Gary Glover

Research/Lab website:   http://rsl.stanford.edu/glover

The work in the Radiological Sciences Laboratory is devoted to the advancement of imaging sciences for applications in diagnostic radiology. We collaborate closely with departmental clinicians and with others in the school of medicine, humanities, and the engineering sciences. The laboratory's activities include development of both CT and MR imaging techniques, with spiral CT Angiography, an example of the former. Work is underway in developing MRI methods for quantitative blood flow imaging, spectroscopic imaging methods for metabolite quantitation, RF pulse design and application, rapid scanning methods, imaging of cardiac and muskuloskeletal dynamic functions, and development of magnetization transfer and other specialized sequences for alternative contrast mechanisms. Applications include breast cancer and renal function imaging.

Presently my research is directed in part towards exploration of rapid scanning methods using spiral and other non-Cartesian k-space trajectories. Using spiral techniques, we have developed MRI pulse sequences and processing methods for mapping cortical brain function by imaging the metabolic response to various stimuli, with applications in the basic neurosciences as well as for clinical applications. These methods develop differential image contrast from hemodynamically driven increases in oxygen content in the vascular bed of activated cortex, using pulse sequences sensitive to the paramagnetic behavior of deoxyhemoglobin or to the blood flow changes.