Stuart Goodman

Clinical Focus

• Adult Reconstruction- Lower Extremity
• Orthopaedic Surgery

Professional Education

Postdoctoral Advisees

Pei-Gen Ren

Research Interests

As an academic orthopaedic surgeon, my interests center on adult reconstructive surgery including total joint replacement, osteotomies and the fixation of fractures. Both clinical and basic science investigations are ongoing.

My specific research interests include the following:

1. the biological aspects of the interface between orthopaedic implants/biomaterials and bone

2. total joint replacement: prosthesis design, biomechanics, biomaterials, mechanisms of failure

3. the effects of mechanical stimulation on mesenchymal tissue differentiation

4. osteoarthritis: etiology, diagnosis, imaging, treatment, outcomes

Clinical Trials

• Evaluation of E-Poly (tm) and Regenerex (tm) Cementless Acetabular Components: Clinical and Radiographic Outcomes Recruiting

Publications

• Ultrahigh molecular weight polyethylene wear debris inhibits osteoprogenitor proliferation and differentiation in vitro. Chiu R, Ma T, Smith RL, Goodman SB. J Biomed Mater Res A. 2009; 89 (1): 242-7
• Efficacy of a p38 mitogen activated protein kinase inhibitor in mitigating an established inflammatory reaction to polyethylene particles in vivo. Ma T, Ren PG, Larsen DM, Suenaga E, Zilber S, Genovese M, Smith RL, Goodman SB. J Biomed Mater Res A. 2009; 89 (1): 117-23
• Biocompatibility of poly(ethylene glycol)/poly(acrylic acid) interpenetrating polymer network hydrogel particles in RAW 264.7 macrophage and MG-63 osteoblast cell lines. Yim ES, Zhao B, Myung D, Kourtis LC, Frank CW, Carter D, Smith RL, Goodman SB. J Biomed Mater Res A. 2009; 91 (3): 894-902
• Increased expression of toll-like receptors in aseptic loose periprosthetic tissues and septic synovial membranes around total hip implants. Tamaki Y, Takakubo Y, Goto K, Hirayama T, Sasaki K, Konttinen YT, Goodman SB, Takagi M. J Rheumatol. 2009; 36 (3): 598-608
• Patellar Management in Revision Total Knee Arthroplasty Is Patellar Resurfacing a Better Option? Patil N, Lee K, Huddleston JI, Harris AH, Goodman SB. J Arthroplasty. 2009