 |
|
|
Judith FrydmanAcademic Appointments
Appointment
Organization
Associate Professor
Member
Member
|
Research Interests
The long term goal of our research is to understand how proteins fold in living cells. Recent findings indicating that defective protein folding is the molecular basis of many diseases, including some types of cancer, Alzheimer's Disease and Huntington Disease, underscore the importance of understanding the mechanisms of folding and quality control in vivo My lab uses a multi=disciplinary approach to address fundamental questions about molecular chaperones, protein folding and degradation.
Publications
- Geller R, Vignuzzi M, Andino R, Frydman J "Evolutionary constraints on chaperone-mediated folding provide an antiviral approach refractory to development of drug resistance." Genes Dev 2007; 21: 2: 195-205 More »
- Reissmann S, Parnot C, Booth CR, Chiu W, Frydman J "Essential function of the built-in lid in the allosteric regulation of eukaryotic and archaeal chaperonins." Nat Struct Mol Biol 2007; 14: 5: 432-440 More »
- McClellan AJ, Xia Y, Deutschbauer AM, Davis RW, Gerstein M, Frydman J "Diverse cellular functions of the hsp90 molecular chaperone uncovered using systems approaches." Cell 2007; 131: 1: 121-35 More »
- Albanèse V, Yam AY, Baughman J, Parnot C, Frydman J "Systems analyses reveal two chaperone networks with distinct functions in eukaryotic cells." Cell 2006; 124: 1: 75-88 More »
- Miller EJ, Meyer AS, Frydman J "Modeling of possible subunit arrangements in the eukaryotic chaperonin TRiC." Protein Sci 2006; More »
36 publications: view full list
