Katrin Andreasson
Academic Appointments
- Associate Professor - Med Center Line, Neurology & Neurological Sciences
- Member, Bio-X
Key Documents
Contact Information
- Academic Offices
Alternate Contact Jackie Bautista Administrative Associate Email Tel Work 650 498 5855
Professional Overview
Honors and Awards
- Pfizer/AFAR Innovations in Aging Research Award, American Federation for Aging Research (07/05)
- Paul Beeson Physician Faculty Scholars in Aging Award, American Federation for Aging Research (07/2001)
Graduate & Fellowship Program Affiliations
Internet Links
Scientific Focus
Current Research Interests
We are interested in understanding the basic mechanisms by which neurons die in stroke and in neurodegenerative disease, including Alzheimers disease, Parkinsons disease, and amyotrophic lateral sclerosis (ALS). Our focus is on the cyclooxygenase-2 (COX-2) pathway, which has been found to play a critical role in promoting neuronal death in a number of models of neurological disease, including stroke, Parkinsons disease, amyotrophic lateral sclerosis, and Alzheimers disease. We are examining the function of downstream prostaglandin receptor signaling pathways, focusing on the functions of prostaglandin receptors in glutamate toxicity, ischemia, and neuroinflammation. Using a combination of in vitro and in vivo genetic and pharmacological strategies, we are finding that specific prostaglandin receptor signaling pathways impact dramatically on disease progression in models of both acute and chronic neurodegeneration. The long-term goal of our research is to understand the contribution of prostaglandin signaling to neuronal injury in a wide array of neurological diseases and to develop therapeutic strategies targeting these pathways in human disease.
Publications
- Inflammatory prostaglandin E2 signaling in a mouse model of Alzheimer disease. Ann Neurol. 2012; (5): 788-98
- Reversal of paralysis and reduced inflammation from peripheral administration of β-amyloid in TH1 and TH17 versions of experimental autoimmune encephalomyelitis. Sci Transl Med. 2012; (145): 145ra105
- Signaling via the prostaglandin E₂ receptor EP4 exerts neuronal and vascular protection in a mouse model of cerebral ischemia. J Clin Invest. 2011; (11): 4362-71
- Emerging roles of PGE2 receptors in models of neurological disease. Prostaglandins Other Lipid Mediat. 2010; (3-4): 104-12
- The prostaglandin E2 E-prostanoid 4 receptor exerts anti-inflammatory effects in brain innate immunity. J Immunol. 2010; (12): 7207-18
- The prostaglandin E2 EP2 receptor accelerates disease progression and inflammation in a model of amyotrophic lateral sclerosis. Ann Neurol. 2008; (3): 304-14
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