Jorg Goronzy
Publications
- IL-7- and IL-15-mediated TCR sensitization enables T cell responses to self-antigens. J Immunol. 2013; (4): 1416-23
- Understanding immunosenescence to improve responses to vaccines. Nat Immunol. 2013; (5): 428-36
- CD8+CD45RA+CCR7+FOXP3+ T cells with immunosuppressive properties: a novel subset of inducible human regulatory T cells. J Immunol. 2012; (5): 2118-30
- Chronic inflammation and aging: DNA damage tips the balance. Curr Opin Immunol. 2012; (4): 488-93
- Decline in miR-181a expression with age impairs T cell receptor sensitivity by increasing DUSP6 activity. Nat Med. 2012; (10): 1518-24
- Immune aging and autoimmunity. Cell Mol Life Sci. 2012; (10): 1615-23
- Mechanisms of immunosenescence: lessons from models of accelerated immune aging. Ann N Y Acad Sci. 2012: 69-82
- Signal inhibition by the dual-specific phosphatase 4 impairs T cell-dependent B-cell responses with age. Proc Natl Acad Sci U S A. 2012; (15): E879-88
- Signaling pathways in aged T cells - a reflection of T cell differentiation, cell senescence and host environment. Semin Immunol. 2012; (5): 365-72
- The immunopathology of giant cell arteritis: diagnostic and therapeutic implications. J Neuroophthalmol. 2012; (3): 259-65
- Blocking the NOTCH pathway inhibits vascular inflammation in large-vessel vasculitis. Circulation. 2011; (3): 309-18
- Finding Balance: T cell Regulatory Receptor Expression during Aging. Aging Dis. 2011; (5): 398-413
- Giant cell arteritis: immune and vascular aging as disease risk factors. Arthritis Res Ther. 2011; (4): 231
- IFN-γ and IL-17: the two faces of T-cell pathology in giant cell arteritis. Curr Opin Rheumatol. 2011; (1): 43-9
- Magnetic resonance angiography in extracranial giant cell arteritis. J Clin Rheumatol. 2011; (6): 306-10
- Regulation of T cell receptor signaling by activation-induced zinc influx. J Exp Med. 2011; (4): 775-85
- Report from the second cytomegalovirus and immunosenescence workshop. Immun Ageing. 2011; (1): 10
- Role of increased guanosine triphosphate cyclohydrolase-1 expression and tetrahydrobiopterin levels upon T cell activation. J Biol Chem. 2011; (16): 13846-51
- Telomere dysfunction, autoimmunity and aging. Aging Dis. 2011; (6): 524-37
- DNA-dependent protein kinase catalytic subunit mediates T-cell loss in rheumatoid arthritis. EMBO Mol Med. 2010; (10): 415-27
- Immune aging and rheumatoid arthritis. Rheum Dis Clin North Am. 2010; (2): 297-310
- Immune senescence. Curr Opin Immunol. 2010; (4): 497-9
- Inhibition and genetic ablation of the B7/CD28 T-cell costimulation axis prevents experimental hypertension. Circulation. 2010; (24): 2529-37
- Insufficient deactivation of the protein tyrosine kinase lck amplifies T-cell responsiveness in acute coronary syndrome. Circ Res. 2010; (4): 769-78
- Promoter choice and translational repression determine cell type-specific cell surface density of the inhibitory receptor CD85j expressed on different hematopoietic lineages. Blood. 2010; (16): 3278-86
- Telomeres and immunological diseases of aging. Gerontology. 2010; (4): 390-403
- Th17 and Th1 T-cell responses in giant cell arteritis. Circulation. 2010; (7): 906-15
- Altered naive and memory CD4+ T-cell homeostasis and immunosenescence characterize younger patients with myelodysplastic syndrome. Leukemia. 2009; (7): 1288-96
- CD28(-) T cells: their role in the age-associated decline of immune function. Trends Immunol. 2009; (7): 306-12
- Deficiency of the DNA repair enzyme ATM in rheumatoid arthritis. J Exp Med. 2009; (6): 1435-49
- Developments in the scientific understanding of rheumatoid arthritis. Arthritis Res Ther. 2009; (5): 249
- ERK-dependent T cell receptor threshold calibration in rheumatoid arthritis. J Immunol. 2009; (12): 8258-67
