Department: Stanford Cancer Institute

Division: Radiation Biology

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• 
  Attardi, Laura 
  Academic Appointments Associate Professor,  Radiation Oncology - Radiation and Cancer Biology
  Member,  Bio-X
  Member,  Stanford Cancer Institute
  Associate Professor,  Genetics
  
  Research Interest

  Our research is aimed at defining the pathways of p53-mediated apoptosis and tumor suppression, using a combination of biochemical, cell biological, and mouse genetic approaches. Our strategy is to start by generating hypotheses about p53 mechanisms of action using primary mouse embryo fibroblasts (MEFs), and then to test them using gene targeting technology in the mouse.
• 
  Bouley, Donna 
  Academic Appointments Professor - Med Center Line,  Comparative Medicine
  Member,  Stanford Cancer Institute
  Professor - Med Center Line (By courtesy),  Pathology
  
  Research Interest

  Research interests: ocular pathology, host-pathogen interactions in infectious disease, infectious disease in frogs, phenotypic characterization of tg and ko mice, histopathology of minimally-invasive radiological ablation techniques (focused ultrasound, cryoablation).
• 
  Brown, Martin 
  Academic Appointments Professor,  Radiation Oncology - Radiation and Cancer Biology
  Member,  Stanford Cancer Institute
  
  Research Interest

  We seek to understand the mechanisms responsible for the resistance of cancers to treatment and to develop strategies to overcome these resistances. We are using molecular and cellular techniques and mouse models to potentiate the activity of radiation on tumors by inhibiting the bone marrow rescue of the tumor vasculature following therapy.
• 
  Cappelli, Mark 
  Academic Appointments Professor,  Mechanical Engineering
  Member,  Stanford Cancer Institute
  
• 
  Cochran, Jennifer 
  Academic Appointments Associate Professor,  Bioengineering
  Member,  Stanford Cancer Institute
  Member,  Child Health Research Institute
  Member,  Bio-X
  Associate Professor (By courtesy),  Chemical Engineering
  
  Research Interest

  Molecular Bioengineering, Protein Biochemistry and Biotechnology, Cell and Tissue Engineering, Molecular Imaging
• 
  Cornfield, David 
  Academic Appointments Professor,  Pediatrics - Pulmonary Medicine
  Member,  Stanford Cancer Institute
  Professor (By courtesy),  Surgery
  
  Clinical Focus

  • Pediatric Pulmonary
  • Pediatric Pulmonary Med
  • Pediatric Critical Care Medicine
  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Denko, Nicholas 
  Academic Appointments Member,  Stanford Cancer Institute
  
  Research Interest

  We are interested in the biologic effect of gene expression changes that occur in the solid tumor. Many of these expression changes are due to the micro-physiology within the tumor. Several of these genes have been implicated in driving malignant progression and/or regulating response to therapeutic intervention. We hope to use these molecular changes to develop novel targeted therapies that take advantage of tumor specific gene expression changes.
• 
  Donaldson, Sarah 
  Academic Appointments Professor,  Radiation Oncology - Radiation Therapy
  Member,  Stanford Cancer Institute
  
  Clinical Focus

  • Cancer  >  Cutaneous (Dermatologic) Oncology
  • Cancer  >  Lymphoma
  • Cancer  >  Radiation Oncology
  Research Interest

  Combined Modality Treatment of Cancer Late Effects of Treatment Genetic Effects of Cancer Rhabdomyosarcoma Hodgkins Disease Pediatric Radiation Oncolgy Pediatric Oncolgy Breast Cancer Conformal Radiotherapy/IMRT Radiotherapy for Benign Diseases

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Ford, James 
  Academic Appointments Associate Professor,  Medicine - Oncology
  Member,  Bio-X
  Member,  Stanford Cancer Institute
  Associate Professor,  Genetics
  Associate Professor (By courtesy),  Pediatrics
  
  Clinical Focus

  • Cancer  >  GI Oncology
  • Cancer Genetics
  • Gastrointestinal Cancers - Genetics
  Research Interest

  Mammalian DNA repair and DNA damage inducible responses; p53 tumor suppressor gene; transcription in nucleotide excision repair and mutagenesis; genetic determinants of cancer cell sensitivity to DNAdamage; genetics of inherited cancer susceptibility syndromes and human GI malignancies; clinical cancer genetics of BRCA1 and BRCA2 breast cancer and mismatch repair deficient colon cancer.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Giaccia, Amato 
  Academic Appointments Professor,  Radiation Oncology - Radiation and Cancer Biology
  Member,  Stanford Cancer Institute
  Professor (By courtesy),  Obstetrics & Gynecology
  Professor (By courtesy),  Surgery
  
  Research Interest

  During the last five years, we have identified several small molecules that kill VHL deficient renal cancer cells through a synthetic lethal screening approach. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We are also investigating how hypoxia regulates gene expression epigenetically.
• 
  Gibbs, Iris 
  Academic Appointments Associate Professor - Med Center Line,  Radiation Oncology - Radiation Therapy
  Member,  Stanford Cancer Institute
  
