Jennifer R. Cochran
Academic Appointments
- Associate Professor, Bioengineering
- Member, Child Health Research Institute
- Member, Stanford Cancer Institute
- Member, Bio-X
- Associate Professor (By courtesy), Chemical Engineering
Key Documents
Contact Information
- Academic Offices
Personal Information EmailAlternate Contact Carlos Cabezas Administrative Assistant Email Tel Work (650) 498-6135
Professional Overview
Honors and Awards
- Martin D. Abeloff Scholar Award, V Foundation (2008)
- Hellman Faculty Scholar Award, Hellman Foundation (2008)
- McCormick Award, McCormick Foundation (2007)
- Mallinckrodt Faculty Scholar Award, Edward Mallinckrodt Jr. Foundation (2007)
- Kimmel Scholars Award, Sidney Kimmel Foundation (2007)
- Translational Partnership Award, Wallace H. Coulter Foundation (2006, 2007)
Professional Education
| Postdoctoral Fellow: | MIT, Biological Engineering |
| Ph. D.: | MIT, Biological Chemistry (2001) |
| B.S.: | University of Delaware, Biochemistry (1995) |
Graduate & Fellowship Program Affiliations
Internet Links
Industry Relationships
Stanford is committed to ethical and transparent interactions with our industrial and other commercial partners. It is our policy to disclose payments (exclusive of travel support) from, and/or equity in, companies or other commercial entities to Stanford faculty of $5,000 or more in total value, as well as any equity in a privately held company, when the faculty member also has institutional responsibilities related to his or her interactions with the company. View Full Information
Scientific Focus
Current Research Interests
The Cochran laboratory uses interdisciplinary approaches in chemistry, engineering, and biophysics to study complex biological systems. Our main goals are to develop new technologies for basic science and biomedical applications. Clinical applications of our research involves wound healing, biomimetic corneas, cardiac tissue regeneration, and cancer imaging and therapy. Our research is driven by the philosophy that in order to control physiological processes it is necessary to understand the molecular mechanisms that drive these processes. We are interested in elucidating molecular details of receptor-mediated cell signaling events; at the same time developing protein and peptide-based tools that will allow us to manipulate cellular processes on a molecular level. For biomedical applications, we are combining rational design and combinatorial methods to create designer protein therapeutics and diagnostic agents. One such example is highlighted in a recent press release: http://med.stanford.edu/ism/2011/august/cochran.html.
Publications
- Beyond antibodies: using biological principles to guide the development of next-generation protein therapeutics. Curr Opin Biotechnol. 2013
- Antagonistic VEGF variants engineered to simultaneously bind to and inhibit VEGFR2 and alphavbeta3 integrin. Proc Natl Acad Sci U S A. 2011; (34): 14067-72
- Engineered epidermal growth factor mutants with faster binding on-rates correlate with enhanced receptor activation. FEBS Lett. 2011; (8): 1135-9
- Engineering hepatocyte growth factor fragments with high stability and activity as Met receptor agonists and antagonists. Proc Natl Acad Sci U S A. 2011; (32): 13035-40
- Engineered proteins pull double duty. Sci Transl Med. 2010; (17): 17ps5
- Engineered cystine-knot peptides that bind alpha(v)beta(3) integrin with antibody-like affinities. J Mol Biol. 2009; (4): 1064-75
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