Tony Wyss-Coray
Academic Appointments
- Professor, Neurology & Neurological Sciences
- Member, Child Health Research Institute
Key Documents
Contact Information
- Academic Offices
Personal Information Email
Professional Overview
Honors and Awards
- Senior Research Career Scientist, Veterans Administration (2012)
- Zenith Award, Alzheimer's Association (2005)
- Distinguished Scholar Award, The John Douglas French Alzheimers Foundation (2005)
- Editor, Journal of Neuroinflammation (2004)
- Medical and Scientific Advisory Council, Alzheimer's Association of Northern California & Northern Nevada (2004)
Professional Education
| M.S.: | University of Bern, Switzerland, Microbiology (1989) |
| Ph.D.: | University of Bern, Switzerland, Immunology (1992) |
Postdoctoral Advisees
Michael Betley, Joseph Castellano, Eva Czirr, Elizabeth Kirby, Benoit Olivier Guillaume Lehallier, Kurt Lucin, Vidhu Mathur, Takeshi Matsui, Jinte Middeldorp
Graduate & Fellowship Program Affiliations
Internet Links
Scientific Focus
Current Research Interests
Our laboratory studies the role of immune and injury responses in neurodegeneration and Alzheimers disease. We seek to understand how immune responses and injury pathways may modulate neurodegeneration and age-related changes in the brain. We study these pathways in vivo and in cell culture using a number of genetic and proteomic tools. We have been particularly interested in the TGF-beta signaling pathway as a major regulator of biological processes and we are developing genetic and pharmacological agents to manipulate this pathway.
Publications
- Colony-stimulating factor 1 receptor (CSF1R) signaling in injured neurons facilitates protection and survival. J Exp Med. 2013; (1): 157-72
- Neural progenitor cells regulate microglia functions and activity. Nat Neurosci. 2012; (11): 1485-7
- The immunology of neurodegeneration. J Clin Invest. 2012; (4): 1156-63
- Modeling of pathological traits in Alzheimer's disease based on systemic extracellular signaling proteome. Mol Cell Proteomics. 2011; (10): M111.008862
- The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature. 2011; (7362): 90-4
- A small molecule p75(NTR) ligand prevents cognitive deficits and neurite degeneration in an Alzheimer's mouse model. Neurobiol Aging. 2013; (8): 2052-63
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