Pehr Harbury

Postdoctoral Advisees

Casey Krusemark

Research Interests

Our lab engineers proteins and small-molecule drugs at atomic resolution through a combination of structural calculations and combinatorial library synthesis. Our goal is to elucidate predictive principles by which novel shapes and catalytic properties can be conferred accurately on designed polypeptides.

Publications

• Remeasuring the double helix. Mathew-Fenn RS, Das R, Harbury PA. Science. 2008; 322 (5900): 446-9
• A molecular ruler for measuring quantitative distance distributions. Mathew-Fenn RS, Das R, Silverman JA, Walker PA, Harbury PA. PLoS One. 2008; 3 (10): e3229
• Design of protein-ligand binding based on the molecular-mechanics energy model. Boas FE, Harbury PB. J Mol Biol. 2008; 380 (2): 415-24
• Potential energy functions for protein design. Boas FE, Harbury PB. Curr Opin Struct Biol. 2007; 17 (2): 199-204
• Chemical evolution as a tool for molecular discovery. Wrenn SJ, Harbury PB. Annu Rev Biochem. 2007: 76 331-49