{"result":[{"researchInterest":"Structural and functional studies of transmembrane receptor interactions with their ligands in systems relevant to human health and disease - primarily in immunity, infection, and neurobiology.  We study these problems using protein engineering, structural, biochemical, and combinatorial biology approaches.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4370&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Chris_Garcia","appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Professor,Structural Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Chris","primaryAppointment":"Professor,Molecular & Cellular Physiology","displayName":"Chris Garcia","lastName":"Garcia"},{"researchInterest":"Molecular mechanisms of lymphocyte recognition and differentiation; molecular genetics and expression of T-cell receptor genes.  Dynamics and functionality of specific T cell populations in human cancer.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4282&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Mark_Davis","appointments":[{"appointment":"Professor,Microbiology & Immunology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Mark","primaryAppointment":"Professor,Microbiology & Immunology","displayName":"Mark M. Davis","lastName":"Davis"},{"researchInterest":"We are dedicated to develop multifunctional molecular probes for multimodality imaging and bioconjugates for target-specific drug delivery. The research tools include bioconjugation chemistry, radiochemistry (PET/SPECT), nanotechnology, and stem cell biology.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6470&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Xiaoyuan_Chen","appointments":[{"appointment":"Associate Professor (Research),Radiology - Diagnostic Radiology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Xiaoyuan","primaryAppointment":"Associate Professor (Research),Radiology - Diagnostic Radiology","displayName":"Xiaoyuan (Shawn) Chen","lastName":"Chen"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9743&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Qizhen_Cao","appointments":[{"appointment":"Postdoctoral Research fellow, Radiology"}],"clinicalFocus":[],"firstName":"Qizhen","primaryAppointment":"Postdoctoral Research fellow, Radiology","displayName":"Qizhen Cao","lastName":"Cao"},{"researchInterest":"To develop novel molecular imaging probes and techniques for non-invasively early detection of cancer using multimodality imaging technologies including PET, SPECT, MRI, optical imaging, etc.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8291&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Zhen_Cheng","appointments":[{"appointment":"Assistant Professor (Research),Radiology - Diagnostic Radiology"}],"clinicalFocus":[],"firstName":"Zhen","primaryAppointment":"Assistant Professor (Research),Radiology - Diagnostic Radiology","displayName":"Zhen Cheng","lastName":"Cheng"},{"researchInterest":"Contribution of T cells to immunocompetence and autoimmunity; how the immune system clears infection, avoids autoimmunity and how infection impacts on the development of immune responses.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4121&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Yueh-Hsiu_Chien","appointments":[{"appointment":"Professor,Microbiology & Immunology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Yueh-Hsiu","primaryAppointment":"Professor,Microbiology & Immunology","displayName":"Yueh-hsiu Chien","lastName":"Chien"},{"researchInterest":"My lab of molecular and cellular immunology is interested in research in the general field of T cell activation and autoimmunity.   We use lentiviral mediated transduction of murine dendritic cells with immunoregulatory proteins for site specific and targeted immunotherapy. We have idintified a gene (GRAIL) that seems to control T cell anergy and are defining the regulatory T cell core transcriptome.  Additional studies are on the mechanism of effect of anti-CD3 antibodies in therapy of T1D.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4479&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/C_Fathman","appointments":[{"appointment":"Professor,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Immunology"},{"focus":"Immunology and Rheumatology"}],"firstName":"C","primaryAppointment":"Professor,Medicine - Immunology & Rheumatology","displayName":"C. Garrison Fathman","lastName":"Fathman"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9001&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Lauren_Ely","appointments":[{"appointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology"}],"clinicalFocus":[],"firstName":"Lauren","primaryAppointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology","displayName":"Lauren Ely","lastName":"Ely"},{"researchInterest":"Dr. Nolan's group uses high throughput single cell analysis technology of kinase driven signaling cascades to interrogate autoimmunity, cancer, virology (influenza), bacterial pathogens (Listeria and Salmonella) as well as understanding normal immune system function.  Using advanced flow cytometric techniques and computational biology approaches, we focus on high throughput drug screening, mouse models of disease in patient materials, and understanding disease processes at the single cell level.