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Joseph (Jody) Puglisi
Profile: http://med.stanford.edu/profiles/Joseph_Puglisi/
Contact: Academic Appointments
Appointment
Organization
Professor
Member
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Curriculum Vitae PDF
Honors & Awards
Title
Organization
Date(s)
Alfred P. Sloan Research Fellow
Alfred P. Sloan Research Foundation
1997
David and Lucille Packard Fellow
David and Lucille Packard Fellowship in Science and Engineering
1994-99
Teacher Scholar
Camille and Henry Dreyfus Teacher Scholar Award
1993
Administrative Appointments
Title
Organization
Start Year
End Year
Chair, Provost's Advisory Board for Postdoctoral Affairs
Stanford University
2005
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Chair, Dept of Structural Biology
Stanford University School of Medicine
2004
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Senior Editor
Structure
2003
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Director, Int'l School of Biological Magnetic Resonance
EMFCSC, Erice, Italy
2003
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Member
NIH BBCA Study Section
2003
2007
8 appointments: view full list
Professional Education
Degree
Awarding Institution
Field of Study
Year of Graduation
Ph.D.
Univ of California, Berkeley
Biophysical Chemistry
1989
B.A.
The Johns Hopkins University
Chemistry
1984
Postdoctoral Advisees
Alexey Nikolayevich Petrov
Web Site Links
Research/Lab website:
Puglisi Lab Homepage
Research Interests
The Puglisi group investigates the role of RNA in cellular processes and disease. Our goal is to understand RNA function in terms of molecular structure and dynamics using a variety of biophysical and biological tools. We use nuclear magnetic resonance (NMR) spectroscopy to determine structures of biological molecules, and integrate structural understanding into further mechanistic and functional studies. We investigate dynamics using single-molecule approaches. Our goal is a unified picture of structure, dynamics and function. We are currently focused on the mechanism and regulation of translation, and the role of RNA in viral infections. A long-term goal is to target processes involving RNA with novel therapeutic strategies.
Publications
- Uemura S, Iizuka R, Ueno T, Shimizu Y, Taguchi H, Ueda T, Puglisi JD, Funatsu T "Single-molecule imaging of full protein synthesis by immobilized ribosomes." Nucleic Acids Res 2008; More »
- Marshall RA, Aitken CE, Dorywalska M, Puglisi JD "Translation at the Single-Molecule Level." Annu Rev Biochem 2008; 77: 177-203 More »
- Puglisi JD, Doudna JA "Nucleic acids and their protein partners." Curr Opin Struct Biol 2008; 18: 3: 279-281 More »
- McKenna SA, Lindhout DA, Kim I, Liu CW, Gelev VM, Wagner G, Puglisi JD "Molecular framework for the activation of RNA-dependent protein kinase." J Biol Chem 2007; More »
- Uemura S, Dorywalska M, Lee TH, Kim HD, Puglisi JD, Chu S "Peptide bond formation destabilizes Shine-Dalgarno interaction on the ribosome." Nature 2007; 446: 7134: 454-7 More »
82 publications: view full list