- Epigenetic regulation of killer immunoglobulin-like receptor expression in T cells. Blood. 2009; (16): 3422-30
- Rejuvenating the immune system in rheumatoid arthritis. Nat Rev Rheumatol. 2009; (10): 583-8
- Telomerase insufficiency in rheumatoid arthritis. Proc Natl Acad Sci U S A. 2009; (11): 4360-5
- Toll-like receptors 4 and 5 induce distinct types of vasculitis. Circ Res. 2009; (4): 488-95
- Treating autoimmune disease by targeting CD8(+) T suppressor cells. Expert Opin Biol Ther. 2009; (8): 951-65
- Vascular damage in giant cell arteritis. Autoimmunity. 2009; (7): 596-604
- [Pathogenesis of medium- and large-vessel vasculitis]. Z Rheumatol. 2009; (2): 100-7
- Age-dependent signature of metallothionein expression in primary CD4 T cell responses is due to sustained zinc signaling. Rejuvenation Res. 2008; (6): 1001-11
- Defective proliferative capacity and accelerated telomeric loss of hematopoietic progenitor cells in rheumatoid arthritis. Arthritis Rheum. 2008; (4): 990-1000
- Epigenetic mechanisms of age-dependent KIR2DL4 expression in T cells. J Leukoc Biol. 2008; (3): 824-34
- Inhibitory CD8+ T cells in autoimmune disease. Hum Immunol. 2008; (11): 781-9
- Is hypertension an immunologic disease? Curr Cardiol Rep. 2008; (6): 464-9
- Synoviocyte stimulation by the LFA-1-intercellular adhesion molecule-2-Ezrin-Akt pathway in rheumatoid arthritis. J Immunol. 2008; (3): 1971-8
- T cell subset-specific susceptibility to aging. Clin Immunol. 2008; (1): 107-18
- T cells in arteritis and atherosclerosis. Curr Opin Lipidol. 2008; (5): 469-77
- T-cell co-stimulatory pathways in autoimmunity. Arthritis Res Ther. 2008: S3
- TLR-mediated induction of negative regulatory ligands on dendritic cells. J Mol Med (Berl). 2008; (4): 443-55
- Vessel wall-embedded dendritic cells induce T-cell autoreactivity and initiate vascular inflammation. Circ Res. 2008; (5): 546-53
- Vessel-specific Toll-like receptor profiles in human medium and large arteries. Circulation. 2008; (12): 1276-84
- Aging and T-cell diversity. Exp Gerontol. 2007; (5): 400-6
- Fractalkine mediates T cell-dependent proliferation of synovial fibroblasts in rheumatoid arthritis. Arthritis Rheum. 2007; (10): 3215-25
- Functional profile of activated dendritic cells in unstable atherosclerotic plaque. Basic Res Cardiol. 2007; (2): 123-32
- Immune-mediated mechanisms in atherosclerosis: prevention and treatment of clinical manifestations. Curr Pharm Des. 2007; (36): 3701-10
- Occurrence of giant cell arteritis...suddenly. Trans Am Ophthalmol Soc. 2007: 141-4; discussion 144-5
- Role of the T cell in the genesis of angiotensin II induced hypertension and vascular dysfunction. J Exp Med. 2007; (10): 2449-60
- Synergistic proinflammatory effects of the antiviral cytokine interferon-alpha and Toll-like receptor 4 ligands in the atherosclerotic plaque. Circulation. 2007; (18): 2043-52
- Unchecked CD70 expression on T cells lowers threshold for T cell activation in rheumatoid arthritis. J Immunol. 2007; (4): 2609-15
- Association of HLA-C3 and smoking with vasculitis in patients with rheumatoid arthritis. Arthritis Rheum. 2006; (9): 2776-83
- Immunosuppression in atherosclerosis: mobilizing the opposition within. Circulation. 2006; (18): 1901-4
- Interleukin 12 induces T-cell recruitment into the atherosclerotic plaque. Circ Res. 2006; (4): 524-31
- Lymphoma in rheumatoid arthritis: an immune system set up for failure. Arthritis Rheum. 2006; (3): 685-9
- Pathogen-sensing plasmacytoid dendritic cells stimulate cytotoxic T-cell function in the atherosclerotic plaque through interferon-alpha. Circulation. 2006; (23): 2482-9
- Pathomechanisms in rheumatoid arthritis--time for a string theory? J Clin Invest. 2006; (4): 869-71
