Amato J. Giaccia
Academic Appointments
- Professor, Radiation Oncology - Radiation and Cancer Biology
- Member, Stanford Cancer Institute
- Professor (By courtesy), Obstetrics & Gynecology
- Professor (By courtesy), Surgery
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 723-7366Alternate Contact Sharon Clarke Administrative Associate Email Tel Work 650.723.7311
Professional Overview
Honors and Awards
- MERIT Award, NIH (2010)
- Jack, Lulu and Sam Willson Endowed Professor of Cancer Biology, Stanford University (2006)
- Virginia Logan Lecture, Thomas Jefferson University (2003)
- John Yuhas Award (Excellence in Radiation Oncology, University of Pennsylvania), University of Pennsylvania (2000)
- Michael Fry Research Awardee of the Radiation Research Society, Radiation Research Society (1997)
- Howard Hughes Junior Faculty Award, Stanford University (1996)
Postdoctoral Advisees
Laura Castellini, Anh Diep, Elizabeth Finger, Katherine Fuh, Edward LaGory, Yu Miao, Eui Jung Moon, Colleen Wu
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information
Scientific Focus
Current Research Interests
During the last five years, we have identified several small molecules that acted to kill VHL deficient renal cancer cells through a synthetic lethal screening approach. We published on one of the molecules (Cancer Cell 14: 90, 2008) that killed VHL deficient tumor and are performing screens to identify new therapeutics against other targets. Another major interest of my laboratory is in identifying hypoxia-induced genes involved in invasion and metastases. We have identified and characterized several genes that are induced by hypoxia and promote metastases in breast, ovarian, renal and head and neck cancer (Nature 440:1222, 2006, Cancer Cell 15:35, 2009) and are developing therapeutics against them. My group is also investigating how hypoxia regulates gene expression epigenetically through the regulation of histone demethylases and microRNAs.
Publications
- A low-carb diet kills tumor cells with a mutant p53 tumor suppressor gene: the Atkins diet suppresses tumor growth. Cell Cycle. 2013; (5): 718-9
- CTGF is a therapeutic target for metastatic melanoma. Oncogene. 2013
- Blood and bones: osteoblastic HIF signaling regulates erythropoiesis. Cell Cycle. 2012; (12): 2221-2
- Global alteration in gene expression profiles of deciduas from women with idiopathic recurrent pregnancy loss. Mol Hum Reprod. 2012; (9): 442-50
- Prognostic and predictive significance of plasma HGF and IL-8 in a phase III trial of chemoradiation with or without tirapazamine in locoregionally advanced head and neck cancer. Clin Cancer Res. 2012; (6): 1798-807
- Prognostic significance of plasma osteopontin in patients with locoregionally advanced head and neck squamous cell carcinoma treated on TROG 02.02 phase III trial. Clin Cancer Res. 2012; (1): 301-7
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