Or Gozani
Academic Appointments
- Associate Professor, Biology (School of Humanities and Sciences)
- Member, Stanford Cancer Institute
Key Documents
Contact Information
- Academic Offices
Personal Information EmailAlternate Contact Shalien Izzi Administrative Associate Email Tel Work 650-724-1512
Professional Overview
Honors and Awards
- Ellison Senior Scholar in Aging, Ellison Medical Foundation (2009-2013)
- Searle Scholar, Searle Scholars Program (2007-2010)
- Terman Fellowship, Fredrick E. Terman Foundation (2006-2008)
- Kimmel Scholar Award, Sidney Kimmel Foundation for Cancer Research (2006-2008)
- Career Award in the Biomedical Sciences, Burroughs Wellcome Fund (2003 - 2008)
- Mentored Clinical Scientist Development Award (KO8), NIA (2002 - 2007)
Postdoctoral Advisees
Scott Carlson, Peggie Cheung, Erin Green, Jen-Hao Kuo, Gloria Mas Martin, Nicolas Reynoird
Graduate & Fellowship Program Affiliations
Internet Links
Scientific Focus
Current Research Interests
We study the molecular mechanisms by which chromatin-signaling networks effect nuclear and epigenetic programs, and how dysregulation of these pathways leads to disease. Our work centers on the biology of lysine methylation, a principal chromatin-regulatory mechanism that directs epigenetic processes. We study how lysine methylation events are generated, sensed, and transduced, and how these chemical marks integrate with other nuclear signaling systems to govern diverse cellular functions.
Publications
- A general molecular affinity strategy for global detection and proteomic analysis of lysine methylation. Mol Cell. 2013; (3): 444-56
- Methylation of H4 lysines 5, 8 and 12 by yeast Set5 calibrates chromatin stress responses. Nat Struct Mol Biol. 2012; (3): 361-3
- The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome. Nature. 2012; (7392): 115-9
- Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling. Nat Immunol. 2011; (1): 29-36
- NSD2 links dimethylation of histone H3 at lysine 36 to oncogenic programming. Mol Cell. 2011; (4): 609-20
- ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature. 2006; (7098): 96-9
Help
Trial Administration