- Simvastatin suppresses endotoxin-induced upregulation of toll-like receptors 4 and 2 in vivo. Atherosclerosis. 2006; (2): 408-13
- T cell recognition and killing of vascular smooth muscle cells in acute coronary syndrome. Circ Res. 2006; (9): 1168-76
- T-cell-targeted therapies in rheumatoid arthritis. Nat Clin Pract Rheumatol. 2006; (4): 201-10
- TRAIL-expressing T cells induce apoptosis of vascular smooth muscle cells in the atherosclerotic plaque. J Exp Med. 2006; (1): 239-50
- Telomeres, immune aging and autoimmunity. Exp Gerontol. 2006; (3): 246-51
- Treatment of chronic inflammatory diseases with biologic agents: opportunities and risks for the elderly. Exp Gerontol. 2006; (12): 1250-5
- Treatment of giant cell arteritis using induction therapy with high-dose glucocorticoids: a double-blind, placebo-controlled, randomized prospective clinical trial. Arthritis Rheum. 2006; (10): 3310-8
- Uncoupling of T-cell effector functions by inhibitory killer immunoglobulin-like receptors. Blood. 2006; (11): 4449-57
- B cells as a therapeutic target in autoimmune diseases. Expert Opin Ther Targets. 2005; (3): 431-45
- B cells in rheumatoid synovitis. Arthritis Res Ther. 2005: S9-12
- BLyS and APRIL in rheumatoid arthritis. J Clin Invest. 2005; (11): 3083-92
- Cell-based immunotherapy with suppressor CD8+ T cells in rheumatoid arthritis. J Immunol. 2005; (11): 7292-301
- Costimulatory pathways in rheumatoid synovitis and T-cell senescence. Ann N Y Acad Sci. 2005: 182-94
- Distinct transcriptional control mechanisms of killer immunoglobulin-like receptors in natural killer (NK) and in T cells. J Biol Chem. 2005; (25): 24277-85
- Lipopolysaccharide, CD14 and Toll-like receptors: an emerging link between innate immunity and atherosclerotic disease. Future Cardiol. 2005; (5): 657-74
- Modulation of CD28 expression with anti-tumor necrosis factor alpha therapy in rheumatoid arthritis. Arthritis Rheum. 2005; (10): 2996-3003
- Rheumatoid arthritis is an independent risk factor for multi-vessel coronary artery disease: a case control study. Arthritis Res Ther. 2005; (5): R984-91
- Rheumatoid arthritis. Immunol Rev. 2005: 55-73
- T cell costimulation by fractalkine-expressing synoviocytes in rheumatoid arthritis. Arthritis Rheum. 2005; (5): 1392-401
- T cell development and receptor diversity during aging. Curr Opin Immunol. 2005; (5): 468-75
- The impact of HLA-DRB1 genes on extra-articular disease manifestations in rheumatoid arthritis. Arthritis Res Ther. 2005; (6): R1386-93
- The influence of age on T cell generation and TCR diversity. J Immunol. 2005; (11): 7446-52
- Tissue trafficking patterns of effector memory CD4+ T cells in rheumatoid arthritis. Arthritis Rheum. 2005; (12): 3839-49
- Toll-like receptors in giant cell arteritis. Clin Immunol. 2005; (1): 38-46
- Vascular dendritic cells in giant cell arteritis. Ann N Y Acad Sci. 2005: 195-208
- Activation of arterial wall dendritic cells and breakdown of self-tolerance in giant cell arteritis. J Exp Med. 2004; (2): 173-83
- Biology of T lymphocytes. Rheum Dis Clin North Am. 2004; (1): 135-57
- HLA-DRB1 haplotype did not affect the medium-term results of total knee arthroplasty in patients with rheumatoid arthritis. Mod Rheumatol. 2004; (1): 37-42
- How aggressive should initial therapy for rheumatoid arthritis be? Factors associated with response to 'non-aggressive' DMARD treatment and perspective from a 2-yr open label trial. Rheumatology (Oxford). 2004; (5): 619-25
- Immunopathways in giant cell arteritis and polymyalgia rheumatica. Autoimmun Rev. 2004; (1): 46-53
- Lymphotoxin beta-mediated stimulation of synoviocytes in rheumatoid arthritis. Arthritis Rheum. 2004; (7): 2140-50
- Prognostic markers of radiographic progression in early rheumatoid arthritis. Arthritis Rheum. 2004; (1): 43-54
