Joseph (Jody) Puglisi
Academic Appointments
- Professor, Structural Biology
- Member, Bio-X
Key Documents
Contact Information
- Academic Offices
Personal Information Email Tel (650) 498-4397Alternate Contact Manolia Margaris Associate Director of Research Administration and Organizational Affairs Email Tel Work (650) 723-9151
Professional Overview
Administrative Appointments
- Member, Advisory Editorial Board, EMBO reports (2011 - present)
- Chair, University Committee on Postdoctoral Affairs, Stanford University (2008 - 2009)
- Chair, Provost's Advisory Board for Postdoctoral Affairs, Stanford University (2005 - 2008)
- Chair, Dept of Structural Biology, Stanford University School of Medicine (2004 - present)
- Director, Int'l School of Biological Magnetic Resonance, EMFCSC, Erice, Italy (2003 - present)
- Senior Editor, Structure (2003 - 2007)
Honors and Awards
- NIH Director's Transformative R01 (T-R01) Program Award, NIH (2011)
- Merit Award, NIH (2011)
- Alfred P. Sloan Research Fellow, Alfred P. Sloan Research Foundation (1997)
- David and Lucille Packard Fellow, David and Lucille Packard Fellowship in Science and Engineering (1994-99)
- Teacher Scholar, Camille and Henry Dreyfus Teacher Scholar Award (1993)
Professional Education
| Ph.D.: | Univ of California, Berkeley, Biophysical Chemistry (1989) |
| B.A.: | The Johns Hopkins University, Chemistry (1984) |
Graduate & Fellowship Program Affiliations
Community and International Work
- Stanford-SJSU IRACDA Program, Stanford and SJSU
- Int'l School of Biological Magnetic Resonance, 10th Course, 22 June-2 July 2010, Erice-Sicily, Italy
- Int'l School of Biological Magnetic Resonance, 9th Course, 22 June-2 July 2009, Erice-Sicily, Italy
- Int'l School of Biological Magnetic Resonance, 8th Course, 19-30 June 2007, Erice-Sicily, Italy
- Int'l School of Biological Magnetic Resonance, 7th Course, 22 June-3 July 2005, Erice-Sicily, Italy
- Int'l School of Biological Magnetic Resonance, 6th Course, 10-22 July 2003, Erice-Sicily, Italy
Internet Links
Industry Relationships
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Scientific Focus
Current Research Interests
The Puglisi group investigates the role of RNA in cellular processes and disease. Our goal is to understand RNA function in terms of molecular structure and dynamics using a variety of biophysical and biological tools. We use nuclear magnetic resonance (NMR) spectroscopy to determine structures of biological molecules, and integrate structural understanding into further mechanistic and functional studies. We investigate dynamics using single-molecule approaches. Our goal is a unified picture of structure, dynamics and function. We are currently focused on the mechanism and regulation of translation, and the role of RNA in viral infections. A long-term goal is to target processes involving RNA with novel therapeutic strategies.
Publications
- Coordinated conformational and compositional dynamics drive ribosome translocation. Nat Struct Mol Biol. 2013
- The impact of aminoglycosides on the dynamics of translation elongation. Cell Rep. 2013; (2): 497-508
- Digging deep into nucleic acid structure and nucleic acid protein recognition. Curr Opin Struct Biol. 2012; (3): 249-50
- Heterogeneous pathways and timing of factor departure during translation initiation. Nature. 2012; (7407): 390-3
- Initiation factor 2, tRNA, and 50S subunits cooperatively stabilize mRNAs on the ribosome during initiation. Proc Natl Acad Sci U S A. 2012; (13): 4881-5
- Nonfluorescent quenchers to correlate single-molecule conformational and compositional dynamics. J Am Chem Soc. 2012; (13): 5734-7
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