Stephen Quake

Publication Details

• Analysis of the size distributions of fetal and maternal cell-free DNA by paired-end sequencing.

  Fan HC, Blumenfeld YJ, Chitkara U, Hudgins L, Quake SR. Clin Chem. 2010; 56 (8): 1279-86

  Noninvasive prenatal diagnosis with cell-free DNA in maternal plasma is challenging because only a small portion of the DNA sample is derived from the fetus. A few previous studies provided size-range estimates of maternal and fetal DNA, but direct measurement of the size distributions is difficult because of the small quantity of cell-free DNA.

  PubMedID: 20558635