Frederick T. Chin, Ph.D.

Publications

• 18F-Fluorobenzoate-Labeled Cystine Knot Peptides for PET Imaging of Integrin αvβ6. Hackel BJ, Kimura RH, Miao Z, Liu H, Sathirachinda A, Cheng Z, Chin FT, Gambhir SS. J Nucl Med. 2013
• No-carrier-added [18F]fluoroarenes from the radiofluorination of diaryl sulfoxides. Chun JH, Morse CL, Chin FT, Pike VW. Chem Commun (Camb). 2013; 49 (21): 2151-3
• Synthesis of ligand-functionalized water-soluble [18F]YF3 nanoparticles for PET imaging. Xiong L, Shen B, Behera D, Gambhir SS, Chin FT, Rao J. Nanoscale. 2013; 5 (8): 3253-6
• Efficient method for site-specific 18F-labeling of biomolecules using the rapid condensation reaction between 2-cyanobenzothiazole and cysteine. Jeon J, Shen B, Xiong L, Miao Z, Lee KH, Rao J, Chin FT. Bioconjug Chem. 2012; 23 (9): 1902-8
• First experience with clinical-grade ([18F]FPP(RGD₂): an automated multi-step radiosynthesis for clinical PET studies. Chin FT, Shen B, Liu S, Berganos RA, Chang E, Mittra E, Chen X, Gambhir SS. Mol Imaging Biol. 2012; 14 (1): 88-95
• New positron emission tomography (PET) radioligand for imaging σ-1 receptors in living subjects. James ML, Shen B, Zavaleta CL, Nielsen CH, Mesangeau C, Vuppala PK, Chan C, Avery BA, Fishback JA, Matsumoto RR, Gambhir SS, McCurdy CR, Chin FT. J Med Chem. 2012; 55 (19): 8272-82
• 18F-5-fluorouracil dynamic positron emission tomography/computed tomography shows decreased tracer activity after bevacizumab in colorectal metastases. Zissen MH, Kunz P, Subbarayan M, Chin FT, Conti PS, Fisher GA, Quon A. Nucl Med Commun. 2011; 32 (5): 343-7
• Metabolic stability of 6,7-dialkoxy-4-(2-, 3- and 4-[18F]fluoroanilino)quinazolines, potential EGFR imaging probes. Vasdev N, Dorff PN, O'Neil JP, Chin FT, Hanrahan S, VanBrocklin HF. Bioorg Med Chem. 2011; 19 (9): 2959-65
• Molecular Imaging of Hypoxia: Strategies for Probe Design and Application. Apte S, Chin FT, Graves EE. Curr Org Synth. 2011; 8 (4): 593-603
• Pilot pharmacokinetic and dosimetric studies of (18)F-FPPRGD2: a PET radiopharmaceutical agent for imaging α(v)β(3) integrin levels. Mittra ES, Goris ML, Iagaru AH, Kardan A, Burton L, Berganos R, Chang E, Liu S, Shen B, Chin FT, Chen X, Gambhir SS. Radiology. 2011; 260 (1): 182-91
• Recent Progress in Radiofluorination of Peptides for PET Molecular Imaging. Liu S, Shen B, Chin FT, Cheng Z. Curr Org Synth. 2011; 8 (4): 584-592
• Reproducibility study of [(18)F]FPP(RGD)2 uptake in murine models of human tumor xenografts. Chang E, Liu S, Gowrishankar G, Yaghoubi S, Wedgeworth JP, Chin F, Berndorff D, Gekeler V, Gambhir SS, Cheng Z. Eur J Nucl Med Mol Imaging. 2011; 38 (4): 722-30
• 18F-labeled galacto and PEGylated RGD dimers for PET imaging of αvβ3 integrin expression. Liu S, Liu Z, Chen K, Yan Y, Watzlowik P, Wester HJ, Chin FT, Chen X. Mol Imaging Biol. 2010; 12 (5): 530-8
• Dual integrin and gastrin-releasing peptide receptor targeted tumor imaging using 18F-labeled PEGylated RGD-bombesin heterodimer 18F-FB-PEG3-Glu-RGD-BBN. Liu Z, Yan Y, Chin FT, Wang F, Chen X. J Med Chem. 2009; 52 (2): 425-32
• PET of malignant melanoma using 18F-labeled metallopeptides. Ren G, Liu Z, Miao Z, Liu H, Subbarayan M, Chin FT, Zhang L, Gambhir SS, Cheng Z. J Nucl Med. 2009; 50 (11): 1865-72
• Semiautomated radiosynthesis and biological evaluation of [18F]FEAU: a novel PET imaging agent for HSV1-tk/sr39tk reporter gene expression. Chin FT, Namavari M, Levi J, Subbarayan M, Ray P, Chen X, Gambhir SS. Mol Imaging Biol. 2008 Mar-Apr; 10 (2): 82-91
• Initial evaluation of 18F-fluorothymidine (FLT) PET/CT scanning for primary pancreatic cancer. Quon A, Chang ST, Chin F, Kamaya A, Dick DW, Loo BW, Gambhir SS, Koong AC. Eur J Nucl Med Mol Imaging. 2008; 35 (3): 527-31