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4713&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Garry_Nolan","appointments":[{"appointment":"Professor,Microbiology & Immunology - Baxter Laboratory"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Garry","primaryAppointment":"Professor,Microbiology & Immunology - Baxter Laboratory","displayName":"Garry Nolan","lastName":"Nolan"},{"researchInterest":"Our research focuses on the mechanism of action of tetraspanins, an evolutionary conserved, widely expressed multi-gene family. We study a prototype, CD81, a molecule implicated in the pathogenesis of two major human diseases: hepatitis C virus (HCV) and malaria.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4307&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Shoshana_Levy","appointments":[{"appointment":"Professor (Research),Medicine - Oncology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Shoshana","primaryAppointment":"Professor (Research),Medicine - Oncology","displayName":"Shoshana Levy","lastName":"Levy"},{"researchInterest":"The lab is studying the mechanisms controlling B cell responsiveness and the balance between tolerance and autoimmunity.  B cells deficient in CD72 are hyperresponsive to stimulation through the B cell receptor.  We are examining the alterations in B cell signaling in these B cells and the mechanisms by which CD72 deficiency partially abrogates anergic tolerance.  We hope to learn how deficiency in CD72 leads to spontaneous autoimmunity and increased susceptibility to induced autoimmune disease.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4487&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Jane_Parnes","appointments":[{"appointment":"Emeritus Faculty, Acad Council,Medicine - Immunology & Rheumatology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Jane","primaryAppointment":"Emeritus Faculty, Acad Council,Medicine - Immunology & Rheumatology","displayName":"Jane Parnes","lastName":"Parnes"},{"researchInterest":"Our goal is to define targets for cancer therapeutics by identifying alterations in signal transduction proteins. We first identified a naturally occurring  mutant EGF receptor (EGFRvIII) and then delineated its unique signal transduction pathway. This work led to the identification of Gab1 followed by the discovery that JNK is constitutively active in tumors. We intiated using altered proteins as the target for vaccination, where an EGFRvIII based vaccine appears to be highly effective.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7143&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Albert_Wong","appointments":[{"appointment":"Professor,Neurosurgery"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Albert","primaryAppointment":"Professor,Neurosurgery","displayName":"Albert J. Wong, M.D.","lastName":"Wong"},{"researchInterest":"Is it possible to understand the molecular structure and function of proteins and nucleic acids in enough detail to make accurate predictions about structure and function? We are mounting a two-pronged attack on this problem using both molecular dynamics simulation and molecular modeling.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4494&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Michael_Levitt","appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Professor (By courtesy),Computer Science"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Michael","primaryAppointment":"Professor,Structural Biology","displayName":"Michael Levitt","lastName":"Levitt"},{"researchInterest":"Dendritic cells, NK cells and T cells; functional proteins and genes; immunotherapeutic approaches to cancer and autoimmune disease.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4490&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Edgar_Engleman","appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Medicine"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Pathology"},{"focus":"Pathology and Laboratory Medicine"}],"firstName":"Edgar","primaryAppointment":"Professor,Pathology","displayName":"Edgar Engleman","lastName":"Engleman"},{"researchInterest":"Our lab engineers proteins and small-molecule drugs at atomic resolution through a combination of structural calculations and combinatorial library synthesis. Our goal is to elucidate predictive principles by which novel shapes and catalytic properties can be conferred accurately on designed polypeptides.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4433&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Pehr_Harbury","appointments":[{"appointment":"Associate Professor,Biochemistry"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Pehr","primaryAppointment":"Associate Professor,Biochemistry","displayName":"Pehr Harbury","lastName":"Harbury"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8821&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Evan_Newell","appointments":[{"appointment":"Postdoctoral Research fellow, Microbiology & Immunology"}],"clinicalFocus":[],"firstName":"Evan","primaryAppointment":"Postdoctoral Research fellow, Microbiology & Immunology","displayName":"Evan Newell","lastName":"Newell"},{"researchInterest":"Our laboratory studies molecular interactions that underlie the establishment and maintenance of cell and tissue structure.  Our specific areas of interest are the targeted delivery of proteins to intracellular membranes, the architecture and dynamics of intercellular adhesion junctions, and signaling pathways that govern cell fate determination.  We also have a long-standing interest in carbohydrate-based cellular recognition and adhesion.