Marius Wernig

Publications

• Direct conversion of mouse fibroblasts to self-renewing, tripotent neural precursor cells. Lujan E, Chanda S, Ahlenius H, Südhof TC, Wernig M. Proc Natl Acad Sci U S A. 2012; 109 (7): 2527-32
• Direct lineage conversion of terminally differentiated hepatocytes to functional neurons. Marro S, Pang ZP, Yang N, Tsai MC, Qu K, Chang HY, Südhof TC, Wernig M. Cell Stem Cell. 2011; 9 (4): 374-82
• In situ genetic correction of the sickle cell anemia mutation in human induced pluripotent stem cells using engineered zinc finger nucleases. Sebastiano V, Maeder ML, Angstman JF, Haddad B, Khayter C, Yeo DT, Goodwin MJ, Hawkins JS, Ramirez CL, Batista LF, Artandi SE, Wernig M, Joung JK. Stem Cells. 2011; 29 (11): 1717-26
• Induction of human neuronal cells by defined transcription factors. Pang ZP, Yang N, Vierbuchen T, Ostermeier A, Fuentes DR, Yang TQ, Citri A, Sebastiano V, Marro S, Südhof TC, Wernig M. Nature. 2011; 476 (7359): 220-3
• Direct conversion of fibroblasts to functional neurons by defined factors. Vierbuchen T, Ostermeier A, Pang ZP, Kokubu Y, Südhof TC, Wernig M. Nature. 2010; 463 (7284): 1035-41
• Acute reduction in oxygen tension enhances the induction of neurons from human fibroblasts. Davila J, Chanda S, Ang CE, Südhof TC, Wernig M. J Neurosci Methods. 2013
• An indirect approach to generating specific human cell types. Lujan E, Wernig M. Nat Methods. 2013; 10 (1): 44-5
• Comprehensive qPCR profiling of gene expression in single neuronal cells. Citri A, Pang ZP, Südhof TC, Wernig M, Malenka RC. Nat Protoc. 2012; 7 (1): 118-27
• Molecular roadblocks for cellular reprogramming. Vierbuchen T, Wernig M. Mol Cell. 2012; 47 (6): 827-38
• The many roads to Rome: induction of neural precursor cells from fibroblasts. Lujan E, Wernig M. Curr Opin Genet Dev. 2012; 22 (5): 517-22
• Cellular reprogramming: recent advances in modeling neurological diseases. Ming GL, Brüstle O, Muotri A, Studer L, Wernig M, Christian KM. J Neurosci. 2011; 31 (45): 16070-5
• Direct lineage conversions: unnatural but useful? Vierbuchen T, Wernig M. Nat Biotechnol. 2011; 29 (10): 892-907
• Induced neuronal cells: how to make and define a neuron. Yang N, Ng YH, Pang ZP, Südhof TC, Wernig M. Cell Stem Cell. 2011; 9 (6): 517-25
• Telomere shortening and loss of self-renewal in dyskeratosis congenita induced pluripotent stem cells. Batista LF, Pech MF, Zhong FL, Nguyen HN, Xie KT, Zaug AJ, Crary SM, Choi J, Sebastiano V, Cherry A, Giri N, Wernig M, Alter BP, Cech TR, Savage SA, Reijo Pera RA, Artandi SE. Nature. 2011; 474 (7351): 399-402
• An imprinted signature helps isolate ESC-equivalent iPSCs. Lujan E, Wernig M. Cell Res. 2010; 20 (9): 974-6
• Comparison of contractile behavior of native murine ventricular tissue and cardiomyocytes derived from embryonic or induced pluripotent stem cells. Xi J, Khalil M, Shishechian N, Hannes T, Pfannkuche K, Liang H, Fatima A, Haustein M, Suhr F, Bloch W, Reppel M, Sarić T, Wernig M, Jänisch R, Brockmeier K, Hescheler J, Pillekamp F. FASEB J. 2010; 24 (8): 2739-51
• Cardiac myocytes derived from murine reprogrammed fibroblasts: intact hormonal regulation, cardiac ion channel expression and development of contractility. Pfannkuche K, Liang H, Hannes T, Xi J, Fatima A, Nguemo F, Matzkies M, Wernig M, Jaenisch R, Pillekamp F, Halbach M, Schunkert H, Sarić T, Hescheler J, Reppel M. Cell Physiol Biochem. 2009; 24 (1-2): 73-86
• Functional characterization of cardiomyocytes derived from murine induced pluripotent stem cells in vitro. Kuzmenkin A, Liang H, Xu G, Pfannkuche K, Eichhorn H, Fatima A, Luo H, Saric T, Wernig M, Jaenisch R, Hescheler J. FASEB J. 2009; 23 (12): 4168-80
• A drug-inducible transgenic system for direct reprogramming of multiple somatic cell types. Wernig M, Lengner CJ, Hanna J, Lodato MA, Steine E, Foreman R, Staerk J, Markoulaki S, Jaenisch R. Nat Biotechnol. 2008; 26 (8): 916-24
• Connecting microRNA genes to the core transcriptional regulatory circuitry of embryonic stem cells. Marson A, Levine SS, Cole MF, Frampton GM, Brambrink T, Johnstone S, Guenther MG, Johnston WK, Wernig M, Newman J, Calabrese JM, Dennis LM, Volkert TL, Gupta S, Love J, Hannett N, Sharp PA, Bartel DP, Jaenisch R, Young RA. Cell. 2008; 134 (3): 521-33
• Direct reprogramming of terminally differentiated mature B lymphocytes to pluripotency. Hanna J, Markoulaki S, Schorderet P, Carey BW, Beard C, Wernig M, Creyghton MP, Steine EJ, Cassady JP, Foreman R, Lengner CJ, Dausman JA, Jaenisch R. Cell. 2008; 133 (2): 250-64
