Department: Cancer Center

Division: Cancer Immunology

• Faculty (15)
• Postdocs (0)
• All

• 
  Bloch, Daniel 
  Academic Appointments

  • Member, Cancer Center
• 
  Butcher, Eugene 
  Academic Appointments

  • Professor, Pathology
  • Member, Cancer Center
  Research Interest

  Our interests include: 1) The physiology and significance of lymphocyte homing in local and systemic immunity; 2) biochemical and genetic studies of molecules that direct leukocyte recruitment; 3) cellular and molecular genetic studies of leukocyte chemotaxis and the role of chemokines; 4) vascular differentiation in normal and pathologic inflammatory states; 5) systems and chemical biology approaches to understanding the regulation of lymphocyte trafficking programs.

• 
  Chien, Yueh-Hsiu 
  Academic Appointments

  • Professor, Microbiology & Immunology
  • Member, Cancer Center
  Research Interest

  Contribution of T cells to immunocompetence and autoimmunity; how the immune system clears infection, avoids autoimmunity and how infection impacts on the development of immune responses.

• 
  Davis, Mark 
  Academic Appointments

  • Professor, Microbiology & Immunology
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Molecular mechanisms of lymphocyte recognition and differentiation; molecular genetics and expression of T-cell receptor genes. Dynamics and functionality of specific T cell populations in human cancer.

• 
  Engleman, Edgar 
  Academic Appointments

  • Professor, Pathology
  • Professor, Medicine
  • Member, Cancer Center
  Clinical Focus

  • Pathology
  • Pathology and Laboratory Medicine
  Research Interest

  Dendritic cells, NK cells and T cells; functional proteins and genes; immunotherapeutic approaches to cancer and autoimmune disease.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Fathman, C 
  Academic Appointments

  • Professor, Medicine - Immunology & Rheumatology
  • Member, Cancer Center
  Clinical Focus

  • Immunology
  • Immunology and Rheumatology
  Research Interest

  My lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity. We use lentiviral mediated transduction of murine dendritic cells with immunoregulatory proteins for site specific and targeted immunotherapy. We have idintified a gene (GRAIL) that seems to control T cell anergy and are defining the regulatory T cell core transcriptome. Additional studies are on the mechanism of effect of anti-CD3 antibodies in therapy of T1D.

• 
  Galli, Stephen 
  Academic Appointments

  • Professor, Pathology - Mouse Transgenic Facility
  • Professor, Microbiology & Immunology
  • Member, Bio-X
  • Member, Cancer Center
  Clinical Focus

  • Pathology
  • Pathology and Laboratory Medicine
  Research Interest

  The goals of Dr. Galli's laboratory are to understand the regulation of mast cell and basophil development and the expression of mast cell and basophil function, and to develop and use genetic approaches to elucidate the roles of these cells in health and disease.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Garcia, Chris 
  Academic Appointments

  • Professor, Molecular & Cellular Physiology
  • Professor, Structural Biology
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Structural and functional studies of transmembrane receptor interactions with their ligands in systems relevant to human health and disease - primarily in immunity, infection, and neurobiology. We study these problems using protein engineering, structural, biochemical, and combinatorial biology approaches.

• 
  Herzenberg, Leonore A
  Academic Appointments

  • Professor (Research), Genetics
  • Member, Cancer Center
  Research Interest

  B-cell development; Ig rearrangement and repertoire analysis; T cell regulation of antibodyresponses; T cell subsets; glutathione regulation of HIV disease progression; Fluorescence-Activated Cell Sorting (FACS) related software development and gene arrays.

• 
  Ji, Hanlee P
  Academic Appointments

  • Assistant Professor, Medicine - Oncology
  • Member, Cancer Center
  Clinical Focus

  • Medical Oncology
  • Oncology (Cancer)
  • Gastrointestinal Neoplasms
  Research Interest

  Cancer genomics and genetics, translational applications of next generation sequencing technologies, development of molecular signatures as prognostic and predictive biomarkers in oncology, primary genomic and proteomic technology development

• 
  Krensky, Alan 
  Academic Appointments

  • Emeritus Faculty, Acad Council, Pediatrics
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Mechanisms and therapies for infection, cancer, autoimmunity and transplantation.

• 
  Lee, Peter 
  Academic Appointments

  • Associate Professor, Medicine - Hematology
  • Member, Cancer Center
  Clinical Focus

  • Hematology
  • Leukemia - Hematology
  Research Interest

  Understanding the biology of cancer-T cell interactions.

• 
  Lewis, David 
  Academic Appointments

  • Professor - Med Center Line, Pediatrics - Immunology & Transplant Biology
  • Member, Cancer Center
  Clinical Focus

  • Infectious Diseases, Pediatric
  • Pediatric Infectious Disease
  Research Interest

  My laboratory has two major research interests. First, to define cellular and molecular mechanisms that limit T cell responses to vaccines and pathogens during normal early postnatal development and in cases of inherited genetic immunodeficiencies. Second, to determine how these limitations in immunity can be overcome by using novel approaches for vaccine adjuvants, with a particular focus on anti-viral vaccines.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Martinez, Olivia 
  Academic Appointments

  • Professor (Research), Surgery - Multi-Organ Transplantation
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Cell death pathways in EBV B cell lymphomas; role of cytokines and immunosuppression in growth and survival of EBV B cell lymphomas; cytokine pathways in graft rejection; identification of regulatory T cell subsets in alloreactivity; role of co-stimulation in alloreactivity;

• 
  Parnes, Jane 
  Academic Appointments

  • Emeritus Faculty, Acad Council, Medicine - Immunology & Rheumatology
  • Member, Cancer Center
  Research Interest

  The lab is studying the mechanisms controlling B cell responsiveness and the balance between tolerance and autoimmunity. B cells deficient in CD72 are hyperresponsive to stimulation through the B cell receptor. We are examining the alterations in B cell signaling in these B cells and the mechanisms by which CD72 deficiency partially abrogates anergic tolerance. We hope to learn how deficiency in CD72 leads to spontaneous autoimmunity and increased susceptibility to induced autoimmune disease.