Philip Beachy
Academic Appointments
- Professor, Biochemistry
- Member, Bio-X
- Professor, Developmental Biology
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 723-4521Alternate Contact Judith Mathews Administrative Assistant Email Tel Work 650-736-8530
Professional Overview
Administrative Appointments
- Member, Institute for Stem Cell Biology and Regenerative Medicine (2006 - present)
- Member, Stanford Cancer Center (2006 - present)
Honors and Awards
- Keio Medical Science Prize, Keio University, Japan (2011)
- March of Dimes Prize in Developmental Biology, March of Dimes Birth Defects Foundation (2008)
- Fellow, American Academy of Arts and Sciences (2003)
- Member, National Academy of Sciences (2002)
- National Academy of Sciences Award in Molecular Biology, National Academy of Sciences (1998)
- Outstanding Young Scientist Award, Maryland Academy of Sciences (1997)
Professional Education
| Ph.D.: | Stanford University, Biochemistry (1986) |
| B.S.: | Goshen College, Goshen, Indiana, Natural Sciences (1979) |
Graduate & Fellowship Program Affiliations
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information
Scientific Focus
Current Research Interests
My lab studies the function of Hedgehog proteins and other extracellular signals in morphogenesis (pattern formation) and in injury repair and regeneration (pattern maintenance). We study how the distribution of such signals is regulated in tissues, how cells perceive and respond to distinct concentrations of signals, and how such signaling pathways arose in evolution. We also study the normal roles of such signals in stem-cell physiology and their abnormal roles in the formation and expansion of cancer stem cells.
Publications
- Itraconazole and arsenic trioxide inhibit Hedgehog pathway activation and tumor growth associated with acquired resistance to smoothened antagonists. Cancer Cell. 2013; (1): 23-34
- Hedgehog-responsive candidate cell of origin for diffuse intrinsic pontine glioma. Proc Natl Acad Sci U S A. 2011; (11): 4453-8
- Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder. Nature. 2011; (7341): 110-4
- Arsenic antagonizes the Hedgehog pathway by preventing ciliary accumulation and reducing stability of the Gli2 transcriptional effector. Proc Natl Acad Sci U S A. 2010; (30): 13432-7
- Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response. Proc Natl Acad Sci U S A. 2010; (13): 5869-74
- Genetic and biochemical definition of the Hedgehog receptor. Genes Dev. 2010; (1): 57-71
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