Theodore Jardetzky

Honors and Awards

• Fellow, American Academy of Microbiology (2008)
• NIH Merit Award, NIAID/NIH (2001-present)
• Research Scholar, Leukemia and Lymphoma Society (2001-2006)
• Investigator Award, Cancer Research Institute (1999-2003)
• Pew Scholar in the Biomedical Sciences, Pew Foundation (1996-2001)

Professional Education

Postdoctoral Advisees

Fengling Liu , Sowmya Sampath , Chao Zou

Graduate & Fellowship Program Affiliations

• Structural Biology

Research Interests

The Jardetzky laboratory is studying the structures and mechanisms of macromolecular complexes important in viral pathogenesis, allergic hypersensitivities and the regulation of cellular growth and differentiation, with an interest in uncovering novel conceptual approaches to intervening in disease processes. Ongoing research projects include studies of paramyxovirus and herpesvirus entry mechanisms, IgE-receptor structure and function and TGF-beta ligand signaling pathways.

Publications

• Class III viral membrane fusion proteins. Backovic M, Jardetzky TS. Curr Opin Struct Biol. 2009; 19 (2): 189-96
• Cleavage and secretion of Epstein-Barr virus glycoprotein 42 promote membrane fusion with B lymphocytes. Sorem J, Jardetzky TS, Longnecker R. J Virol. 2009; 83 (13): 6664-72
• Functional analysis of glycoprotein L (gL) from rhesus lymphocryptovirus in Epstein-Barr virus-mediated cell fusion indicates a direct role of gL in gB-induced membrane fusion. Plate AE, Smajlovi? J, Jardetzky TS, Longnecker R. J Virol. 2009; 83 (15): 7678-89
• Conformational flexibility in immunoglobulin E-Fc 3-4 revealed in multiple crystal forms. Wurzburg BA, Jardetzky TS. J Mol Biol. 2009; 393 (1): 176-90
• Structure of Epstein-Barr virus glycoprotein 42 suggests a mechanism for triggering receptor-activated virus entry. Kirschner AN, Sorem J, Longnecker R, Jardetzky TS. Structure. 2009; 17 (2): 223-33