Gavin Sherlock
Academic Appointments
- Associate Professor, Genetics
- Member, Stanford Cancer Institute
Key Documents
Contact Information
- Academic Offices
Personal Information Email
Professional Overview
Honors and Awards
- Army Breast Cancer Research Fellowship, Department of Defence (1997-1998)
- Cold Spring Harbor Fellowship, Cold Spring Harbor Laboratory (1996-1997)
- Prize Studentship, The Wellcome Trust (1991-1994)
- John Buckley Entrance Scholarship for Science, Manchester University (1988-1991)
Professional Education
| B.Sc.: | Manchester University, Genetics (1991) |
| Ph.D.: | Manchester University, Molecular Biology (1994) |
Graduate & Fellowship Program Affiliations
Internet Links
Scientific Focus
Current Research Interests
1. Evolution and the Adpative Landscape
When yeast are evolved under various selective pressures in a chemostat, mutations that arise and provide an adaptive advantage will expand within the population. We are using high throughput sequencing to determine the identity of such mutations, as well as to understand the dynamics of the mutations within the populations, and the interactions between the mutations (such as epistasis).
2. Genome Annotation by Transcriptome Sequencing
The set of genes in a sequenced genome has typically been defined using various prediction criteria (such as ORFs capable of encoding a protein > 100 amino acids), coupled with experimental data, such as transposon mutagenesis and EST sequencing. The availability of high throughput sequencing now allows full transcriptome sequencing to better annotate the transcribed regions of the genome, and we are applying this to various yeasts.
Publications
- Analysis of the Saccharomyces cerevisiae pan-genome reveals a pool of copy number variants distributed in diverse yeast strains from differing industrial environments. Genome Res. 2012; (5): 908-24
- DNA methylation profiling reveals novel biomarkers and important roles for DNA methyltransferases in prostate cancer. Genome Res. 2011; (7): 1017-27
- Hunger artists: yeast adapted to carbon limitation show trade-offs under carbon sufficiency. PLoS Genet. 2011; (8): e1002202
- Reciprocal sign epistasis between frequently experimentally evolved adaptive mutations causes a rugged fitness landscape. PLoS Genet. 2011; (4): e1002056
- A genome-wide analysis reveals no nuclear dobzhansky-muller pairs of determinants of speciation between S. cerevisiae and S. paradoxus, but suggests more complex incompatibilities. PLoS Genet. 2010; (7): e1001038
- Bulk segregant analysis by high-throughput sequencing reveals a novel xylose utilization gene from Saccharomyces cerevisiae. PLoS Genet. 2010; (5): e1000942
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