Joshua Elias
Academic Appointments
- Assistant Professor, Chemical and Systems Biology
- Member, Stanford Cancer Institute
Key Documents
Contact Information
- Academic Offices
Personal Information EmailAdministrative Contact Sarah Alexander Administrative Assistant Email Tel Work 650-724-2971
Professional Overview
Honors and Awards
- Innovation Award, Damon Runyon Cancer Research Foundation (1/1/11-12/31/13)
Professional Education
| Ph.D.: | Harvard University, Cell Biology (2006) |
| B.S.: | Cornell University, Biology, Genetics (1998) |
Graduate & Fellowship Program Affiliations
Internet Links
Scientific Focus
Current Research Interests
The Elias Lab seeks to develop and apply methods for large scale proteome characterization to solve fundamental problems in cell biology and disease. The growing field of proteomics has the lofty goal of characterizing the proteins in any isolated complex, subcellular compartment, cultured cell line or tissue. We use mass spectrometry-based approaches which can do more than simply determining the identity of a protein isolated in a polyacrylamide gel -- rapidly advancing technologies are allowing us to measure dynamic changes in protein abundances, post-translational modification states, splice isoforms, interaction partners, and localization across multiple cell states. The combination of liquid chromatography with tandem mass spectrometry (LC-MS/MS) has emerged as the most robust technology for making proteome-scale discoveries. Although the tools of proteomics have greatly advanced in recent years, many challenges lie ahead. Our lab focuses on developing new methods in protein fractionation, instrumentation, and data analysis to meet these challenges, and then applies them to studying important biomedical paradigms, including cancer, aging, and stem cell biology.
Publications
- A function for cyclin D1 in DNA repair uncovered by protein interactome analyses in human cancers. Nature. 2011; (7350): 230-4
- The dynamic state of protein turnover: It's about time. Trends Cell Biol. 2011; (5): 293-303
- The phosphoproteomes of Plasmodium falciparum and Toxoplasma gondii reveal unusual adaptations within and beyond the parasites' boundaries. Cell Host Microbe. 2011; (4): 410-9
- A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010; (7): 1174-89
- Target-decoy search strategy for increased confidence in large-scale protein identifications by mass spectrometry. Nat Methods. 2007; (3): 207-14
- Comparative evaluation of mass spectrometry platforms used in large-scale proteomics investigations. Nat Methods. 2005; (9): 667-75
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