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4259&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/William_Weis","appointments":[{"appointment":"Professor,Structural Biology"},{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"William","primaryAppointment":"Professor,Structural Biology","displayName":"William Weis","lastName":"Weis"},{"researchInterest":"Gene Regulation; Molecular Immunology; Lymphocyte subsets; Fluorescence-Activated Cell\u000bSorter (FACS) development; AIDS; Apoptosis; Redox Regulation; Gene Arrays; and the theraphy of AIDS using the anti-oxidant N'acetylcysteine(NAC).","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4151&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Leonard_Herzenberg","appointments":[{"appointment":"Emeritus (Active) Professor,Genetics"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Leonard","primaryAppointment":"Emeritus (Active) Professor,Genetics","displayName":"Leonard Herzenberg","lastName":"Herzenberg"},{"researchInterest":"My research focus is on tumor angiogenesis.  We are working on the contributions of progenitor cells in the formation of tumor vessels. We are particularly interested in a population of cells that are derived from putative \"hemangioblast\", and their role in vasculogenesis.  We sumrise that these cells have a close association with cancer stem cells, and are essential in promoting tumor expansion.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4421&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Victor_Tse","appointments":[{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Victor","primaryAppointment":"Member,Bio-X","displayName":"Victor Tse, MD PhD","lastName":"Tse"},{"researchInterest":"Understanding genetic basis of cardiovascular function and disease.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4426&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Thomas_Quertermous","appointments":[{"appointment":"Professor,Medicine - Cardiovascular Medicine"}],"clinicalFocus":[],"firstName":"Thomas","primaryAppointment":"Professor,Medicine - Cardiovascular Medicine","displayName":"Thomas Quertermous, MD","lastName":"Quertermous"},{"researchInterest":"I am interested in understanding the pathogenesis of rheumatoid arthritis and other autoimmune diseases. My research is focused on two directions: 1) to use mass spectrometry and c1q assay to identify immune complexes and the autoantigens incorporated in these compelxes; 2) to use protein microarray and statistical tools to discover new antigens or antigen profiles for several autoimmune diseases.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9717&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Xiaoyan_Zhao","appointments":[{"appointment":"Postdoctoral Research fellow, Medicine"}],"clinicalFocus":[],"firstName":"Xiaoyan","primaryAppointment":"Postdoctoral Research fellow, Medicine","displayName":"Xiaoyan Zhao","lastName":"Zhao"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8759&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Amihai_Citri","appointments":[{"appointment":"Postdoctoral Research fellow, Psychiatry & Behavioral Science"}],"clinicalFocus":[],"firstName":"Amihai","primaryAppointment":"Postdoctoral Research fellow, Psychiatry & Behavioral Science","displayName":"Amihai Citri","lastName":"Citri"},{"researchInterest":"B-cell development; Ig rearrangement and repertoire analysis; T cell regulation of antibody\u000bresponses; T cell subsets; glutathione regulation of HIV disease progression; Fluorescence-Activated Cell Sorting (FACS) related software development and gene arrays.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6113&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Leonore_Herzenberg","appointments":[{"appointment":"Professor (Research),Genetics"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Leonore","primaryAppointment":"Professor (Research),Genetics","displayName":"Leonore A. Herzenberg","lastName":"Herzenberg"},{"researchInterest":"Understanding the biology of cancer-T cell interactions.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4564&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Peter_Lee","appointments":[{"appointment":"Associate Professor,Medicine - Hematology"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Hematology"},{"focus":"Leukemia - Hematology"}],"firstName":"Peter","primaryAppointment":"Associate Professor,Medicine - Hematology","displayName":"Peter P. Lee","lastName":"Lee"},{"researchInterest":"My laboratory focuses on merging advances in molecular biology with those in biomedical imaging to advance the new field of molecular imaging. Methods to image gene expression in living subjects have been developed.  Newer approaches to image fundamental cellular events with optical and radiolabeled probes are under active investigation. These imaging approaches are expected to have a fundamental impact in the study of cancer biology,  as well as in molecular therapeutics including gene therapy","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3971&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Sanjiv_Gambhir","appointments":[{"appointment":"Professor,Radiology - Nuclear Medicine"},{"appointment":"Professor (By courtesy),Bioengineering"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[{"focus":"Nuclear Medicine"},{"focus":"Radiology"},{"focus":"PET Scan"}],"firstName":"Sanjiv","primaryAppointment":"Professor,Radiology - Nuclear Medicine","displayName":"Sanjiv Sam Gambhir, MD, PhD","lastName":"Gambhir"}]}