- Stem cell aging and autoimmunity in rheumatoid arthritis. Trends Mol Med. 2004; (9): 426-33
- Stimulatory killer Ig-like receptors modulate T cell activation through DAP12-dependent and DAP12-independent mechanisms. J Immunol. 2004; (6): 3725-31
- T-cell regulation in rheumatoid arthritis. Curr Opin Rheumatol. 2004; (3): 212-7
- T-cell senescence: a culprit of immune abnormalities in chronic inflammation and persistent infection. Trends Mol Med. 2004; (3): 119-24
- The double life of NK receptors: stimulation or co-stimulation? Trends Immunol. 2004; (1): 25-32
- Thrombospondin 2 functions as an endogenous regulator of angiogenesis and inflammation in rheumatoid arthritis. Am J Pathol. 2004; (6): 2087-98
- Tumor necrosis factor-alpha and CD80 modulate CD28 expression through a similar mechanism of T-cell receptor-independent inhibition of transcription. J Biol Chem. 2004; (28): 29130-8
- VEGF gene polymorphisms and susceptibility to rheumatoid arthritis. Rheumatology (Oxford). 2004; (9): 1173-7
- Aging, autoimmunity and arthritis: T-cell senescence and contraction of T-cell repertoire diversity - catalysts of autoimmunity and chronic inflammation. Arthritis Res Ther. 2003; (5): 225-34
- B cells as a therapeutic target in autoimmune disease. Arthritis Res Ther. 2003; (3): 131-5
- CD28 loss in senescent CD4+ T cells: reversal by interleukin-12 stimulation. Blood. 2003; (9): 3543-9
- De novo expression of killer immunoglobulin-like receptors and signaling proteins regulates the cytotoxic function of CD4 T cells in acute coronary syndromes. Circ Res. 2003; (2): 106-13
- Ectopic germinal center formation in rheumatoid synovitis. Ann N Y Acad Sci. 2003: 140-9
- Giant-cell arteritis and polymyalgia rheumatica. Ann Intern Med. 2003; (6): 505-15
- Homeostatic control of T-cell generation in neonates. Blood. 2003; (4): 1428-34
- Immunosenescence, autoimmunity, and rheumatoid arthritis. Exp Gerontol. 2003; (8): 833-41
- Medium- and large-vessel vasculitis. N Engl J Med. 2003; (2): 160-9
- Premature telomeric loss in rheumatoid arthritis is genetically determined and involves both myeloid and lymphoid cell lineages. Proc Natl Acad Sci U S A. 2003; (23): 13471-6
- Selective activation of the c-Jun NH2-terminal protein kinase signaling pathway by stimulatory KIR in the absence of KARAP/DAP12 in CD4+ T cells. J Exp Med. 2003; (4): 437-49
- Synoviocyte-mediated expansion of inflammatory T cells in rheumatoid synovitis is dependent on CD47-thrombospondin 1 interaction. J Immunol. 2003; (4): 1732-40
- The power of the third dimension: tissue architecture and autoimmunity in rheumatoid arthritis. Curr Opin Rheumatol. 2003; (3): 259-66
- Bi-directional modulation of T cell-dependent antibody production by prostaglandin E(2). Int Immunol. 2002; (1): 69-77
- CD8 T cells are required for the formation of ectopic germinal centers in rheumatoid synovitis. J Exp Med. 2002; (10): 1325-36
- Cytokines in giant-cell arteritis. Cleve Clin J Med. 2002: SII91-4
- Formation of the killer Ig-like receptor repertoire on CD4+CD28null T cells. J Immunol. 2002; (8): 3839-46
- Molecular basis for the loss of CD28 expression in senescent T cells. J Biol Chem. 2002; (49): 46940-9
- Pathogenic mechanisms in giant cell arteritis. Cleve Clin J Med. 2002: SII28-32
- Premature immunosenescence in rheumatoid arthritis. J Rheumatol. 2002; (6): 1141-6
- Reactive nitrogen intermediates in giant cell arteritis: selective nitration of neocapillaries. Am J Pathol. 2002; (1): 115-23
- T-cell-mediated lysis of endothelial cells in acute coronary syndromes. Circulation. 2002; (5): 570-5
- Therapeutic effects of acetylsalicylic acid in giant cell arteritis. Arthritis Rheum. 2002; (2): 457-66
