Our research centers on the signal transduction circuits that trigger the entry into mitotic and meoitic M-phase, the progression through these phases, and the exit from M-phase to interphase.

Some of our work is aimed at identifying as-yet unidentified components of these regulatory circuits. The rest of our work is aimed at understanding the systems level logic of these circuits--how cells build reliable switches, oscillators, and response networks out of imperfect components.

• PRD-1-Day Band Performance, Opening Ceremony, Guangzhou Triennial, Guangzhou, China More 

• Ferrell JE, "Feedback regulation of opposing enzymes generates robust, all-or-none bistable responses." Curr Biol 2008; 18: 6: R244-5 More
• Hendrickson DG, Hogan DJ, Herschlag D, Ferrell JE, Brown PO "Systematic Identification of mRNAs Recruited to Argonaute 2 by Specific microRNAs and Corresponding Changes in Transcript Abundance." PLoS ONE 2008; 3: 5: e2126 More
• Tsai TY, Choi YS, Ma W, Pomerening JR, Tang C, Ferrell JE "Robust, Tunable Biological Oscillations from Interlinked Positive and Negative Feedback Loops." Science 2008; 321: 5885: 126-129 More
• Pomerening JR, Ubersax JA, Ferrell JE "Rapid Cycling and Precocious Termination of G1 Phase in Cells Expressing CDK1AF." Mol Biol Cell 2008; More
• Gong D, Pomerening JR, Myers JW, Gustavsson C, Jones JT, Hahn AT, Meyer T, Ferrell JE "Cyclin A2 regulates nuclear-envelope breakdown and the nuclear accumulation of cyclin b1." Curr Biol 2007; 17: 1: 85-91 More