (6): 1633-41
- Mast cells enhance T cell activation: importance of mast cell costimulatory molecules and secreted TNF. J Immunol. 2006; (4): 2238-48
- RabGEF1 regulates stem cell factor/c-Kit-mediated signaling events and biological responses in mast cells. Proc Natl Acad Sci U S A. 2006; (8): 2659-64
- Second symposium on the definition and management of anaphylaxis: summary report--Second National Institute of Allergy and Infectious Disease/Food Allergy and Anaphylaxis Network symposium. J Allergy Clin Immunol. 2006; (2): 391-7
- Activity of the tyrosine kinase inhibitor PKC412 in a patient with mast cell leukemia with the D816V KIT mutation. Blood. 2005; (8): 2865-70
- Decreased susceptibility of mast cell-deficient Kit(W)/Kit(W-v) mice to the development of 1, 2-dimethylhydrazine-induced intestinal tumors. Lab Invest. 2005; (3): 388-96
- Identification of mast cell progenitors in adult mice. Proc Natl Acad Sci U S A. 2005; (32): 11408-13
- Mast cell-deficient W-sash c-kit mutant Kit W-sh/W-sh mice as a model for investigating mast cell biology in vivo. Am J Pathol. 2005; (3): 835-48
- Mast cells as "tunable" effector and immunoregulatory cells: recent advances. Annu Rev Immunol. 2005: 749-86
- Mast cells enhance T cell activation: Importance of mast cell-derived TNF. Proc Natl Acad Sci U S A. 2005; (18): 6467-72
- Mast cells in the development of adaptive immune responses. Nat Immunol. 2005; (2): 135-42
- Monomeric IgE enhances human mast cell chemokine production: IL-4 augments and dexamethasone suppresses the response. J Allergy Clin Immunol. 2005; (6): 1357-63
- Pathogenesis and management of anaphylaxis: current status and future challenges. J Allergy Clin Immunol. 2005; (3): 571-4
- RabGEF1, a negative regulator of Ras signalling, mast cell activation and skin inflammation. Novartis Found Symp. 2005: 115-24; discussion 124-30, 145-51
- Symposium on the definition and management of anaphylaxis: summary report. J Allergy Clin Immunol. 2005; (3): 584-91
- Chair's introduction. Anaphylaxis. Novartis Found Symp. 2004: 1-5
- Immune sensitization in the skin is enhanced by antigen-independent effects of IgE. Immunity. 2004; (4): 381-92
- Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. Nature. 2004; (7016): 512-6
- RabGEF1 is a negative regulator of mast cell activation and skin inflammation. Nat Immunol. 2004; (8): 844-52
- Evidence that IgE molecules mediate a spectrum of effects on mast cell survival and activation via aggregation of the FcepsilonRI. Proc Natl Acad Sci U S A. 2003; (22): 12911-6
- Identification of A3 receptor- and mast cell-dependent and -independent components of adenosine-mediated airway responsiveness in mice. J Immunol. 2003; (1): 331-7
- Involvement of both 'allergic' and 'autoimmune' mechanisms in EAE, MS and other autoimmune diseases. Trends Immunol. 2003; (9): 479-84
- Multiple elements of the allergic arm of the immune response modulate autoimmune demyelination. Proc Natl Acad Sci U S A. 2003; (4): 1867-72
- Severe anaphylactic reactions to glutamic acid decarboxylase (GAD) self peptides in NOD mice that spontaneously develop autoimmune type 1 diabetes mellitus. BMC Immunol. 2003: 2
- Gene-microarray analysis of multiple sclerosis lesions yields new targets validated in autoimmune encephalomyelitis. Nat Med. 2002; (5): 500-8
- Probing the roles of mast cells and basophils in natural and acquired immunity, physiology and disease. Trends Immunol. 2002; (9): 425-7
- Regulation of mast-cell and basophil function and survival by IgE. Nat Rev Immunol. 2002; (10): 773-86
- Transcriptional response of human mast cells stimulated via the Fc(epsilon)RI and identification of mast cells as a source of IL-11. BMC Immunol. 2002: 5