  Clinical Focus

  • Cancer  >  Radiation Oncology
  • Brain / Central Nervous System Tumors - Radiation Oncology
  • Cyberknife/radiosurgery
  Research Interest

  Dr. Gibbs is a board-certified radiation oncologist who specializes in the treatment of CNS tumors. Her research focuses on developing new radiation techniques to manage brain and spinal tumors in adults and children. Dr. Gibbs has gained worldwide acclaim for her expertise in Cyberknife robotic radiosurgery.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Graves, Edward 
  Academic Appointments Associate Professor,  Radiation Oncology - Radiation Physics
  Member,  Stanford Cancer Institute
  Member,  Bio-X
  Associate Professor (By courtesy),  Radiology - Diagnostic Radiology
  
  Research Interest

  Applications of molecular imaging in radiation therapy, development of hypoxia and radiosensitivity imaging techniques, small animal image-guided conformal radiotherapy, image processing and analysis.
• 
  Gurtner, Geoffrey C.
  Academic Appointments Professor - Med Center Line,  Surgery - Plastic & Reconstructive Surgery
  Member,  Stanford Cancer Institute
  Professor - Med Center Line (By courtesy),  Materials Science and Engineering - Engineering Materials Science
  
  Clinical Focus

  • Plastic Surgery
  • Plastic & Recon Surgery
  Research Interest

  Geoffrey Gurtner's Lab is interested in understanding the mecahnism of new blood vessel growth following injury and how pathways of tissue regeneration and fibrosis interact in wound healing.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Hanawalt, Philip C
  Academic Appointments Professor,  Biology (School of Humanities and Sciences)
  Member,  Stanford Cancer Institute
  Member,  Bio-X
  Professor,  Dermatology
  
  Research Interest

  Our current research focuses in two principal areas: 1. The molecular basis for diseases in which the pathway of transcription-coupled DNA repair is defective, including Cockyne syndrome (CS) and UV-sensitive syndrome (UVSS). Patients are severely sensitive to sunlight but get no cancers. See Hanawalt & Spivak, 2008, for review. 2. Transcription arrest by guanine-rich DNA sequences and non-canonical secondary structures. Transcription collisions with replication forks.
• 
  Hoppe, Richard 
  Academic Appointments Professor,  Radiation Oncology - Radiation Therapy
  Member,  Stanford Cancer Institute
  
  Clinical Focus

  • Cancer  >  Lymphoma
  • Cancer  >  Radiation Oncology
  • Lymphoma
  Research Interest

  Irradiation immunosuppression; total body irradiation;, psychosocial effects of cancer treatment; treatment of lymphoma;, mycosis fungoides.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Kapp, Daniel 
  Academic Appointments Emeritus Faculty, Acad Council,  Radiation Oncology - Radiation Therapy
  Member,  Stanford Cancer Institute
  
  Clinical Focus

  • Brain / Central Nervous System Tumors
  • Brain / Central Nervous System Tumors - Radiation Oncology
  • Breast Cancer
  Research Interest

  Gynecologic malignancies; Rectal/and cancer; Breast Cancer; Hodgkin's disease; Hyperthermia; intraoperative radiation therapy; High dose rate radiation therapy; Predictive assays; Patterns of tumor spread; Health care finance.
• 
  Knox, Susan 
  Academic Appointments Associate Professor,  Radiation Oncology - Radiation Therapy
  Member,  Bio-X
  Member,  Stanford Cancer Institute
  
  Clinical Focus

  • Cancer  >  Cutaneous (Dermatologic) Oncology
  • Cancer  >  Lymphoma
  • Cancer  >  Radiation Oncology
  Research Interest

  Our interests include 1) study of the effect of radiation on regulatory cell subpopulations and co-stimulatory molecules, 2) use of radiation as an immune modulator for optimization of transplant regimens, 3) the role of radiation in tumor vaccine strategies, 4) study of new radiosensitizers and radioprotectors, and 5) discovery of new targeted therapies for the treatment of solid tumors.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Koong, Albert 
  Academic Appointments Associate Professor,  Radiation Oncology - Radiation Therapy
  Member,  Bio-X
  Member,  Stanford Cancer Institute
  
  Clinical Focus

  • Cancer  >  GI Oncology
  • Cancer  >  Radiation Oncology
  • Pancreatic Cancer
  Research Interest

  The focus of my laboratory is to understand the role of hypoxia and the tumor microenvironment on malignant progression. My clinical area of interest is in the application of chemoradiotherapy and stereotactic body radiotherapy (SBRT) for GI malignancies.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Lazzeroni, Laura 
  Academic Appointments Associate Professor (Research),  Psychiatry & Behavioral Science
  Member,  Stanford Cancer Institute
  Member,  Bio-X
  Member,  Child Health Research Institute
  
