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Xiaoyuan (Shawn) Chen
Email:
Phone:(650) 725-0950 Profile: http://med.stanford.edu/profiles/Xiaoyuan_Chen/
Alternate Contact: Academic Appointments
Appointment
Organization
Associate Professor (Research)
Member
Member
Radiology ;
Biophysics ;
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Curriculum Vitae PDF
Honors & Awards
Title
Organization
Date(s)
Best Basic Science Awards
SNM Annual Meetings
2006, 2007, 2008
First place award
SNM’s Molecular Imaging Center of Excellence
2008
Administrative Appointments
Title
Organization
Start Year
End Year
Editorial Board
J Nucl Med
2008
-
Editorial Board
Bioconjugate Chemistry
2008
-
Editorial Board
Molecular Imaging
2008
-
Editorial Board
Molecular Imaging and Biology
2008
-
Editorial Board
The Open Medical Imaging Journal
2007
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9 appointments: view full list
Postdoctoral Advisees
Qizhen Cao,
Shuanglong Liu,
Gang Niu,
Hui Wang,
Jin Xie,
Yongjun Yan
Web Site Links
Research/Lab website:
Molecular Imaging Probe Laboratory (MIPL)
Research Interests
We are interested in developing and validating novel molecular imaging probes (nanoparticles, antibodies, proteins, peptides and small organic molecules) for the visualization and quantification of molecular targets that are aberrantly expressed during tumor growth, angiogenesis and metastasis. We are trying to combine both anatomical and molecular imaging techniques to pinpoint molecular and functional information related to tumor growth and dissemination, and monitor specific molecular therapeutic efficacy. We are currently working closely with two important angiogenesis targets: integrin alpha(v)beta(3) and vascular endothelial growth factor receptor subtype-2 (VEGFR-2). Integrins expressed on endothelial cells modulate cell migration and survival during angiogenesis. Integrins expressed on carcinoma cells potentiate metastasis by facilitating invasion and movement across blood vessels. In several malignancies, tumor expression of integrin alpha(v)beta(3) correlates well with tumor progression. VEGF is a key regulator of tumor angiogenesis and is the most potent endothelial cell mitogen. Binding of VEGF to its receptor on the endothelial cell membrane stimulates the VEGF signaling pathway. VEGFR-2 (KDR/Flk-1) is the primary VEGF receptor on endothelial cells. Specific projects include nanoplatform-based molecular imaging, multimodality imaging of angiogenesis and metastasis, as well as targeted delivery of gene, chemo, and radiotherapeutics.
Publications
- Cai W, Chen X "Preparation of peptide-conjugated quantum dots for tumor vasculature-targeted imaging." Nat Protoc 2008; 3: 1: 89-96 More »
- Willmann JK, Paulmurugan R, Chen K, Gheysens O, Rodriguez-Porcel M, Lutz AM, Chen IY, Chen X, Gambhir SS "US Imaging of Tumor Angiogenesis with Microbubbles Targeted to Vascular Endothelial Growth Factor Receptor Type 2 in Mice." Radiology 2008; More »
- Liu Z, Davis C, Cai W, He L, Chen X, Dai H "Circulation and long-term fate of functionalized, biocompatible single-walled carbon nanotubes in mice probed by Raman spectroscopy." Proc Natl Acad Sci U S A 2008; More »
- Willmann JK, Chen K, Wang H, Paulmurugan R, Rollins M, Cai W, Wang DS, Chen IY, Gheysens O, Rodriguez-Porcel M, Chen X, Gambhir SS "Monitoring of the Biological Response to Murine Hindlimb Ischemia With 64Cu-Labeled Vascular Endothelial Growth Factor-121 Positron Emission Tomography." Circulation 2008; More »
- Liu Z, Cai W, He L, Nakayama N, Sun X, Chen X, Dai H "In Vivo Biodistribution and Highly Efficient Tumor Targeting of Carbon Nanotubes in Mice" Nat Nanotechnol 2007; 2: 1: 47-52 More »
124 publications: view full list