• Dissecting direct reprogramming through integrative genomic analysis. Mikkelsen TS, Hanna J, Zhang X, Ku M, Wernig M, Schorderet P, Bernstein BE, Jaenisch R, Lander ES, Meissner A. Nature. 2008; 454 (7200): 49-55
• Genome-scale DNA methylation maps of pluripotent and differentiated cells. Meissner A, Mikkelsen TS, Gu H, Wernig M, Hanna J, Sivachenko A, Zhang X, Bernstein BE, Nusbaum C, Jaffe DB, Gnirke A, Jaenisch R, Lander ES. Nature. 2008; 454 (7205): 766-70
• Neurons derived from reprogrammed fibroblasts functionally integrate into the fetal brain and improve symptoms of rats with Parkinson's disease. Wernig M, Zhao JP, Pruszak J, Hedlund E, Fu D, Soldner F, Broccoli V, Constantine-Paton M, Isacson O, Jaenisch R. Proc Natl Acad Sci U S A. 2008; 105 (15): 5856-61
• Sequential expression of pluripotency markers during direct reprogramming of mouse somatic cells. Brambrink T, Foreman R, Welstead GG, Lengner CJ, Wernig M, Suh H, Jaenisch R. Cell Stem Cell. 2008; 2 (2): 151-9
• c-Myc is dispensable for direct reprogramming of mouse fibroblasts. Wernig M, Meissner A, Cassady JP, Jaenisch R. Cell Stem Cell. 2008; 2 (1): 10-2
• Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells. Meissner A, Wernig M, Jaenisch R. Nat Biotechnol. 2007; 25 (10): 1177-81
• Genome-wide maps of chromatin state in pluripotent and lineage-committed cells. Mikkelsen TS, Ku M, Jaffe DB, Issac B, Lieberman E, Giannoukos G, Alvarez P, Brockman W, Kim TK, Koche RP, Lee W, Mendenhall E, O'Donovan A, Presser A, Russ C, Xie X, Meissner A, Wernig M, Jaenisch R, Nusbaum C, Lander ES, Bernstein BE. Nature. 2007; 448 (7153): 553-60
• In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state. Wernig M, Meissner A, Foreman R, Brambrink T, Ku M, Hochedlinger K, Bernstein BE, Jaenisch R. Nature. 2007; 448 (7151): 318-24
• Treatment of sickle cell anemia mouse model with iPS cells generated from autologous skin. Hanna J, Wernig M, Markoulaki S, Sun CW, Meissner A, Cassady JP, Beard C, Brambrink T, Wu LC, Townes TM, Jaenisch R. Science. 2007; 318 (5858): 1920-3
• A bivalent chromatin structure marks key developmental genes in embryonic stem cells. Bernstein BE, Mikkelsen TS, Xie X, Kamal M, Huebert DJ, Cuff J, Fry B, Meissner A, Wernig M, Plath K, Jaenisch R, Wagschal A, Feil R, Schreiber SL, Lander ES. Cell. 2006; 125 (2): 315-26
• Polycomb complexes repress developmental regulators in murine embryonic stem cells. Boyer LA, Plath K, Zeitlinger J, Brambrink T, Medeiros LA, Lee TI, Levine SS, Wernig M, Tajonar A, Ray MK, Bell GW, Otte AP, Vidal M, Gifford DK, Young RA, Jaenisch R. Nature. 2006; 441 (7091): 349-53
• The vast majority of bone-marrow-derived cells integrated into mdx muscle fibers are silent despite long-term engraftment. Wernig G, Janzen V, Schäfer R, Zweyer M, Knauf U, Hoegemeier O, Mundegar RR, Garbe S, Stier S, Franz T, Wernig M, Wernig A. Proc Natl Acad Sci U S A. 2005; 102 (33): 11852-7
• Functional integration of embryonic stem cell-derived neurons in vivo. Wernig M, Benninger F, Schmandt T, Rade M, Tucker KL, Büssow H, Beck H, Brüstle O. J Neurosci. 2004; 24 (22): 5258-68
• Functional integration of embryonic stem cell-derived neurons in hippocampal slice cultures. Benninger F, Beck H, Wernig M, Tucker KL, Brüstle O, Scheffler B. J Neurosci. 2003; 23 (18): 7075-83
• Migration and differentiation of myogenic precursors following transplantation into the developing rat brain. Steffel J, Wernig M, Knauf U, Kumar S, Wiestler OD, Wernig A, Brüstle O. Stem Cells. 2003; 21 (2): 181-9
• Fifty ways to make a neuron: shifts in stem cell hierarchy and their implications for neuropathology and CNS repair. Wernig M, Brüstle O. J Neuropathol Exp Neurol. 2002; 61 (2): 101-10
• Tau EGFP embryonic stem cells: an efficient tool for neuronal lineage selection and transplantation. Wernig M, Tucker KL, Gornik V, Schneiders A, Buschwald R, Wiestler OD, Barde YA, Brüstle O. J Neurosci Res. 2002; 69 (6): 918-24
• In vitro differentiation of transplantable neural precursors from human embryonic stem cells. Zhang SC, Wernig M, Duncan ID, Brüstle O, Thomson JA. Nat Biotechnol. 2001; 19 (12): 1129-33
• A mouse model for valproate teratogenicity: parental effects, homeotic transformations, and altered HOX expression. Faiella A, Wernig M, Consalez GG, Hostick U, Hofmann C, Hustert E, Boncinelli E, Balling R, Nadeau JH. Hum Mol Genet. 2000; 9 (2): 227-36