Lawrence Chu, MD, MS
Academic Appointments
- Associate Professor - Med Center Line, Anesthesia
- Member, Bio-X
Key Documents
Contact Information
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Clinical Offices
Department of Anesthesia 300 Pasteur Dr H3580 MC 5640 Stanford, CA 94305 Tel Work (650) 724-2970 Fax (650) 725-8544Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Alternate Contact Ms. Fizaa Ahmed Administrative Assistant Email Tel Work 650-723-4671Not for medical emergencies or patient use
Professional Overview
Clinical Focus
- Anesthesia
- eHealth
- Emerging Technology and Medicine
Administrative Appointments
- Executive Director, Stanford Medicine X (2011 - present)
- Organizing Chair, Fourth World Congress on Social Media and Web 2.0 in Health, Medicine and Biomedical Research (2010 - 2011)
- Member, Committee on Admissions, Stanford University School of Medicine (2007 - present)
- Member, Web Site Committee, American Pain Society (2007 - present)
- Member, Educational Resources Committee, Society for Education in Anesthesia (2003 - present)
- Member, Editorial Board, MDNetGuide (1999 - present)
Honors and Awards
- Innovation in Education Award, International Anesthesia Research Society (2011-2012)
- Career Development Award, National Institutes of Health (8/2004-8/2009)
- Clinical Loan Repayment Program, National Institutes of Health (7/2003 - Present)
- Research Fellowship Grant, Foundation for Anesthesia Education and Research (1/2003-6/2004)
- Excellence in Teaching Award, Stanford University Department of Biological Sciences (1998)
Professional Education
| Board Certification: | Anesthesia, American Board of Anesthesiology (2004) |
| Internship: | St. Mary's Hospital and Medical Center, CA USA (2000) |
| Medical Education: | Stanford University School of Medicine CA (1999) |
| MS: | Stanford University, Clinical Epidemiology (2006) |
| Fellowship: | Stanford Medical School, Clinical Pain Research (2004) |
| Residency: | Stanford Hospital, Anesthesiology (2003) |
Graduate & Fellowship Program Affiliations
Scientific Focus
Current Research Interests
I have two lines of research, one involving educational informatics and use of technology in postgraduate medical education and another involving NIH-funded work in patient-oriented clinical research regarding opioid use and physiologic responses associated with acute and chronic exposure in humans.
For a full description of my educational informatics work, please see my website aim.stanford.edu.
My clinical research focuses on the study opiate-induced hyperalgesia in patients suffering from chronic pain.
I am currently conducting an NIH-funded five year double-blinded randomized controlled clinical study (NIGMS award 1K23GM071400-01) that prospectively examines the following hypotheses: 1) pain patients on chronic opioid therapy develop dose-dependent tolerance and/or hyperalgesia to these medications over time, 2) opiate-induced tolerance and hyperalgesia develop differently with respect to various types of pain, 3) opioid-induced hyperalgesia occurs independently of withdrawal phenomena, and 4) opiate-induced tolerance and hyperalgesia develop differently based on gender and/or ethnicity.
The study is the first quantitative and prospective examination of tolerance and hyperalgesia in pain patients and may have important implications for the rational use of opioids in the treatment of chronic pain.
Clinical Trials
- Not Recruiting Opiate-Induced Tolerance & Hyperalgesia in Pain Patients
- Recruiting A Study of Genetic Variation Influencing Pain and Response to Opioid Medications in Patients With Chronic Pain
- Recruiting Functional Magnetic Resonance Imaging of Opioid Withdrawal in Healthy Human Volunteers
- Recruiting 5HT3 Antagonists to Treat Opioid Withdrawal and to Prevent the Progression of Physical Dependence
- Recruiting Study on the Effect of a Beta Blocker on Increased Sensitivity to Pain in Humans Caused by Opioids
Publications
- Analgesic tolerance without demonstrable opioid-induced hyperalgesia: a double-blinded, randomized, placebo-controlled trial of sustained-release morphine for treatment of chronic nonradicular low-back pain. Pain. 2012; (8): 1583-92
- Information technology and its role in anaesthesia training and continuing medical education. Best Pract Res Clin Anaesthesiol. 2012; (1): 33-53
- Mobile computing in medical education: opportunities and challenges. Curr Opin Anaesthesiol. 2012; (6): 699-718
- Modulation of remifentanil-induced postinfusion hyperalgesia by the β-blocker propranolol in humans. Pain. 2012; (5): 974-81
- A sensitive assay for the quantification of morphine and its active metabolites in human plasma and dried blood spots using high-performance liquid chromatography-tandem mass spectrometry. Anal Bioanal Chem. 2011; (3): 715-28
- Analysis of 4999 online physician ratings indicates that most patients give physicians a favorable rating. J Med Internet Res. 2011; (4): e95
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