Department: Cancer Center

Division: Cancer Stem Cells

• Faculty (34)
• Postdocs (0)
• All

• 
  Clarke, Michael F
  Academic Appointments

  • Professor, Medicine - Oncology
  • Member, Bio-X
  • Member, Cancer Center
  Clinical Focus

  • Colorectal Cancer
  • Oncology
  • Oncology (Cancer)
  Research Interest

  Dr. Michael F. Clarke is the Associate Director of the Stanford Institute for Stem Cell and Regenerative Medicine. In addition to his clinical duties in the division of Oncology, Dr. Clarke maintains a laboratory focused on two areas of research: i) the control of self-renewal of normal stem cells and their malignant counterparts; and ii) the identification and characterization of cancer stem cells. A central issue in stem cell biology is to understand the mechanisms that regulate self-renewa..

• 
  Crabtree, Gerald 
  Academic Appointments

  • Professor, Pathology
  • Professor, Developmental Biology
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  The role of chromatin in stem cell formation and function. Development of small molecule regulators as experimental probes and therapeutic leads. Signaling through calcineurin and NFAT in vertebrate development.

• 
  Edwards, Michael 
  Academic Appointments

  • Professor - Med Center Line, Neurosurgery
  • Professor - Med Center Line (By courtesy), Pediatrics
  • Member, Cancer Center
  Clinical Focus

  • Neurological Surgery
  • Neurosurgery
  • Neurosurgery, Pediatric
  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Fuller, Margaret 
  Academic Appointments

  • Professor, Developmental Biology
  • Professor, Genetics
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Regulation of stem cell division and self-renewal Cell type specific transcription machinery and regulation of cell differentiation Developmental regulation of cell cycle progression during male meiosis Molecular dissection of the mechanism of cytokinesis.

• 
  Gill, Harcharan 
  Academic Appointments

  • Associate Professor - Med Center Line, Urology
  • Member, Cancer Center
  Clinical Focus

  • Bladder Cancer - Urologic Oncology
  • Bladder Cancer
  • Kidney Cancer
  Research Interest

  Benign Prostatic Hyperplasia- Evaluation and development of new minimally invasive techniques Endourology: developing, designing and evaluating new instruments Bladder cancer: outcomes of treatment BPH: cryotherapy and HIFU

• 
  Gonzalgo, Mark L
  Academic Appointments

  • Associate Professor - Med Center Line, Urology
  • Member, Cancer Center
  Clinical Focus

  • Prostate Cancer - Robotic Prostatectomy
  • Bladder Cancer - Robotic Cystectomy
  • Urologic Oncology - Prostate, Bladder, Kidney, Testicular Cancer
  Research Interest

  My laboratory is focused on studying the role of DNA methylation in prostate and bladder cancer. Certain genes and their downstream targets may be useful molecular markers for disease detection and prognostication. We are interested in utilizing methylation markers to detect abnormal changes in serum and urine. Clinical Focus: Prostate Cancer - Robotic Prostatectomy; Bladder Cancer - Robotic Cystectomy; Urologic Oncology - Prostate, Bladder, Kidney, Testicular Cancer.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Gotlib, Jason 
  Academic Appointments

  • Assistant Professor - Med Center Line, Medicine - Hematology
  • Member, Cancer Center
  Clinical Focus

  • Hematology
  Research Interest

  My research interests include phase I/II clinical trial evaluation of novel therapies for the following diseases: --Myelodysplastic syndromes (MDS) --Chronic myelogenous leukemia (CML) --Acute myelogenous leukemia (AML) --Myeloproliferative disorders (MPDs) including: Hypereosinophilic syndrome Systemic mastocytosis BCR-ABL-negative MPDs

• 
  Guardino, Alice 
  Academic Appointments

  • Assistant Professor - Med Center Line, Medicine - Oncology
  • Member, Cancer Center
  Clinical Focus

  • Breast Cancer
  • Medical Oncology
  • Immune Therapy and Vaccines
  Research Interest

  Dr. Guardino has studied the mechanisms by which the immune system recognizes foreign substances like viruses, microorganisms and cancer and the ways the immune system becomes deregulated and attacks “self” as seen in autoimmunity. Her research identified the cellular interactions involved in immune recognition and has led to treatment strategies for cancer using immune therapies and biologic treatments.