• Click chemistry for (18)F-labeling of RGD peptides and microPET imaging of tumor integrin alphavbeta3 expression. Li ZB, Wu Z, Chen K, Chin FT, Chen X. Bioconjug Chem. 2007 Nov-Dec; 18 (6): 1987-94
• 18F-labeled mini-PEG spacered RGD dimer (18F-FPRGD2): synthesis and microPET imaging of alphavbeta3 integrin expression. Wu Z, Li ZB, Cai W, He L, Chin FT, Li F, Chen X. Eur J Nucl Med Mol Imaging. 2007; 34 (11): 1823-31
• Human biodistribution and radiation dosimetry of the tachykinin NK1 antagonist radioligand [18F]SPA-RQ: comparison of thin-slice, bisected, and 2-dimensional planar image analysis. Sprague DR, Chin FT, Liow JS, Fujita M, Burns HD, Hargreaves R, Stubbs JB, Pike VW, Innis RB, Mozley PD. J Nucl Med. 2007; 48 (1): 100-7
• PET imaging of neurokinin-1 receptors with [(18)F]SPA-RQ in human subjects: assessment of reference tissue models and their test-retest reproducibility. Yasuno F, Sanabria SM, Burns D, Hargreaves RJ, Ghose S, Ichise M, Chin FT, Morse CL, Pike VW, Innis RB. Synapse. 2007; 61 (4): 242-51
• Persistent dopamine functions of neurons derived from embryonic stem cells in a rodent model of Parkinson disease. Rodríguez-Gómez JA, Lu JQ, Velasco I, Rivera S, Zoghbi SS, Liow JS, Musachio JL, Chin FT, Toyama H, Seidel J, Green MV, Thanos PK, Ichise M, Pike VW, Innis RB, McKay RD. Stem Cells. 2007; 25 (4): 918-28
• microPET of tumor integrin alphavbeta3 expression using 18F-labeled PEGylated tetrameric RGD peptide (18F-FPRGD4). Wu Z, Li ZB, Chen K, Cai W, He L, Chin FT, Li F, Chen X. J Nucl Med. 2007; 48 (9): 1536-44
• Automated radiosynthesis of [18F]SPA-RQ for imaging human brain NK1 receptors with PET Chin FT, Morse CL, Pike VW.. Journal of Labelled Compounds and Radiopharmaceuticals. 2006; 49 (1): 17-31
• Alternative methods for labeling the 5-HT1A receptor agonist, 1-[2-(4-fluorobenzoylamino)ethyl]-4-(7-methoxynaphthyl)piperazine (S14506), with carbon-11 or fluorine-18 Lu SY, Hong J, Musachio JL, Chin FT, Vermeulen ES, Wikström HV, Pike VW. Journal of Labelled Compounds and Radiopharmaceuticals. 2005; 48 (13): 971-981
• Use of LC-MS-MS for the rapid, specific and sensitive quality control measurement of carrier in a PET radioligand: [18F]FECNT Shetty HU, Chin FT, Musachio JL, Pike VW. Journal of Labelled Compounds and Radiopharmaceuticals. 2005; 48 (13): 929-940
• Efficient O- and N-(-fluoroethylation)s with NCA [18F]-fluoroethyl tosylate under microwave-enhanced conditions Lu SY, Chin FT, McCarron JA, Pike VW. Journal of Labelled Compounds and Radiopharmaceuticals. 2004; 47 (5): 289-297
• Syntheses of 11C- and 18F-labeled carboxylic esters within a hydrodynamically-driven micro-reactor. Lu SY, Watts P, Chin FT, Hong J, Musachio JL, Briard E, Pike VW. Lab Chip. 2004; 4 (6): 523-5
• Synthesis and evaluation of two 18F-labeled 6-iodo-2-(4'-N,N-dimethylamino)phenylimidazo[1,2-a]pyridine derivatives as prospective radioligands for beta-amyloid in Alzheimer's disease. Cai L, Chin FT, Pike VW, Toyama H, Liow JS, Zoghbi SS, Modell K, Briard E, Shetty HU, Sinclair K, Donohue S, Tipre D, Kung MP, Dagostin C, Widdowson DA, Green M, Gao W, Herman MM, Ichise M, Innis RB. J Med Chem. 2004; 47 (9): 2208-18
• Whole-body biodistribution and radiation dosimetry estimates for the PET dopamine transporter probe 18F-FECNT in non-human primates. Tipre DN, Fujita M, Chin FT, Seneca N, Vines D, Liow JS, Pike VW, Innis RB. Nucl Med Commun. 2004; 25 (7): 737-42
• Mouse and Rat Imaging and Quantitative Analysis with Small Animal PET Toyama H, Ichise M, Liow J-S, Vines D, Chin F, Pike V, Esaki T, Shimoji T, Seidel J, Green M, Innis RB, Katada K. Medical Imaging and Information. 2003; 31 (12): 946-951