- An unexpected version of horror autotoxicus: anaphylactic shock to a self-peptide. Nat Immunol. 2001; (3): 216-22
- Regulation of mast cell survival by IgE. Immunity. 2001; (6): 791-800
- A role for Bax in the regulation of apoptosis in mouse mast cells. J Invest Dermatol. 2000; (6): 1205-6
- In vivo immunological function of mast cells derived from embryonic stem cells: an approach for the rapid analysis of even embryonic lethal mutations in adult mice in vivo. Proc Natl Acad Sci U S A. 2000; (16): 9186-90
- Mast cells and basophils. Curr Opin Hematol. 2000; (1): 32-9
- Mast cells can amplify airway reactivity and features of chronic inflammation in an asthma model in mice. J Exp Med. 2000; (3): 455-62
- The diverse potential effector and immunoregulatory roles of mast cells in allergic disease. J Allergy Clin Immunol. 2000; (5): 847-59
- IgE enhances Fc epsilon receptor I expression and IgE-dependent release of histamine and lipid mediators from human umbilical cord blood-derived mast cells: synergistic effect of IL-4 and IgE on human mast cell Fc epsilon receptor I expression and mediator release. J Immunol. 1999; (9): 5455-65
- Mast cells as sentinels of innate immunity. Curr Opin Immunol. 1999; (1): 53-9
- Mast-cell heparin demystified. Nature. 1999; (6746): 714-5
- Spontaneous canine mast cell tumors express tandem duplications in the proto-oncogene c-kit. Exp Hematol. 1999; (4): 689-97
- Involvement of Bruton's tyrosine kinase in FcepsilonRI-dependent mast cell degranulation and cytokine production. J Exp Med. 1998; (8): 1235-47
- Involvement of interleukin-3 in delayed-type hypersensitivity. Blood. 1998; (3): 778-83
- Mast cells can secrete vascular permeability factor/ vascular endothelial cell growth factor and exhibit enhanced release after immunoglobulin E-dependent upregulation of fc epsilon receptor I expression. J Exp Med. 1998; (6): 1135-45
- P- and E-selectins are required for the leukocyte recruitment, but not the tissue swelling, associated with IgE- and mast cell-dependent inflammation in mouse skin. Lab Invest. 1998; (4): 497-505
- Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites. Nature. 1998; (6671): 90-3
- The c-kit ligand, stem cell factor, can enhance innate immunity through effects on mast cells. J Exp Med. 1998; (12): 2343-8
- The Paul Kallos Memorial Lecture. The mast cell: a versatile effector cell for a challenging world. Int Arch Allergy Immunol. 1997 May-Jul; (1-3): 14-22
- Absence of Fc epsilonRI alpha chain results in upregulation of Fc gammaRIII-dependent mast cell degranulation and anaphylaxis. Evidence of competition between Fc epsilonRI and Fc gammaRIII for limiting amounts of FcR beta and gamma chains. J Clin Invest. 1997; (5): 915-25
- Complexity and redundancy in the pathogenesis of asthma: reassessing the roles of mast cells and T cells. J Exp Med. 1997; (3): 343-7
- Differential release of mast cell interleukin-6 via c-kit. Blood. 1997; (8): 2654-63
- Expression of functional TrkA receptor tyrosine kinase in the HMC-1 human mast cell line and in human mast cells. Blood. 1997; (5): 1807-20
- IgE enhances mouse mast cell Fc(epsilon)RI expression in vitro and in vivo: evidence for a novel amplification mechanism in IgE-dependent reactions. J Exp Med. 1997; (4): 663-72
- IgE regulates mouse basophil Fc epsilon RI expression in vivo. J Immunol. 1997; (6): 2517-21
- Impaired mast cell-dependent natural immunity in complement C3-deficient mice. Nature. 1997; (6656): 172-5
- Systemic anaphylaxis in the mouse can be mediated largely through IgG1 and Fc gammaRIII. Assessment of the cardiopulmonary changes, mast cell degranulation, and death associated with active or IgE- or IgG1-dependent passive anaphylaxis. J Clin Invest. 1997; (5): 901-14
