Merritt Maduke

Publications

• A designed inhibitor of a CLC antiporter blocks function through a unique binding mode. Howery AE, Elvington S, Abraham SJ, Choi KH, Dworschak-Simpson S, Phillips S, Ryan CM, Sanford RL, Almqvist J, Tran K, Chew TA, Zachariae U, Andersen OS, Whitelegge J, Matulef K, Du Bois J, Maduke MC. Chem Biol. 2012; 19 (11): 1460-70
• Biochemistry to the rescue: a ClC-2 auxiliary subunit provides a tangible link to leukodystrophy. Maduke MC, Reimer RJ. Neuron. 2012; 73 (5): 855-7
• Review. Proton-coupled gating in chloride channels. Lísal J, Maduke M. Philos Trans R Soc Lond B Biol Sci. 2009; 364 (1514): 181-7
• Substrate-driven conformational changes in ClC-ec1 observed by fluorine NMR. Elvington SM, Liu CW, Maduke MC. EMBO J. 2009; 28 (20): 3090-102
• Thinking outside the crystal: complementary approaches for examining transporter conformational change. Elvington SM, Maduke M. Channels (Austin). 2008 Sep-Oct; 2 (5): 373-9
• A cytoplasmic domain mutation in ClC-Kb affects long-distance communication across the membrane. Martinez GQ, Maduke M. PLoS One. 2008; 3 (7): e2746
• Discovery of potent CLC chloride channel inhibitors. Matulef K, Howery AE, Tan L, Kobertz WR, Du Bois J, Maduke M. ACS Chem Biol. 2008; 3 (7): 419-28
• The ClC-0 chloride channel is a 'broken' Cl-/H+ antiporter. Lísal J, Maduke M. Nat Struct Mol Biol. 2008; 15 (8): 805-10
• The CLC 'chloride channel' family: revelations from prokaryotes. Matulef K, Maduke M. Mol Membr Biol. 2007 Sep-Dec; 24 (5-6): 342-50
• The mechanism of fast-gate opening in ClC-0. Engh AM, Faraldo-Gómez JD, Maduke M. J Gen Physiol. 2007; 130 (4): 335-49
• The role of a conserved lysine in chloride- and voltage-dependent ClC-0 fast gating. Engh AM, Faraldo-Gómez JD, Maduke M. J Gen Physiol. 2007; 130 (4): 351-63
• Cysteine accessibility in ClC-0 supports conservation of the ClC intracellular vestibule. Engh AM, Maduke M. J Gen Physiol. 2005; 125 (6): 601-17
• Side-dependent inhibition of a prokaryotic ClC by DIDS. Matulef K, Maduke M. Biophys J. 2005; 89 (3): 1721-30
• The poststructural festivities begin. Maduke M, Mindell JA. Neuron. 2003; 38 (1): 1-3
• Projection structure of a ClC-type chloride channel at 6.5 A resolution. Mindell JA, Maduke M, Miller C, Grigorieff N. Nature. 2001; 409 (6817): 219-23
• A decade of CLC chloride channels: structure, mechanism, and many unsettled questions. Maduke M, Miller C, Mindell JA. Annu Rev Biophys Biomol Struct. 2000: 29 411-38
• High-level expression, functional reconstitution, and quaternary structure of a prokaryotic ClC-type chloride channel. Maduke M, Pheasant DJ, Miller C. J Gen Physiol. 1999; 114 (5): 713-22
• Formation of CLC-0 chloride channels from separated transmembrane and cytoplasmic domains. Maduke M, Williams C, Miller C. Biochemistry. 1998; 37 (5): 1315-21
• Import of a mitochondrial presequence into P. denitrificans. Insight into the evolution of protein transport. Roise D, Maduke M. FEBS Lett. 1994; 337 (1): 9-13
• Import of a mitochondrial presequence into protein-free phospholipid vesicles. Maduke M, Roise D. Science. 1993; 260 (5106): 364-7