{"result":[{"researchInterest":"We study synaptic communication between brain cells with the goal of understanding neuronal computations and memory mechanisms. Main areas of focus include: presynaptic calcium channels, mechanisms of vesicular fusion and recycling. Modulation of synaptic strength through changes in postsynaptic receptors and dendritic morphology. Signaling that links synaptic activity to nuclear transcription and local protein translation. Techniques include imaging, electrophysiology, molecular biology.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4189&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Richard_Tsien","appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"}],"clinicalFocus":[],"firstName":"Richard","primaryAppointment":"Professor,Molecular & Cellular Physiology","displayName":"Richard Tsien","lastName":"Tsien"},{"researchInterest":"Long-lasting changes in synaptic strength are important for the modification of neural circuits by experience. A major goal of my laboratory is to elucidate the molecular events that trigger various forms of synaptic plasticity and the modifications in synaptic proteins that are responsible for the changes in synaptic efficacy.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4670&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Robert_Malenka","appointments":[{"appointment":"Professor,Psychiatry & Behavioral Science - Psychiatry/Neuroscience/MSLS"}],"clinicalFocus":[],"firstName":"Robert","primaryAppointment":"Professor,Psychiatry & Behavioral Science - Psychiatry/Neuroscience/MSLS","displayName":"Robert Malenka","lastName":"Malenka"},{"researchInterest":"Our group initially identified the hypocretins, two hypothalamic neuropeptides that have a key role in maintaining the states of vigilance. We also discovered cortistatin, a peptide that modulates cortical excitability. My lab uses molecular, pharmacological, anatomical and behavioral methods to identify new roles for these transmitters. We are also interested in the cellular and molecular mechanisms by which neuronal systems integrate homeostatic information and regulate complex behaviors.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7308&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Luis_de Lecea","appointments":[{"appointment":"Associate Professor,Psychiatry & Behavioral Science - Sleep Center"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Luis","primaryAppointment":"Associate Professor,Psychiatry & Behavioral Science - Sleep Center","displayName":"Luis de Lecea","lastName":"de Lecea"},{"researchInterest":"Experiments examine \r\n1)intrinsic properties of neuronal membranes; actions of neurotransmitters that regulate neocortical and thalamic excitability\r\n2) chronic epileptogenesis following cortical injury; changes in intracortical connectivity and receptors; \r\n3) effects of early injury and activity on cortical development/maldevelopment Electrophysiological, anatomical and pharmacological techniques employed.\r\n4. prophylaxis of postraumatic epilepsy\r\n5. Neocortical interneuronal function/modulation","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4531&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/David_Prince","appointments":[{"appointment":"Professor,Neurology & Neurological Sciences"}],"clinicalFocus":[],"firstName":"David","primaryAppointment":"Professor,Neurology & Neurological Sciences","displayName":"David Prince","lastName":"Prince"},{"researchInterest":"We are interested in the neuronal mechanisms that underlie synchronous oscillatory activity in the thalamus, cortex and the massively interconnected thalamocortical system. Such oscillations are related to cognitive processes, normal sleep activities and certain forms of epilepsy. Our approach is an analysis of the discrete components (cells, synapses, microcircuits) that make up thalamic and cortical circuits, and reconstitution of components into in silico computational networks.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4124&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/John_Huguenard","appointments":[{"appointment":"Professor,Neurology & Neurological Sciences"},{"appointment":"Professor (By courtesy),Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"John","primaryAppointment":"Professor,Neurology & Neurological Sciences","displayName":"John Huguenard","lastName":"Huguenard"},{"researchInterest":"Our lab studies the underlying neurobiology of autism and other neuro-developmental disorders.  We are particularly interested in understanding how electrical activity and calcium signals control the development of the brain and how this is altered in children with autism spectrum disorders. We are also developing new tools to study and repair the developing brain.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4040&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Ricardo_Dolmetsch","appointments":[{"appointment":"Assistant Professor,Neurobiology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Ricardo","primaryAppointment":"Assistant Professor,Neurobiology","displayName":"Ricardo Dolmetsch","lastName":"Dolmetsch"},{"researchInterest":"The main interest of my lab is to understand how the properties of neocortical neurons and the circuits they form give rise to cortical activity and function. Our approach includes recordings from multiple cells, calcium imaging, two-photon imaging and viral-based optogenetic methods to activate  cortical neurons as well as cortical afferents.