- Genetic analysis reveals cell type-specific regulation of receptor tyrosine kinase c-Kit by the protein tyrosine phosphatase SHP1. J Exp Med. 1996; (3): 1111-26
- Identification of a committed precursor for the mast cell lineage. Science. 1996; (5250): 818-22
- Recombinant human stem cell factor (kit ligand) promotes human mast cell and melanocyte hyperplasia and functional activation in vivo. J Exp Med. 1996; (6): 2681-6
- The two faces of the mast cell. Nature. 1996; (6577): 21-2
- Dexamethasone or cyclosporin A suppress mast cell-leukocyte cytokine cascades. Multiple mechanisms of inhibition of IgE- and mast cell-dependent cutaneous inflammation in the mouse. J Immunol. 1995; (3): 1391-8
- Stem cell factor contributes to intestinal mucosal mast cell hyperplasia in rats infected with Nippostrongylus brasiliensis or Trichinella spiralis, but anti-stem cell factor treatment decreases parasite egg production during N brasiliensis infection. Blood. 1995; (5): 1968-76
- Cytoplasmic granule formation in mouse pancreatic acinar cells. Evidence for formation of immature granules (condensing vacuoles) by aggregation and fusion of progranules of unit size, and for reductions in membrane surface area and immature granule volume during granule maturation. Cell Tissue Res. 1994; (2): 327-36
- Effects of interleukin-3 with or without the c-kit ligand, stem cell factor, on the survival and cytoplasmic granule formation of mouse basophils and mast cells in vitro. Am J Pathol. 1994; (1): 160-70
- Identification of IgE-bearing cells in the late-phase response to antigen in the lung as basophils. Am J Respir Cell Mol Biol. 1994; (4): 384-90
- Mast cells augment lesion size and persistence during experimental Leishmania major infection in the mouse. J Immunol. 1994; (9): 4563-71
- Piecemeal degranulation of mast cells in the inflammatory eyelid lesions of interleukin-4 transgenic mice. Evidence of mast cell histamine release in vivo by diamine oxidase-gold enzyme-affinity ultrastructural cytochemistry. Blood. 1994; (12): 3600-12
- Promotion of mouse fibroblast collagen gene expression by mast cells stimulated via the Fc epsilon RI. Role for mast cell-derived transforming growth factor beta and tumor necrosis factor alpha. J Exp Med. 1994; (6): 2027-37
- The kit ligand, stem cell factor. Adv Immunol. 1994: 1-96
- Cloning and functional analysis of the mouse c-kit promoter. Biochem Biophys Res Commun. 1993; (3): 893-901
- Distinct patterns of early response gene expression and proliferation in mouse mast cells stimulated by stem cell factor, interleukin-3, or IgE and antigen. Eur J Immunol. 1993; (4): 867-72
- Effects of chronic treatment with the c-kit ligand, stem cell factor, on immunoglobulin E-dependent anaphylaxis in mice. Genetically mast cell-deficient Sl/Sld mice acquire anaphylactic responsiveness, but the congenic normal mice do not exhibit augmented responses. J Clin Invest. 1993; (4): 1639-49
- Human eosinophils can express the cytokines tumor necrosis factor-alpha and macrophage inflammatory protein-1 alpha. J Clin Invest. 1993; (6): 2673-84
- Mast cell activation enhances airway responsiveness to methacholine in the mouse. J Clin Invest. 1993; (3): 1176-82
- Mast cells contribute to the changes in heart rate, but not hypotension or death, associated with active anaphylaxis in mice. J Immunol. 1993; (1): 367-76
- New concepts about the mast cell. N Engl J Med. 1993; (4): 257-65
- Reversible expansion of primate mast cell populations in vivo by stem cell factor. J Clin Invest. 1993; (1): 148-52