• 
  Le, Quynh-Thu 
  Academic Appointments Professor - Med Center Line,  Radiation Oncology - Radiation Therapy
  Member,  Stanford Cancer Institute
  Member,  Bio-X
  Professor - Med Center Line (By courtesy),  Otolaryngology (Head and Neck Surgery)
  
  Clinical Focus

  • Cancer  >  Head and Neck Cancer
  • Cancer  >  Radiation Oncology
  • Lung Cancer - Radiation Oncology
  Research Interest

  My laboratory research interest focuses on the identification of biomarkers for prognosis in patients with head & neck or lung cancers. I am also conducting a number of clinical trials specifically in patients with head & neck cancers.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Longaker, Michael 
  Academic Appointments Professor,  Surgery - Plastic & Reconstructive Surgery
  Member,  Child Health Research Institute
  Member,  Stanford Cancer Institute
  Member,  Bio-X
  Professor (By courtesy),  Bioengineering
  Professor (By courtesy),  Materials Science and Engineering - Engineering Materials Science
  
  Clinical Focus

  • Plastic Surgery
  • Plastic Surgery, Pediatric
  Research Interest

  We have six main areas of current interest: 1) Cranial Suture Developmental Biology, 2)Distraction Osteogenesis, 3) Cleft Palate and Lip Biology, 4)Keloid and Hypertrophic Scar Biology, 5) Scarless Fetal Wound Healing, 6) Novel Gene and Stem Cell Therapeutic Approaches.

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Loo, Billy 
  Academic Appointments Assistant Professor - Med Center Line,  Radiation Oncology - Radiation Therapy
  Member,  Stanford Cancer Institute
  Member,  Bio-X
  
  Clinical Focus

  • Cancer  >  Head and Neck Cancer
  • Cancer  >  Radiation Oncology
  • Cancer  >  Thoracic Oncology
  Research Interest

  My clinical specialties are radiation treatment of lung and head & neck cancers, and I serve as the Tthoracic Radiation Oncology Program Leader. My research interests include 4-D multimodality imaging of tumor and organ motion using CT, PET, and MR; novel functional/metabolic imaging of tumor hypoxia, normal tissue inflammation, and lymphatic drainage; high-precision image-guided radiation therapy including 4-D IMRT, dynamic arc therapy, and stereotactic ablative radiotherapy (SABR).

  Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
• 
  Mitchell, Beverly S
  Academic Appointments Professor,  Medicine - Oncology
  Member,  Stanford Cancer Institute
  Professor,  Medicine - Hematology
  Professor (By courtesy),  Chemical and Systems Biology
  
  Clinical Focus

  • Cancer  >  Hematology
  • Cancer  >  Hematology  > Hematologic Malignancies
  • Cancer  >  Lymphoma
  Research Interest

  Beverly Mitchell's research relates to the development of new therapies for hematologic malignancies, including leukemias and myelodsyplastic syndromes. She is interested in preclinical proof of principle studies on mechanisms inducing cell death and on metabolic targets involving nucleic acid biosynthesis in malignant cells. She is also interested in the translation of these studies into clinical trials.
• 
  Morrison, Ashby 
  Academic Appointments Assistant Professor,  Biology (School of Humanities and Sciences)
  Member,  Stanford Cancer Institute
  
  Research Interest

  Our research interests are to elucidate the contribution of chromatin to mechanisms that promote genomic integrity.
• 
  Peehl, Donna 
  Academic Appointments Professor (Research),  Urology
  Member,  Bio-X
  Member,  Stanford Cancer Institute
  
  Research Interest

  My research focuses on the molecular and cellular biology of the human prostate. Developing realistic experimental models is a major goal, and primary cultures of prostatic epithelial and stromal cells are my main model system. Our discoveries are relevant to prevention, detection, diagnosis and treatment of benign and malignant prostatic diseases.
• 
  Tibshirani, Robert 
  Academic Appointments Professor,  Health Research & Policy - Biostatistics
  Member,  Stanford Cancer Institute
  Member,  Bio-X
  Professor,  Natural Sciences Cluster - Statistics
  
  Research Interest

  My research is in applied statistics and biostatistics. I specialize in computer-intensive methods for regression and classification, bootstrap, cross-validationand statistical inference, and signal and image analysis for medical diagnosis.
• 
  Xing, Lei 
  Academic Appointments Professor,  Radiation Oncology - Radiation Physics
  Member,  Bio-X
  Member,  Stanford Cancer Institute
  
  Research Interest

  Image-guided intervention, MR spectroscopic imaging (MRSI) and radionuclide imaging (PET/CT, SPECT/CT), biologically conformable radiation threapy (BCRT), intensity modulated radiation therapy (IMRT), treatment plan optimization, optimization of stereotactic radiosurgery, image segmentation and deformable image registration, application of molecular imaging to radiation oncology.