My laboratory research interest focusses on the identification of serum markers for tumor hypoxia and for prognosis in patients with head and neck or lung cancers. I am also conducting a number of clinical trials specifically in patients with these tumors. For head and neck cancer, I am conducting a trial using iressa, chemotherapy and re-irradiation in patients with unresectable recurrent tumors, a trial using Evoxac to improve radiation-induced xerostomia in previously treated patients, and 2 trials on serum markers for hypoxia and treatment outcomes. For lung cancer patients, I am conducting a phase II trial with Tirapazamine and conventional treatment in patients with limited stage small cell lung cancers through the Southwest Oncology Group and a trial on using stereotactic radiosurgical ablation for small unresectable or metastatic lung tumors.

• Lee L, Le QT, Xing L "Retrospective IMRT Dose Reconstruction Based on Cone-Beam CT and MLC Log-File." Int J Radiat Oncol Biol Phys 2008; 70: 2: 634-44 More
• Le QT, Koong A, Lieskovsky YY, Narasimhan B, Graves E, Pinto H, Brown JM, Spielman D "In vivo(1)H Magnetic Resonance Spectroscopy of Lactate in Patients with Stage IV Head-and-Neck Squamous Cell Carcinoma." Int J Radiat Oncol Biol Phys 2008; More
• Kim GY, Pawlicki T, Le QT, Luxton G "Linac-based on-board imaging feasibility and the dosimetric consequences of head roll in head-and-neck IMRT plans." Med Dosim 2008; 33: 1: 93-9 More
• Quon A, Fischbein NJ, McDougall IR, Le QT, Loo BW, Pinto H, Kaplan MJ "Clinical Role of 18F-FDG PET/CT in the Management of Squamous Cell Carcinoma of the Head and Neck and Thyroid Carcinoma." J Nucl Med 2007; 48: 1_suppl: 58S-67S More
• Le QT, Kong C, Lavori PW, O'byrne K, Erler JT, Huang X, Chen Y, Cao H, Tibshirani R, Denko N, Giaccia AJ, Koong AC "Expression and Prognostic Significance of a Panel of Tissue Hypoxia Markers in Head-and-Neck Squamous Cell Carcinomas." Int J Radiat Oncol Biol Phys 2007; 69: 1: 167-75 More