Department: Cancer Center

Division: Molecular Profiling

• Faculty (19)
• Postdocs (0)
• All

• 
  Bogyo, Matthew 
  Academic Appointments

  • Associate Professor, Pathology
  • Associate Professor, Microbiology & Immunology
  • Associate Professor (By courtesy), Chemical and Systems Biology
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Our lab uses chemical, biochemical, and cell biological methods to study protease function in human disease. Projects include: 1) Design and synthesis of novel chemical probes for each of the primary protease families. 2) Understanding the role of proteolysis in the life cycle of the human parasites, Plasmodium falciparum and Toxoplasma gondii. 3) Defining the specific functional roles of proteases during the process of tumorogenesis. 4) In vivo imaging of protease activity

• 
  Brooks, James D
  Academic Appointments

  • Associate Professor, Urology
  • Member, Cancer Center
  • Member, Bio-X
  Clinical Focus

  • Male Cancers - Prostate
  • Prostate Cancer
  • Nerve-sparing radical prostatectomy
  Research Interest

  We have used comprehensive gene expression profiling for 2 translational research objectives: 1) to understand the mechanisms of action of candidate prostate cancer preventive agents and develop biomarkers that we can use to evaluate response; and 2) to identify diagnostic and prognostic markers for prostate, kidney, testicular and bladder cancers.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Brown, Patrick 
  Academic Appointments

  • Professor, Biochemistry
  • Member, Cancer Center
  Research Interest

  Dr. Brown's research group uses diverse experimental and computational methods to investigate the logic and mechanisms that control a genome's expression program. The Brown laboratory is systematically characterizing the genetic scripts that control the expression of our genes, in normal development and physiology and in diseases like cancer, with a particular focus on post-transcriptional regulation. The Brown lab also develops strategies and assays for early detection and diagnosis of cancer.

• 
  Chang, Howard Y
  Academic Appointments

  • Associate Professor, Dermatology
  • Member, Bio-X
  • Member, Cancer Center
  Clinical Focus

  • Dermatology
  Research Interest

  The Chang group is focused on two fundamental questions in epithelial biology: (1) the basis of positional identities in epidermal structures throughout the body, and (2) how those signals and boundaries may be abrogated to allow cancer metastasis. We are investigating the roles of site-specific fibroblast differentiation in patterning the epidermis, and dissecting the mechanisms of wound healing programs in cancer metastasis.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Chu, Gilbert 
  Academic Appointments

  • Professor, Medicine - Oncology
  • Professor, Biochemistry
  • Member, Bio-X
  • Member, Cancer Center
  Clinical Focus

  • Oncology
  Research Interest

  Our laboratory focuses on understanding how cells respond to DNA damage. Our research currently involves areas that interact with each other: repair of radiation damage, and transcriptional responses to DNA damage.

• 
  Dahl, Gary 
  Academic Appointments

  • Professor - Med Center Line, Pediatrics - Hematology/Oncology
  • Member, Cancer Center
  Clinical Focus

  • Hematology/Oncology/Stem Cell Transplant, Pediatric
  • Oncology (Cancer), Pediatric
  • Pediatric Hematology-Oncology
  Research Interest

  Hematology/Oncology, Phase I drug studies for childhood cancer, overcoming multidrug resistance in leukemia and solid tumors, biology and treatment of acute nonlymphocytic leukemia, early detection of central nervous system leukemia by measuring growth, factor binding proteins.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Efron, Bradley 
  Academic Appointments

  • Professor, Statistics
  • Professor, Health Research & Policy - Biostatistics
  • Member, Cancer Center
  Research Interest

  Theories of inference applied to biostatistical data;, the bootstrap method.

• 
  Harbury, Pehr 
  Academic Appointments

  • Associate Professor, Biochemistry
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Our lab engineers proteins and small-molecule drugs at atomic resolution through a combination of structural calculations and combinatorial library synthesis. Our goal is to elucidate predictive principles by which novel shapes and catalytic properties can be conferred accurately on designed polypeptides.

• 
  Hastie, Trevor J
  Academic Appointments

  • Professor, Statistics
  • Professor, Health Research & Policy - Biostatistics
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Flexible statistical modelling, datamining, bioinformatics, and statistical computing.

• 
  Herschlag, Daniel 
  Academic Appointments

  • Professor, Biochemistry
  • Professor (By courtesy), Chemical Engineering
  • Professor (By courtesy), Chemistry
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Our research is aimed at understanding the chemical and physical behavior underlying biological macromolecules and systems, as these behaviors define the capabilities and limitations of biology. Toward this end we study folding and catalysis by RNA, as well as catalysis by protein enzymes.

