Zev Bryant
Academic Appointments
- Assistant Professor, Bioengineering
- Member, Bio-X
- Assistant Professor (By courtesy), Structural Biology
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 724-3090Alternate Contact Sarah Saya Administrative Associate Email Tel Work (650) 498-6370
Professional Overview
Honors and Awards
- Pew Scholars Award, Pew Charitable Trusts (2009)
- Director's New Innovator Award, NIH (2008)
- Postdoctoral Fellowship, Helen Hay Whitney Foundation (2005)
- Alan Bearden Award, UC, Berkeley (2004)
- Harold M. Weintraub Award, FHCRC (2004)
- Predoctoral Fellowship, Howard Hughes Medical Institute (1999)
Professional Education
| B.Sc.: | University of Washington, Biochemistry (1998) |
| Ph.D.: | UC, Berkeley, Molecular and Cell Biology (2003) |
Graduate & Fellowship Program Affiliations
Internet Links
Scientific Focus
Current Research Interests
Molecular motors lie at the heart of biological processes from DNA replication to vesicle transport. My laboratory seeks to understand the physical mechanisms by which these nanoscale machines convert chemical energy into mechanical work. We use single molecule tracking and manipulation techniques to observe and perturb substeps in the mechanochemical cycles of individual motors. Protein engineering helps us to explore relationships between molecular structures and mechanical functions. Broad topics of current interest include torque generation by DNA-associated ATPases and mechanical adaptations of unconventional myosins.
Publications
- Torque Spectroscopy of DNA: Base-Pair Stability, Boundary Effects, Backbending, and Breathing Dynamics. Phys Rev Lett. 2013; (17): 178103
- ATP binding controls distinct structural transitions of Escherichia coli DNA gyrase in complex with DNA. Nat Struct Mol Biol. 2012; (5): 538-46, S1
- Engineering controllable bidirectional molecular motors based on myosin. Nat Nanotechnol. 2012; (4): 252-6
- Recent developments in single-molecule DNA mechanics. Curr Opin Struct Biol. 2012; (3): 304-12
- Torque measurements reveal sequence-specific cooperative transitions in supercoiled DNA. Proc Natl Acad Sci U S A. 2012; (16): 6106-11
- Detailed tuning of structure and intramolecular communication are dispensable for processive motion of myosin VI. Biophys J. 2011; (2): 430-9
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