- Trapping of misdirected dendritic cells in the granulomatous lesions of giant cell arteritis. Am J Pathol. 2002; (5): 1815-23
- CD4+,CD28- T cells in rheumatoid arthritis patients combine features of the innate and adaptive immune systems. Arthritis Rheum. 2001; (1): 13-20
- Down-regulation of CD28 expression by TNF-alpha. J Immunol. 2001; (6): 3231-8
- Ectopic lymphoid organogenesis: a fast track for autoimmunity. Am J Pathol. 2001; (3): 787-93
- Functional disruption of the CD28 gene transcriptional initiator in senescent T cells. J Biol Chem. 2001; (4): 2565-70
- Lymphoid microstructures in rheumatoid synovitis. Curr Dir Autoimmun. 2001: 168-87
- Lymphoid neogenesis in rheumatoid synovitis. J Immunol. 2001; (2): 1072-80
- Major histocompatibility complex class I-recognizing receptors are disease risk genes in rheumatoid arthritis. J Exp Med. 2001; (10): 1159-67
- Molecular fingerprint of interferon-gamma signaling in unstable angina. Circulation. 2001; (11): 1509-14
- T cell activation in rheumatoid synovium is B cell dependent. J Immunol. 2001; (8): 4710-8
- T cell homeostasis and autoreactivity in rheumatoid arthritis. Curr Dir Autoimmun. 2001: 112-32
- T-cell immunity in acute coronary syndromes. Mayo Clin Proc. 2001; (10): 1011-20
- Thymic function and peripheral T-cell homeostasis in rheumatoid arthritis. Trends Immunol. 2001; (5): 251-5
- Value of immunological markers in predicting responsiveness to influenza vaccination in elderly individuals. J Virol. 2001; (24): 12182-7
- Association of MHC and rheumatoid arthritis. HLA polymorphisms in phenotypic variants of rheumatoid arthritis. Arthritis Res. 2000; (3): 212-6
- Cell-cell interactions in synovitis. Interactions between T cells and B cells in rheumatoid arthritis. Arthritis Res. 2000; (6): 457-63
- Central role of thrombospondin-1 in the activation and clonal expansion of inflammatory T cells. J Immunol. 2000; (6): 2947-54
- Clonality and longevity of CD4+CD28null T cells are associated with defects in apoptotic pathways. J Immunol. 2000; (11): 6301-7
- Killer cell activating receptors function as costimulatory molecules on CD4+CD28null T cells clonally expanded in rheumatoid arthritis. J Immunol. 2000; (2): 1138-45
- Monoclonal T-cell proliferation and plaque instability in acute coronary syndromes. Circulation. 2000; (25): 2883-8
- Pathogenic principles in giant cell arteritis. Int J Cardiol. 2000: S9-S15; discussion S17-9
- T cell homeostasis in patients with rheumatoid arthritis. Proc Natl Acad Sci U S A. 2000; (16): 9203-8
- The role of T cells in rheumatoid arthritis. Arch Immunol Ther Exp (Warsz). 2000; (5): 429-35
- Treatment of giant cell arteritis: interleukin-6 as a biologic marker of disease activity. Arthritis Rheum. 2000; (5): 1041-8
- [Clinical and genetic heterogeneity of rheumatoid arthritis]. Postepy Hig Med Dosw. 2000; (6): 845-53
- Aberrations in the primary T-cell receptor repertoire as a predisposition for synovial inflammation in rheumatoid arthritis. J Investig Med. 1999; (5): 236-45
- Formation of new vasa vasorum in vasculitis. Production of angiogenic cytokines by multinucleated giant cells. Am J Pathol. 1999; (3): 765-74
- HLA polymorphisms and T cells in rheumatoid arthritis. Int Rev Immunol. 1999; (1-2): 37-59
- Modulation of CD28 expression: distinct regulatory pathways during activation and replicative senescence. J Immunol. 1999; (11): 6572-9
- Perturbation of the T-cell repertoire in patients with unstable angina. Circulation. 1999; (21): 2135-9
- T-cell responses in rheumatoid arthritis: systemic abnormalities-local disease. Curr Opin Rheumatol. 1999; (3): 210-7
- Tissue-destructive macrophages in giant cell arteritis. Circ Res. 1999; (9): 1050-8
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