Zhen Cheng

Publication Details

• Macrocyclic chelator assembled RGD multimers for tumor targeting.

  Zhang X, Liu H, Miao Z, Kimura R, Fan F, Cheng Z. Bioorg Med Chem Lett. 2011; 21 (11): 3423-6

  Macrocyclic chelators have been extensively used for complexation of metal ions. A widely used chelator, DOTA, has been explored as a molecular platform to assemble multiple bioactive peptides in this paper. The multivalent DOTA-peptide bioconjugates demonstrate promising tumor targeting ability.

  PubMedID: 21524578