• 
  Harsh, Griffith 
  Academic Appointments

  • Professor - Med Center Line, Neurosurgery
  • Professor - Med Center Line (By courtesy), Otolaryngology (Head and Neck Surgery)
  • Member, Bio-X
  • Member, Cancer Center
  Clinical Focus

  • Acoustic Neuroma
  • Acoustic Neuroma - Head and Neck Surgery
  • Brain / Central Nervous System Tumors
  Research Interest

  Microsurgical treatment of tumors of the brain, spinal cord, pituitary gland and skull base; Radiosurgery of tumors; Molecular biology of brain tumors.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Huhn, Stephen 
  Academic Appointments

  • Member, Cancer Center
  Clinical Focus

  • Neurological Surgery
  • Neurosurgery
  • Neurosurgery, Pediatric
  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Husain, Amreen 
  Academic Appointments

  • Associate Professor - Med Center Line, Obstetrics & Gynecology
  • Member, Cancer Center
  Clinical Focus

  • Cervix Cancer
  • Cervix Cancer - Gynecologic Oncology
  • Endometrial Cancer
  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Johnson, Denise 
  Academic Appointments

  • Associate Professor - Med Center Line, Surgery - General Surgery
  • Member, Cancer Center
  Clinical Focus

  • Breast Cancer - Surgery
  • General Surgery
  • Melanoma - Surgery
  Research Interest

  Study of the impact of tumor bearing regional lymph nodes in solid tumors and immune profile of the tumor draining lymph nodes. Metabolic tumor detection and intraoperative detection using specially designed detection probes. Gene and Protein profile of primary melanoma and breast tumors including stem cell analysis.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Kaplan, Michael 
  Academic Appointments

  • Professor - Med Center Line, Otolaryngology (Head and Neck Surgery)
  • Professor - Med Center Line (By courtesy), Neurosurgery
  • Member, Cancer Center
  Clinical Focus

  • Head and Neck Cancers
  • Head and Neck Cancers - Head and Neck Surgery
  • Skull Base Tumors
  Research Interest

  1) New therapeutic approaches for head and neck cancer, including immune stimulation possibilities (IRX-2 protocol), integration of biological modifiers, and, eventually, genetic approaches. 2) Head and neck cancer stem cells: identification, characterization, control--in conjunction with the Irv Weissman and Michael Clarke labs in the Stem Cell Institute 3) Development of innovative surgical methods at the anterior cranial base

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Kim, Seung 
  Academic Appointments

  • Professor, Developmental Biology
  • Professor (By courtesy), Medicine
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  We study the genetics of pancreatic islet cell differentiation using molecular, embryologic and genetic methods in several model systems, including mice, embryonic stem cells, and Drosophila. Our work suggests that critical factors required for islet development are also needed to maintain essential functions of the mature islet. Our knowledge of genetic and cellular pathways governing islet formation has allowed us to use stem cell lines to produce islet replacements in vitro.

• 
  Norton, Jeffrey 
  Academic Appointments

  • Professor - Med Center Line, Surgery - General Surgery
  • Member, Cancer Center
  Clinical Focus

  • Adrenal Cancer
  • Carcinoid Tumors
  • Carcinoid Tumors - Endocrinology
  Research Interest

  Interleukin-12 is a Th1 cytokine. It is important in the cell mediated immune response. We are investigating its role as an anti-tumor cytokine to augment the immune response against cancer. We are planning a human trial.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Nusse, Roeland 
  Academic Appointments

  • Professor, Developmental Biology
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Our laboratory studies Wnt signaling in development and disease. We found recently that Wnt proteins are unusual growth factors, because they are lipid-modified. We also discovered that Wnt proteins promote the proliferation of stem cells of various origins. Current work is directed at understanding the function of the lipid on the Wnt, using Wnt proteins as factors the expand stem cells and on understanding Wnt signaling during injury repair and regeneration.

• 
  Palmer, Theo D
  Academic Appointments

  • Associate Professor, Neurosurgery
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  For most areas of the mammalian brain, neurogenesis concludes at birth but there are exceptions to the rule. In rodents and humans, some areas of the brain continue to make new neurons throughout life. This process is mediated by neural stem cells and our research goals are to understand how stem cell activity is regulated and whether the nascent potential of resident stem cells can be harnessed for brain repair.

