Glenn Rosen

Clinical Focus

• Pulmonary Disease
• Pulmonology (Lung) and Critical Care

Administrative Appointments

• Director, Fellowship Program, Pulmonary and Critical Care Medicine (2004 - present)
• Division Co-Chief, Pulmonary and Critical Care Medicine (2004 - present)

Honors and Awards

• Award for Lung Cancer Research, Jack Elway Memorial Fund (2002-2003)
• Institutional American Cancer Society Award, Stanford University (1994-1995)
• Research Fellowship Award, American Lung Association (1990)
• Magna Cum Laude, University of Pennsylvania (1979)
• Phi Betta Kappa, University of Pennsylvania (1979)

Professional Education

Postdoctoral Advisees

Monica Bhargava , Joe Hsu , Vincent Liu , Viswam Nair , Yon Sung

Graduate & Fellowship Program Affiliations

• Medicine

Community & International Work

• Member, American Cancer Society Cell Cycle & Growth Control Advisory Committee 
• Review Panel Member - NIH Special Emphasis Panel 

Web Site Links

• Pulmonary/Critical Care Research Website

Research Interests

Our laboratory examines apoptotic and cell cycle pathways in the lung with a focus on fibrotic lung disease and lung cancer. We have identified a novel regulator of cell cycle progression in immune cells. We are also studying TGF beta signaling in lung cells which regulates myofibroblast differentiation and epithelia mesenchymal transition. Our laboratory is also collaborating with the laboratory of Dr. Irving Weissman to isolate and characterize lung cancer stem cells, and we are collaborating with a local biotechnology company on a proteomic analysis of lung cancer. We also are involved in trials of novel therapeutics for patients with pulmonary fibrosis.

Clinical Trials

• Microarray Analysis of Gene Expression and Identification of Progenitor Cells in Lung Carcinoma Recruiting

Publications

• Nicotine induces resistance to chemotherapy by modulating mitochondrial signaling in lung cancer. Zhang J, Kamdar O, Le W, Rosen GD, Upadhyay D. Am J Respir Cell Mol Biol. 2009; 40 (2): 135-46
• Air pollution induces enhanced mitochondrial oxidative stress in cystic fibrosis airway epithelium. Kamdar O, Le W, Zhang J, Ghio AJ, Rosen GD, Upadhyay D. FEBS Lett. 2008; 582 (25-26): 3601-6
• Ambient particulate matter induces alveolar epithelial cell cycle arrest: role of G1 cyclins. Zhang J, Ghio AJ, Gao M, Wei K, Rosen GD, Upadhyay D. FEBS Lett. 2007; 581 (27): 5315-20
• Bim mediates mitochondria-regulated particulate matter-induced apoptosis in alveolar epithelial cells. Zhang J, Ghio AJ, Chang W, Kamdar O, Rosen GD, Upadhyay D. FEBS Lett. 2007; 581 (22): 4148-52
• Fibroblast growth factor-10 prevents H2O2-induced cell cycle arrest by regulation of G1 cyclins and cyclin dependent kinases. Upadhyay D, Chang W, Wei K, Gao M, Rosen GD. FEBS Lett. 2007; 581 (2): 248-52