- The human recombinant c-kit receptor ligand, rhSCF, induces mediator release from human cutaneous mast cells and enhances IgE-dependent mediator release from both skin mast cells and peripheral blood basophils. J Immunol. 1992; (2): 599-608
- The rat c-kit ligand, stem cell factor, induces c-kit receptor-dependent mouse mast cell activation in vivo. Evidence that signaling through the c-kit receptor can induce expression of cellular function. J Exp Med. 1992; (1): 245-55
- Cytokine production by mast cells and basophils. Curr Opin Immunol. 1991; (6): 865-72
- Differences in the expression of the cardiopulmonary alterations associated with anti-immunoglobulin E-induced or active anaphylaxis in mast cell-deficient and normal mice. Mast cells are not required for the cardiopulmonary changes associated with certain fatal anaphylactic responses. J Clin Invest. 1991; (2): 598-608
- Induction of mast cell proliferation, maturation, and heparin synthesis by the rat c-kit ligand, stem cell factor. Proc Natl Acad Sci U S A. 1991; (14): 6382-6
- Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils. Proc Natl Acad Sci U S A. 1991; (7): 2835-9
- Recruitment of neutrophils during IgE-dependent cutaneous late phase reactions in the mouse is mast cell-dependent. Partial inhibition of the reaction with antiserum against tumor necrosis factor-alpha. J Clin Invest. 1991; (2): 446-53
- Release of both preformed and newly synthesized tumor necrosis factor alpha (TNF-alpha)/cachectin by mouse mast cells stimulated via the Fc epsilon RI. A mechanism for the sustained action of mast cell-derived TNF-alpha during IgE-dependent biological responses. J Exp Med. 1991; (1): 103-7
- Role of mast cells in ion transport abnormalities associated with intestinal anaphylaxis. Correction of the diminished secretory response in genetically mast cell-deficient W/Wv mice by bone marrow transplantation. J Clin Invest. 1991; (2): 687-93
- Stem cell factor (SCF), a novel hematopoietic growth factor and ligand for c-kit tyrosine kinase receptor, maps on human chromosome 12 between 12q14.3 and 12qter. Somat Cell Mol Genet. 1991; (2): 207-14
- The rat c-kit ligand, stem cell factor, induces the development of connective tissue-type and mucosal mast cells in vivo. Analysis by anatomical distribution, histochemistry, and protease phenotype. J Exp Med. 1991; (1): 125-31
- Anatomical variation in mast cell nerve associations in the rat small intestine, heart, lung, and skin. Similarities of distances between neural processes and mast cells, eosinophils, or plasma cells in the jejunal lamina propria. Lab Invest. 1990; (5): 626-34
- Human eosinophils express transforming growth factor alpha. J Exp Med. 1990; (3): 673-81
- Mast cells as a source of both preformed and immunologically inducible TNF-alpha/cachectin. Nature. 1990; (6281): 274-6
- Mast cells as a source of multifunctional cytokines. Immunol Today. 1990; (12): 458-64
- New insights into "the riddle of the mast cells": microenvironmental regulation of mast cell development and phenotypic heterogeneity. Lab Invest. 1990; (1): 5-33
- Phorbol 12-myristate 13-acetate-induced development of functionally active mast cells in W/Wv but not Sl/Sld genetically mast cell-deficient mice. Blood. 1990; (8): 1637-45
- [125I]fibrin deposition occurs at both early and late intervals of IgE-dependent or contact sensitivity reactions elicited in mouse skin. Mast cell-dependent augmentation of fibrin deposition at early intervals in combined IgE-dependent and contact sensitivity reactions. J Immunol. 1990; (11): 3719-27
- Substance P-induced augmentation of cutaneous vascular permeability and granulocyte infiltration in mice is mast cell dependent. J Clin Invest. 1989; (4): 1276-86
Help
Trial Administration