Dorsey Bass
Academic Appointments
- Associate Professor - Med Center Line, Pediatrics - Gastroenterology
Key Documents
Contact Information
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Clinical Offices
Pediatric Gastroenterology 730 Welch Rd, 2nd Floor Palo Alto, CA 94304 Tel Work (650) 721-2250 Fax (650) 498-5608Practices at Stanford Hospital and Clinics and Lucile Packard Children's Hospital
- Academic Offices
Personal Information EmailNot for medical emergencies or patient use
Professional Overview
Clinical Focus
- Gastroenterology/Nutrition/Hepatology, Pediatric
- Pediatric Gastroenterology
Professional Education
| Residency: | Boston City Hospital MA (1982) |
| Board Certification: | Pediatrics, American Board of Pediatrics (1987) |
| Fellowship: | Stanford University School of Medicine CA (1990) |
| Fellowship: | Massachusetts General Hospital MA (1986) |
| Internship: | Boston City Hospital MA (1979) |
| Medical Education: | Vanderbilt University Medical Center TN (1979) |
Graduate & Fellowship Program Affiliations
Scientific Focus
Current Research Interests
Viral gastroenteritis is the single most important cause of diarrhea in infancy world-wide and accounts for enormous morbidity and mortality in children in both the developing and developed worlds. Our laboratory is interested in the pathogenesis of viral gastroenteritis, specifically in intestinal factors which are critical to the outcome of rotavirus infection which range from asymptomatic viral shedding to severe clinical disease. Previous observations have shown that rotavirus has both a narrowly defined tissue tropism, essentially mature enterocytes of the intestinal villus tip, and a fairly narrow host range restriction, causing disease mainly in suckling animals and usually only with viral strains derived from the same host species. We believe that local gastrointestinal factors determine the outcome of rotavirus infection. Specific studies include:
1) Cell receptors for rotavirus are being identified and characterized by a variety of biochemical and immunological approaches.
2) Rotavirus penetration of target cell membranes. Work from our lab has shown that this is a critical step in determing host cell susceptibility to the virus.
3) Role of enteric secretions on rotavirus pathogeneis. Rotavirus requires exogenous trypsin for replication. We are studying the effects of gastrointestinal proteases and acid secretion on rotavirus pathogeneis in vitro and in vivo.
4) Role of intestinal mucins as a defense mechanism against rotavirus.
5) Mucosal immunity and protection from enteric viral pathogens.
Publications
- Cost-effectiveness of Universal Serologic Screening to Prevent Nontraumatic Hip and Vertebral Fractures in Patients With Celiac Disease. Clin Gastroenterol Hepatol. 2013; (6): 645-53
- Cost-effectiveness of early colectomy with ileal pouch-anal anastamosis versus standard medical therapy in severe ulcerative colitis. Ann Surg. 2012; (1): 117-24
- Acute liver failure and aplastic anemia in an 11-year-old girl. Dig Dis Sci. 2011; (8): 2237-40
- Cost-effectiveness analysis of adjunct VSL#3 therapy versus standard medical therapy in pediatric ulcerative colitis. J Pediatr Gastroenterol Nutr. 2011; (5): 489-96
- Immunophenotyping of peripheral eosinophils demonstrates activation in eosinophilic esophagitis. J Pediatr Gastroenterol Nutr. 2011; (1): 40-7
- Inflammatory bowel disease-attributable costs and cost-effective strategies in the United States: a review. Inflamm Bowel Dis. 2011; (7): 1603-9
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