• 
  Jeffrey, Stefanie 
  Academic Appointments

  • Associate Professor - Med Center Line, Surgery - General Surgery
  • Member, Bio-X
  • Member, Cancer Center
  Clinical Focus

  • Surgical Oncology
  • Breast Surgery
  • General Surgery
  Research Interest

  Lab research: development of robot to isolate live circulating tumor cells (CTCs); characterization of live CTCs and their role in metastatic process; breast cancer genomics using DNA microarrays; refinement of RNA amplification techniques; co-developer of NASA Smart Probe for in-vivo breast tumor analysis

• 
  Longacre, Teri A
  Academic Appointments

  • Professor - Med Center Line, Pathology
  • Member, Cancer Center
  Clinical Focus

  • Anatomic/Clinical Pathology
  • Pathology and Laboratory Medicine
  Research Interest

  Gynecological, breast and gastrointestinal pathology with major emphasis on ovarian cancer and ovarian tumors of low malignant potential. Pathology of familial and hereditary breast-ovarian-GI cancer.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Lowe, Anson 
  Academic Appointments

  • Associate Professor, Medicine - Gastroenterology & Hepatology
  • Associate Professor (By courtesy), Molecular & Cellular Physiology
  • Member, Cancer Center
  Clinical Focus

  • Gastroenterology
  • Barrett's esophagus
  • Pancreatic Diseases
  Research Interest

  Pancreatic and esophageal cancers are common and deadly cancers of the gastrointestinal tract. Our laboratory is currently focused on the identification and characterization of candidate genes important in tumor growth. Such genes will also serve as potential therapeutic targets. An additional focus of the laboratory is the development of diagnostic assays for the early detection of pancreatic and esophageal disease.

• 
  Pollack, Jonathan R
  Academic Appointments

  • Associate Professor, Pathology
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Our laboratory uses genomics approaches to explore patterns of gene expression and gene copy number alteration in both human cancer cell line model systems and in tumors, with the goals of better understanding cancer, and developing novel diagnostic and therapeutic strategies.

• 
  Relman, David 
  Academic Appointments

  • Professor, Medicine - Infectious Diseases
  • Professor, Microbiology & Immunology
  • Member, Cancer Center
  • Member, Bio-X
  Clinical Focus

  • Infectious Disease
  • Infectious Diseases
  Research Interest

  My investigative program focuses on human-microbe interactions and human microbial ecology, and is divided into two research areas: 1) Ecology of human indigenous microbial communities; 2) Classification of humans and non-human primates with systemic infectious diseases, based on features of genome-wide gene transcript abundance patterns.

• 
  Rockson, Stanley 
  Academic Appointments

  • Professor - Med Center Line, Medicine - Cardiovascular Medicine
  • Member, Cancer Center
  Clinical Focus

  • Lymphatic Diseases
  • Cardiology (Heart)
  • Cardiology (Heart), Preventive
  Research Interest

  My clinical research includes studies on risk factor modification in atherosclerosis and coronary artery disease; clinical trials involving medical therapies for peripheral arterial insufficiency; coronary angiogenesis; therapy of lymphedema; atherand photodynamic therapy in atherosclerosis.

• 
  Sherlock, Gavin J
  Academic Appointments

  • Assistant Professor (Research), Genetics
  • Member, Cancer Center
  Research Interest

  Evolution and the adaptive landscape using yeast as a model; Defining yeast transcriptomes; chromosomal evolution in hybrid yeast species; genome database for Candida albicans; genome database for Aspergilli; the Stanford Microarray Database; The Tuberculosis Database; bioinformatics tools for analysing expression data.

• 
  Spudich, James 
  Academic Appointments

  • Professor, Biochemistry
  • Professor, Developmental Biology
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  The general research interest of this laboratory is the molecular basis of cell motility. We have three specific research interests, the molecular basis of energy transduction that leads to ATP-driven myosin movement on actin, the biochemical basis of the regulation of actin and myosin interaction and their assembly states, and the roles these proteins play in vivo, in cell movement and changes in cell shape.

• 
  Tibshirani, Robert 
  Academic Appointments

  • Professor, Health Research & Policy - Biostatistics
  • Professor, Statistics
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  My research is in applied statistics and biostatistics. I specialize in computer-intensive methods for regression and classification, bootstrap, cross-validationand statistical inference, and signal and image analysis for medical diagnosis.