Interleukin-12 is a Th1 cytokine. It is important in the cell mediated immune response. We are investigating its role as an anti-tumor cytokine to augment the immune response against cancer. We are planning a human trial.

• Norton JA, Ham CM, Dam JV, Jeffrey RB, Longacre TA, Huntsman DG, Chun N, Kurian AW, Ford JM "CDH1 Truncating Mutations in the E-Cadherin Gene: An Indication for Total Gastrectomy to Treat Hereditary Diffuse Gastric Cancer." Ann Surg 2007; 245: 6: 873-879 More
• Cupp JS, Koong AC, Fisher GA, Norton JA, Goodman KA "Tissue Effects after Stereotactic Body Radiotherapy using Cyberknife for Patients with Abdominal Malignancies." Clin Oncol (R Coll Radiol) 2007; More
• Norton JA, Li M, Lee NC, Tsung K "Inhibition of Host Signal Transducer and Activator of Transcription Factor 6 Results in Cure With Cyclophosphamide and Interleukin 12 Immunotherapy." Ann Surg Oncol 2006; More
• Norton JA, Fang TD, Jensen RT "Surgery for Gastrinoma and Insulinoma in Multiple Endocrine Neoplasia Type 1." J Natl Compr Canc Netw 2006; 4: 2: 148-153 More
• Tsung K, Norton JA "Lessons from Coley's Toxin." Surg Oncol 2006; More