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4343&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Shaul_Hestrin","appointments":[{"appointment":"Associate Professor,Comparative Medicine"}],"clinicalFocus":[],"firstName":"Shaul","primaryAppointment":"Associate Professor,Comparative Medicine","displayName":"Shaul Hestrin","lastName":"Hestrin"},{"researchInterest":"Our laboratory uses electrophysiological techniques to study the mechanisms of synaptic transmission and plasticity in the mammalian hippocampus. One of the main focuses in the lab is in the study of synaptic long-term potentiation (LTP). LTP is the persistent increase in synaptic strength that occurs after a period of heavy activity in a synaptic connection. It is the most widely studied and compelling model for mechanisms underlying memory formation in the mammalian central nervous system.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4321&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Vernon_Madison","appointments":[{"appointment":"Associate Professor,Molecular & Cellular Physiology"}],"clinicalFocus":[],"firstName":"Vernon","primaryAppointment":"Associate Professor,Molecular & Cellular Physiology","displayName":"Daniel V. Madison","lastName":"Madison"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9452&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Ofer_Yizhar","appointments":[{"appointment":"Postdoctoral Research fellow, Bioengineering"}],"clinicalFocus":[],"firstName":"Ofer","primaryAppointment":"Postdoctoral Research fellow, Bioengineering","displayName":"Ofer Yizhar","lastName":"Yizhar"},{"researchInterest":"For most areas of the mammalian brain, neurogenesis concludes at birth but there are exceptions to the rule. In rodents and humans, some areas of the brain continue to make new neurons throughout life. This process is mediated by neural stem cells and our research goals are to understand how stem cell activity is regulated and whether the nascent potential of resident stem cells can be harnessed for brain repair.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5930&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Theo_Palmer","appointments":[{"appointment":"Associate Professor,Neurosurgery"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Theo","primaryAppointment":"Associate Professor,Neurosurgery","displayName":"Theo Palmer","lastName":"Palmer"},{"researchInterest":"We study drug effects on the nervous system. Cellular, synaptic and molecular drug actions are investigated using electrophysiological and pharmacological tools in cortical/hippocampal brain slice preparations. We are also interested in mechanisms of neuronal integration and synchronization, especially related to patterns of EEG activity seen in vivo and in brain slices.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4009&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/M_MacIver","appointments":[{"appointment":"Associate Professor (Research),Anesthesia"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"M","primaryAppointment":"Associate Professor (Research),Anesthesia","displayName":"M Bruce MacIver","lastName":"MacIver"},{"researchInterest":"Our laboratory is studying synapse formation, stability and elimination at a variety of levels, e.g. from molecules to behavior.  A primary focus of the lab is to understanding the role that individual molecules play in the assembly and function of synaptic junctions.  In addition we evaluating a variety of potential treatments for cognitive impairment in Down syndrome in part by assessing the impact specific drugs on cognitive function in mouse models of Down syndrome.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=3890&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Craig_Garner","appointments":[{"appointment":"Professor,Psychiatry & Behavioral Science - Psychiatry/Neuroscience/MSLS"},{"appointment":"Professor (By courtesy),Neurology & Neurological Sciences"}],"clinicalFocus":[],"firstName":"Craig","primaryAppointment":"Professor,Psychiatry & Behavioral Science - Psychiatry/Neuroscience/MSLS","displayName":"Craig C. Garner","lastName":"Garner"},{"researchInterest":"Information transfer at synapses mediates information processing in brain, and is impaired in many brain diseases. Thomas Südhof is interested in how synapses are formed, how presynaptic terminals release neurotransmitters at synapses, and how synapses become dysfunctional in diseases such as autism or Alzheimer's disease. To address these questions, Südhof's laboratory employs approaches ranging from biophysical studies to the electrophysiological and behavioral analyses of mutant mice.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8533&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Thomas_Sudhof","appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Professor (By courtesy),Neurology & Neurological Sciences"},{"appointment":"Professor (By courtesy),Psychiatry & Behavioral Science"}],"clinicalFocus":[],"firstName":"Thomas","primaryAppointment":"Professor,Molecular & Cellular Physiology","displayName":"Thomas Sudhof","lastName":"Sudhof"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9967&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Stephen_Towers","appointments":[],"clinicalFocus":[],"firstName":"Stephen","displayName":"Stephen Towers","lastName":"Towers"},{"researchInterest":"The role of chromatin in stem cell formation and function.  Development of small molecule regulators as experimental probes and therapeutic leads.  Signaling through calcineurin  and NFAT in vertebrate development.