• 
  Presti, Joseph 
  Academic Appointments

  • Professor - Med Center Line, Urology
  • Member, Cancer Center
  Clinical Focus

  • prostate cancer
  • bladder cancer
  • kidney cancer
  Research Interest

  refine detection strategies for prostate cancer, identify prognostic indicators for prostate cancer patients

• 
  Recht, Lawrence 
  Academic Appointments

  • Professor - Med Center Line, Neurology & Neurological Sciences
  • Professor - Med Center Line (By courtesy), Neurosurgery
  • Member, Cancer Center
  Clinical Focus

  • Neurology
  Research Interest

  Our laboratory focuses on two interrelated projects: (1) assessment of glioma development within the framework of the multistage model of carcinogenesis through utilization of the rodent model of ENU neurocarcinogenesis; and (2) assessment of stem cell specification and pluripotency using an embryonic stem cell model system in which neural differentiation is induced.

• 
  Reijo-Pera, Renee 
  Academic Appointments

  • Professor, Obstetrics & Gynecology - OB GYN Institutes
  • Member, Cancer Center
  • Member, Bio-X
  Research Interest

  The Reijo Pera Laboratory is focused on understanding key cell fates in the embryo, including the generation of pluripotent stem cells, somatic and germ cell lineages

• 
  Rosen, Glenn 
  Academic Appointments

  • Associate Professor, Medicine - Pulmonary & Critical Care Med
  • Member, Bio-X
  • Member, Cancer Center
  Clinical Focus

  • Pulmonary Disease
  • Pulmonology (Lung) and Critical Care
  Research Interest

  Our laboratory examines apoptotic and cell cycle pathways in cancer and lung disease. We have identified a novel cell cycle protein which regulates cell cycle progression in immune cells and the lung. We are also studying signaling pathways that regulate cancer cell growth and metastasis.

• 
  Scott, Matthew 
  Academic Appointments

  • Professor, Developmental Biology
  • Professor, Genetics
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Genetic regulation of animal development and human disease. We use mice and flies to study Hedgehog/Patched signaling and its links to brain cancer, development of the neural tube and cerebellum, planar cell polarity genes, a neurodegenerative disease called Niemann-Pick syndrome that affects intracellular organelle movements, chromatin proteins in embryonic stem cells, and genetic control of body size.

• 
  Shizuru, Judith 
  Academic Appointments

  • Associate Professor, Medicine - Division: Blood and Marrow Transplantation
  • Member, Cancer Center
  Clinical Focus

  • Blood and Marrow Transplantation
  • Hematology
  Research Interest

  Transplantation of defined populations of allogeneic hematopoietic cells. Specifically, the way in which hematopoietic cell grafts alter antigen specific immune responses to allo-, auto- and viral antigens. The cellular and molecular basis of resistance to engraftment of allogeneic hematopoietic stem cells.

• 
  Shortliffe, Linda 
  Academic Appointments

  • Professor, Urology
  • Member, Bio-X
  • Member, Cancer Center
  Clinical Focus

  • Urology, Pediatric
  • Pediatric Urology
  Research Interest

  The timing for intervention in hydronephrotic obstruction in the infant and child is poorly understood. Our group has been interested in trying to define the parameters that may be involved in obstructive and infectious uropathies and discovering early signs of damage to the urinary tract and kidney. For this reason we have explored news ways of imaging and evaluating the urinary tract and kidney. We have study the effects of sex steroid hormones and urinary tract infections.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Skirboll, Stephen 
  Academic Appointments

  • Assistant Professor - Med Center Line, Neurosurgery
  • Member, Bio-X
  • Member, Cancer Center
  Clinical Focus

  • Neurological Surgery
  • Neurosurgery
  Research Interest

  My research focuses on the identification and characterization of cancer stem cells in human brain tumors, particularly malignant gliomas. We are pursuing this with several projects: 1) developing screening strategies using a novel colony-forming antibody live cell microarray, and 2) a novel micro-immunopanning device, 3) phage display to identify tumor specific markers and screen for cancer stem cells using assays in #1 and #2, and 4) examining EGFRvIII as a possible cancer stem cell marker

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  So, Samuel 
  Academic Appointments

  • Professor - Med Center Line, Surgery - General Surgery
  • Member, Cancer Center
  Clinical Focus

  • Gastrointestinal Cancers
  • Gastrointestinal Cancers - Surgical Oncology
  • General Surgery
  Research Interest

  Through a 3 pronged comprehensive program: translational and clinical research, early detection and treatment, and promoting education, awareness and immunization, we are working towards the development of new strategies that will lead to the elimination of hepatitis B worldwide and reduce the threat and incidence of liver cancer. Our current research efforts focus on evaluating potential new diagnostic and treatment markers and novel targeted therapy for primary liver cancer.

