Thomas P. Andriacchi
Academic Appointments
- Professor, Mechanical Engineering - Biomechanical Operations
- Professor, Orthopaedic Surgery
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 723-8024Alternate Contact Melanie Cole Administrative Associate Email Tel Work 650 723 8024
Professional Overview
Honors and Awards
- Contributions to Osteoarthritis Research, Arthritis Foindation (2012)
- H.R. Lissner Medal, American Society of Mechanical Engineers (2009)
- Lifetime Achievement Award, San Francisco Bay Area Knee Society (2008)
- Fellow of American Society of Mechanical Engineers, American Society of Mechanical Engineers (2007)
- Borelli Award, American Society of Biomechanics (2004)
- Kappa Delta Award, Orthopedic Research Society (2004)
Graduate & Fellowship Program Affiliations
Internet Links
Industry Relationships
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Scientific Focus
Current Research Interests
The main focus of the research conducted in Professor Andriacchis Biomotion Laboratory is to apply the study of normal and pathological human movement to the evaluation and treatment of musculoskeletal disease and injury. The Laboratory provides unique information on the relationship between the in vivo pathomechanics of human movement and the mechanisms that influence the initiation and progression of musculoskeletal disease and injury. As such, the Laboratory intergrates information from collaborative studies that conduct animal and/or in vitro testing by providing the in vivo perspective on the problem. Specifically, the Laboratory has identified unique ambulatory conditions that are associated with the development of premature osteoarthritis following joint trauma. The Laboratory is using this information as an objective tool to evaluate the efficacy of specific treatments for modifying ambulatory patterns that lead to post-trauma osteoarthritis. Similarly, the association between obesity and premature osteoarthritis is being studied to evaluate the interactions between ambulatory changes , biological changes (from serum biomarkers) and structural changes to cartilage (from MRI) that converge to make obesity the main risk factor for developing osteoarthritis.
This work has had direct translational results producing an inexpensive load modifying intervention in the form of a shoe that has been shown to reduce knee pain in patients with medial compartment osteoarthritis. There is also a major program to develop prevention strategies for reducing the risk for anterior cruciate ligament injury, a common sports injury to the knee. Improved methods for assessing morphological cartilage changes from MR images have been developed and applied to establishing a relationship between mechanical loading during walking and cartilage thickness. Finally, the Laboratory has been a leader in the development of improved methods for the measurement and analysis of human movement. One such improvement is the creation and development of a markerless motion capture system giving the researchers the capacity to analyze human movement without placing markers on the subject.
Publications
- Effect of variable-stiffness walking shoes on knee adduction moment, pain, and function in subjects with medial compartment knee osteoarthritis after 1 year. J Orthop Res. 2012; (4): 514-21
- Osteoarthritis: Probing knee OA as a system responding to a stimulus. Nat Rev Rheumatol. 2012; (7): 371-2
- Differences in tibial rotation during walking in ACL reconstructed and healthy contralateral knees. J Biomech. 2010; (9): 1817-22
- Gait mechanics influence healthy cartilage morphology and osteoarthritis of the knee. J Bone Joint Surg Am. 2009: 95-101
- Knee kinematics, cartilage morphology, and osteoarthritis after ACL injury. Med Sci Sports Exerc. 2008; (2): 215-22
- A framework for the in vivo pathomechanics of osteoarthritis at the knee. Ann Biomed Eng. 2004; (3): 447-57
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