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4283&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Gerald_Crabtree","appointments":[{"appointment":"Professor,Pathology"},{"appointment":"Professor,Developmental Biology"},{"appointment":"Member,Bio-X"},{"appointment":"Member,Cancer Center"}],"clinicalFocus":[],"firstName":"Gerald","primaryAppointment":"Professor,Pathology","displayName":"Gerald Crabtree","lastName":"Crabtree"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=8925&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Carson_Goddard","appointments":[{"appointment":"Postdoctoral Research fellow, Neurobiology"}],"clinicalFocus":[],"firstName":"Carson","primaryAppointment":"Postdoctoral Research fellow, Neurobiology","displayName":"Carson Goddard","lastName":"Goddard"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9396&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Zhiping_Pang","appointments":[{"appointment":"Postdoctoral Research fellow, Neurosciences Institute"}],"clinicalFocus":[],"firstName":"Zhiping","primaryAppointment":"Postdoctoral Research fellow, Neurosciences Institute","displayName":"Zhiping Pang","lastName":"Pang"},{"researchInterest":"Mechanisms of epilepsy, especially temporal lobe epilepsy.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4415&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Paul_Buckmaster","appointments":[{"appointment":"Associate Professor,Comparative Medicine"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Paul","primaryAppointment":"Associate Professor,Comparative Medicine","displayName":"Paul Buckmaster, DVM, PhD","lastName":"Buckmaster"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=9980&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Rachel_Groth","appointments":[{"appointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology"}],"clinicalFocus":[],"firstName":"Rachel","primaryAppointment":"Postdoctoral Research fellow, Molecular & Cellular Physiology","displayName":"Rachel Groth","lastName":"Groth"},{"researchInterest":"My research interests encompass several areas of stereotactic and functional neurosurgery, including frameless stereotactic approaches for therapy delivery to deep brain nuclei; deformable patient-specific atlases for targeting brain structures; cortical physiology and its relationship to normal and pathological movement; neural prostheses; and the development of novel neuromodulatory techniques for the treatment of movement disorders, pain, and other neurological diseases.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=6330&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Jaimie_Henderson","appointments":[{"appointment":"Associate Professor - Med Center Line,Neurosurgery"},{"appointment":"Associate Professor - Med Center Line (By courtesy),Neurology & Neurological Sciences"}],"clinicalFocus":[{"focus":"Neurological Surgery"},{"focus":"Neurosurgery"}],"firstName":"Jaimie","primaryAppointment":"Associate Professor - Med Center Line,Neurosurgery","displayName":"Jaimie Henderson","lastName":"Henderson"},{"researchInterest":"We study molecular mechanisms of calcium signaling with a focus on store-operated CRAC channels and their essential roles in T cell development and function.  Currently we aim to define the molecular mechanism for CRAC channel activation and the means by which calcium signal dynamics mediate specific activation of transcription factors and T-cell genes during development.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=4176&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Richard_Lewis","appointments":[{"appointment":"Professor,Molecular & Cellular Physiology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Richard","primaryAppointment":"Professor,Molecular & Cellular Physiology","displayName":"Richard Lewis","lastName":"Lewis"},{"researchInterest":"We are interested in addressing questions in neuronal development and function by a combination of genetic, cell biological, biochemical and chemical approaches. \r\nThe main focus of our lab is centered around two topics: 1) the interface of signaling and gene regulation in neuronal development, with a focus on calcineurin-NFAT signaling; 2) the development of small molecules, which interfere with protein-protein interactions underlying neurodegenerative diseases.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7247&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Isabella_Graef","appointments":[{"appointment":"Assistant Professor,Pathology"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Isabella","primaryAppointment":"Assistant Professor,Pathology","displayName":"Isabella Graef","lastName":"Graef"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=7204&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Kwabena_Boahen","appointments":[{"appointment":"Associate Professor,Bioengineering"},{"appointment":"Associate Professor (By courtesy),Electrical Engineering"},{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Kwabena","primaryAppointment":"Associate Professor,Bioengineering","displayName":"Kwabena Boahen","lastName":"Boahen"},{"researchInterest":"","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=15397&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Jieun_Shin","appointments":[{"appointment":"Postdoctoral Research fellow, Neurosciences Institute"}],"clinicalFocus":[],"firstName":"Jieun","primaryAppointment":"Postdoctoral Research fellow, Neurosciences Institute","displayName":"Jieun Shin","lastName":"Shin"},{"researchInterest":"The McConnell Lab studies the cellular and molecular mechanisms that underlie the development of the mammalian cerebral cortex.  Our work focuses on the earliest events that pattern the developing forebrain, enable neural progenitors to divide asymmetrically to generate young neurons, propel the migration of postmitotic neurons outward into their final positions, and sculpt the fates and phenotypes of the neurons as they differentiate.","imageUrl":"http://med.stanford.edu/profiles/viewImage?facultyId=5928&type=small&showNoImage","href":"http://med.stanford.edu/profiles/bioengineering/researcher/Susan_McConnell","appointments":[{"appointment":"Member,Bio-X"}],"clinicalFocus":[],"firstName":"Susan","primaryAppointment":"Member,Bio-X","displayName":"Susan McConnell","lastName":"McConnell"}]}