• 
  Srinivas, Sandhya 
  Academic Appointments

  • Associate Professor - Med Center Line, Medicine - Oncology
  • Member, Cancer Center
  Clinical Focus

  • Bladder Cancer
  • Bladder Cancer - Medical Oncology
  • Germ Cell Tumors
  Research Interest

  Clinical interests: general oncology, genito-urinary malignancy Research interests: conducting clinical trials in advanced prostate cancer, bladder cancer and renal cell carcinoma

• 
  Sunwoo, John 
  Academic Appointments

  • Assistant Professor, Otolaryngology (Head and Neck Surgery)
  • Member, Cancer Center
  Clinical Focus

  • Thyroid Neoplasms
  • Parathyroid Neoplasms
  • Head and Neck Cancer
  Research Interest

  My laboratory is focused on two primary areas of research: (1) the immune response to head and neck cancer and to a tumorigenic population of cells within these malignancies called cancer stem cells; (2) the developmental programs of a special lymphocyte population involved in innate immunity called natural killer (NK) cells.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Sylvester, Karl 
  Academic Appointments

  • Associate Professor - Med Center Line, Surgery - Pediatric Surgery
  • Member, Bio-X
  • Member, Cancer Center
  Clinical Focus

  • Pediatric Surgery
  • Surgery, Pediatric
  Research Interest

  Current research interests include mesenchymal stem cell biology, clonal isolation of mesenchymal progenitors, signaling pathways for maintenance of potency and committment to differentiation. Additional areas of ongoing study are the mechanisms of liver regeneration. Interests include local and humoral cellular components of liver repair and regrowth; and the requisite cellular signaling mechanisms of liver stem cell biology.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Teng, Nelson 
  Academic Appointments

  • Associate Professor, Obstetrics & Gynecology
  • Member, Cancer Center
  Clinical Focus

  • Cervix Cancer
  • Cervix Cancer - Gynecologic Oncology
  • Endometrial Cancer
  Research Interest

  Gynecologic Malignancies Immunotherapy Biologic Response Modifiers New Drug Development Antigenic specificities of human antibodies encoded by the VH4-34 gene

• 
  Tse, Victor 
  Academic Appointments

  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  My research focus is on tumor angiogenesis. We are working on the contributions of progenitor cells in the formation of tumor vessels. We are particularly interested in a population of cells that are derived from putative "hemangioblast", and their role in vasculogenesis. We sumrise that these cells have a close association with cancer stem cells, and are essential in promoting tumor expansion.

• 
  Vogel, Hannes 
  Academic Appointments

  • Professor - Med Center Line, Pathology
  • Professor - Med Center Line (By courtesy), Neurosurgery
  • Member, Cancer Center
  Clinical Focus

  • Pathology and Laboratory Medicine
  • Anatomic/Clinical Pathology
  Research Interest

  My research interests include nerve and muscle pathology, mitochondrial diseases, pediatric neurooncology, and transgenic mouse pathology.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Weissman, Irving 
  Academic Appointments

  • Professor, Pathology - Stem Cell Institute
  • Professor, Developmental Biology
  • Professor (By courtesy), Biology (School of Humanities and Sciences)
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Stem cell and cancer stem cell biology; development of T and B lymphocytes; cell-surface receptors for oncornaviruses in leukemia. Hematopoietic stem cells; Lymphocyte homing, lymphoma invasiveness and metastasis.

• 
  Wong, Wing 
  Academic Appointments

  • Professor, Statistics
  • Professor (By courtesy), Biology (School of Humanities and Sciences)
  • Professor, Health Research & Policy - Biostatistics
  • Member, Bio-X
  • Member, Cancer Center
  Research Interest

  Current interest centers on the application of statistics to problems arsing from biology. We are particularly interested in questions concerning gene regulation and signal transduction.